Protein: SOCS6
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)

Gene: SOCS6
Organism: Homo sapiens
Interactions: 130
UniProt ID: O14544

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006952 - defense response
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

156064

CUL5
Cullin-5

7

20

Small-scale

0.966

High

156043

ELOC
Elongin-C

5

10

Small-scale

0.919

High

155989

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.887

High

156060

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

4

20

High-throughput

0.885

High

156001

KIT
Mast/stem cell growth factor receptor Kit

3

20

Small-scale

0.879

High

156012

TXK
Tyrosine-protein kinase TXK

2

19

High-throughput

0.783

High

156014

CRK
Adapter molecule crk

2

20

High-throughput

0.767

High

156049

CLNK
Cytokine-dependent hematopoietic cell linker

2

20

High-throughput

0.767

High

156044

ELOB
Elongin-B

5

11

Small-scale

0.712

High

155988

ARI2
E3 ubiquitin-protein ligase ARIH2

3

10

High-throughput

0.667

High

156051

FBX11
F-box only protein 11

3

1

High-throughput

0.667

High

156081

SAV1
Protein salvador homolog 1

3

8

High-throughput

0.667

High

156000

ARAF
Serine/threonine-protein kinase A-Raf

1

16

High-throughput

0.665

High

156004

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.665

High

155990

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

156003

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

156042

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

156052

WDTC1
WD and tetratricopeptide repeats protein 1

2

10

High-throughput

0.621

High

155996

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

136229

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

19

Small-scale

0.618

High

156008

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

156096

UBQL1
Ubiquilin-1

2

7

High-throughput

0.611

High

155986

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

2

4

High-throughput

0.611

High

156041

PLEC
Plectin

2

16

High-throughput

0.611

High

155977

IRS4
Insulin receptor substrate 4

2

20

Small-scale

0.601

High

156056

LNX1
E3 ubiquitin-protein ligase LNX

2

19

High-throughput

0.594

High

156094

DP13A
DCC-interacting protein 13-alpha

2

18

High-throughput

0.594

High

156086

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

156011

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.579

High

155980

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.576

High

156077

API5
Apoptosis inhibitor 5

2

0

High-throughput

0.576

High

155982

KDM1A
Lysine-specific histone demethylase 1A

2

2

High-throughput

0.566

High

156061

K0232
Uncharacterized protein KIAA0232

2

1

High-throughput

0.558

High

155991

INSR
Insulin receptor

1

20

Small-scale

0.553

High

156009

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.553

High

156046

AMOT
Angiomotin

1

20

High-throughput

0.541

High

155999

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

156039

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

156069

DCNL1
DCN1-like protein 1

1

3

High-throughput

0.536

High

156089

RBX2
RING-box protein 2

1

13

High-throughput

0.536

High

124136

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.515

High

132410

CDC7
Cell division cycle 7-related protein kinase

1

20

High-throughput

0.515

High

155987

FBX21
F-box only protein 21

1

1

High-throughput

0.515

High

155994

SP1
Transcription factor Sp1

1

8

High-throughput

0.515

High

156007

1433T
14-3-3 protein theta

1

17

High-throughput

0.515

High

156010

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

2

High-throughput

0.515

High

156013

RAGP1
Ran GTPase-activating protein 1

1

5

High-throughput

0.515

High

156015

YAP1
Transcriptional coactivator YAP1

1

11

Small-scale

0.515

High

156018

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.515

High

156020

AFAD
Afadin

1

20

High-throughput

0.515

High

156021

ARP3
Actin-related protein 3

1

5

High-throughput

0.515

High

156022

1433G
14-3-3 protein gamma

1

17

High-throughput

0.515

High

156023

RAB1A
Ras-related protein Rab-1A

1

6

High-throughput

0.515

High

156025

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.515

High

156028

CENPE
Centromere-associated protein E

1

3

High-throughput

0.515

High

156031

DYST
Dystonin

1

20

High-throughput

0.515

High

156033

1433F
14-3-3 protein eta

1

17

High-throughput

0.515

High

156040

TTL12
Tubulin--tyrosine ligase-like protein 12

1

1

High-throughput

0.515

High

156055

WDR48
WD repeat-containing protein 48

1

3

High-throughput

0.515

High

156057

WDR20
WD repeat-containing protein 20

1

12

High-throughput

0.515

High

156062

RBP56
TATA-binding protein-associated factor 2N

1

3

High-throughput

0.515

High

156063

TNPO1
Transportin-1

1

4

High-throughput

0.515

High

156065

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.515

High

156067

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.515

High

156070

GWL
