HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: MED4 (Q9NPJ6)
Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
Gene: MED4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.668

Property	Details
Experiments	25281560, 25416956, 34079125
Identification Methods	proximity labelling technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 270
+	Hs
		728518 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Hs
		1255137 DLG5_HUMAN (179-436): 1.03e-12: 73.7: 10.31		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00