Serine/threonine-protein kinase greatwall

1

20

High-throughput

0.515

High

156071

PDLI5
PDZ and LIM domain protein 5

1

20

High-throughput

0.515

High

156074

CAB45
45 kDa calcium-binding protein

1

2

High-throughput

0.515

High

156076

DCNL5
DCN1-like protein 5

1

3

High-throughput

0.515

High

156078

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

7

High-throughput

0.515

High

156087

RCOR3
REST corepressor 3

1

2

High-throughput

0.515

High

156091

TES
Testin

1

20

High-throughput

0.515

High

156093

CDC23
Cell division cycle protein 23 homolog

1

7

High-throughput

0.515

High

156098

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.515

High

156099

SGT1
Protein SGT1 homolog

1

7

High-throughput

0.515

High

155981

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.515

High

155983

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

20

High-throughput

0.515

High

155992

GELS
Gelsolin

1

5

High-throughput

0.515

High

156016

SYSC
Serine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

156019

HSP72
Heat shock-related 70 kDa protein 2

1

14

High-throughput

0.515

High

155985

DAB1
Disabled homolog 1

1

20

Small-scale

0.501

High

155984

ECI2
Enoyl-CoA delta isomerase 2

1

0

High-throughput

0.493

High

156034

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.493

High

156075

GCP2
Gamma-tubulin complex component 2

1

0

High-throughput

0.493

High

156082

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.493

High

156085

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.493

High

156088

ATX10
Ataxin-10

1

0

High-throughput

0.493

High

156026

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

156032

TF65
Transcription factor p65

1

13

High-throughput

0.481

High

156024

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

0

Small-scale

0.480

High

155993

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

155995

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

155998

DPOLA
DNA polymerase alpha catalytic subunit

1

3

High-throughput

0.479

High

156027

TBB4B
Tubulin beta-4B chain

1

11

Small-scale

0.479

High

156037

ACACA
Acetyl-CoA carboxylase 1

1

6

High-throughput

0.479

High

156047

FA83H
Protein FAM83H

1

4

High-throughput

0.479

High

156048

TBA1A
Tubulin alpha-1A chain

1

14

Small-scale

0.479

High

156059

MADD
MAP kinase-activating death domain protein

1

10

High-throughput

0.479

High

156073

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.479

High

156092

TBD
Tubulin delta chain

1

15

Small-scale

0.479

High

137554

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.470

High

155978

SCAM3
Secretory carrier-associated membrane protein 3

1

3

High-throughput

0.470

High

155979

SCAM1
Secretory carrier-associated membrane protein 1

1

3

High-throughput

0.470

High

155997

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.470

High

156006

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

High-throughput

0.470

High

156017

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.470

High

156030

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

11

High-throughput

0.470

High

156045

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.470

High

156050

KTN1
Kinectin

1

9

High-throughput

0.470

High

156058

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.470

High

156072

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

3

High-throughput

0.470

High

156080

PININ
Pinin

1

5

High-throughput

0.470

High

156083

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

4

High-throughput

0.470

High

156084

DJC11
DnaJ homolog subfamily C member 11

1

6

High-throughput

0.470

High

156090

DIC
Mitochondrial dicarboxylate carrier

1

10

High-throughput

0.470

High

156095

RCOR1
REST corepressor 1

1

2

High-throughput

0.470

High

156100

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.470

High

156101

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

4

High-throughput

0.470

High

156102

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.470

High

156035

Q0VDC6
peptidylprolyl isomerase

1

7

High-throughput

0.470

High

156038

TADBP
TAR DNA-binding protein 43

1

8

High-throughput

0.470

High

156036

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

11

High-throughput

0.439

High

156054

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

4

High-throughput

0.439

High

156068

WDR89
WD repeat-containing protein 89

1

6

High-throughput

0.439

High

156066

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.279

Low

156002

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.269

Low

156005

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.269

Low

156029

NUCB1
Nucleobindin-1

1

0

High-throughput

0.269

Low

156053

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

0

High-throughput

0.269

Low

156079

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.269

Low

156097

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025