Protein: SOCS1
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)

Gene: SOCS1
Organism: Homo sapiens
Interactions: 170
UniProt ID: O15524

Gene Ontology (top 5):
GO:0001817 - regulation of cytokine production
GO:0004860 - protein kinase inhibitor activity
GO:0005126 - cytokine receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193159

JAK2
Tyrosine-protein kinase JAK2

16

20

Small-scale

0.984

High

193280

ELOC
Elongin-C

9

10

Small-scale

0.966

High

193210

JAK1
Tyrosine-protein kinase JAK1

5

20

Small-scale

0.912

High

193237

JAK3
Tyrosine-protein kinase JAK3

4

20

Small-scale

0.851

High

193228

CRK
Adapter molecule crk

3

20

Small-scale

0.840

High

193165

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.834

High

193212

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

20

Small-scale

0.834

High

193229

CRKL
Crk-like protein

3

20

Small-scale

0.834

High

193183

IGF1R
Insulin-like growth factor 1 receptor

3

20

Small-scale

0.829

High

193198

VAV
Proto-oncogene vav

3

20

Small-scale

0.827

High

193177

CSF1R
Macrophage colony-stimulating factor 1 receptor

2

20

Small-scale

0.815

High

193213

TYK2
Non-receptor tyrosine-protein kinase TYK2

3

20

Small-scale

0.814

High

193265

ATM
Serine-protein kinase ATM

2

19

Small-scale

0.806

High

193189

KIT
Mast/stem cell growth factor receptor Kit

2

20

Small-scale

0.800

High

193227

TEC
Tyrosine-protein kinase Tec

2

20

Small-scale

0.783

High

193300

SH3G1
Endophilin-A2

2

20

High-throughput

0.783

High

193169

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

193206

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.776

High

193175

LCK
Tyrosine-protein kinase Lck

2

20

Small-scale

0.768

High

193176

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.768

High

193199

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.768

High

193250

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.768

High

193263

ITK
Tyrosine-protein kinase ITK/TSK

2

20

Small-scale

0.768

High

155053

SOCS2
Suppressor of cytokine signaling 2

2

18

Small-scale

0.754

High

193157

SOCS1
Suppressor of cytokine signaling 1

2

18

Small-scale

0.754

High

193164

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.754

High

193174

INSR
Insulin receptor

2

20

Small-scale

0.754

High

193207

FGFR3
Fibroblast growth factor receptor 3

2

20

Small-scale

0.754

High

193221

FLT3
Receptor-type tyrosine-protein kinase FLT3

2

20

Small-scale

0.754

High

193238

VAV2
Guanine nucleotide exchange factor VAV2

2

20

Small-scale

0.754

High

193262

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.754

High

193267

ATR
Serine/threonine-protein kinase ATR

2

20

Small-scale

0.754

High

193185

MET
Hepatocyte growth factor receptor

2

20

Small-scale

0.738

High

193253

PRKDC
DNA-dependent protein kinase catalytic subunit

2

7

High-throughput

0.737

High

193268

CUL2
Cullin-2

2

20

Small-scale

0.737

High

193181

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.724

High

193190

GHR
Growth hormone receptor

1

20

Small-scale

0.724

High

193261

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.724

High

193170

P53
Cellular tumor antigen p53

4

3

Small-scale

0.702

High

193281

ELOB
Elongin-B

5

10

Small-scale

0.699

High

193298

M3K5
Mitogen-activated protein kinase kinase kinase 5

4

20

Small-scale

0.698

High

193259

TF65
Transcription factor p65

4

10

Small-scale

0.692

High

193182

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.647

High

193194

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

193235

BLK
Tyrosine-protein kinase Blk

1

20

Small-scale

0.647

High

193278

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

193219

IRS1
Insulin receptor substrate 1

3

20

Small-scale

0.640

High

193315

IRS2
Insulin receptor substrate 2

3

20

Small-scale

0.640

High

193196

IL2RB
Interleukin-2 receptor subunit beta

3

20

Small-scale

0.631

High

193160

CYTIP
Cytohesin-interacting protein

2

20

Small-scale

0.620

High

136236

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

19

Small-scale

0.618

High

193201

IL7RA
Interleukin-7 receptor subunit alpha

1

5

Small-scale

0.618

High

193214

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

193257

TIE2
Angiopoietin-1 receptor

1

20

Small-scale

0.618

High

193297

CUL5
Cullin-5

1

20

Small-scale

0.618

High

193317

ASB3
Ankyrin repeat and SOCS box protein 3

1

9

Small-scale

0.618

High

193318

WSB1
WD repeat and SOCS box-containing protein 1

1

3

Small-scale

0.618

High

186669

P73
Tumor protein p73

2

3

Small-scale

0.611

High

193291

COMD1
COMM domain-containing protein 1

2

0

Small-scale

0.607

High

193191

IRF1
Interferon regulatory factor 1

2

8

Small-scale

0.601

High

193240

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

3

Small-scale

0.601

High

193162

DAB1
Disabled homolog 1

2

20

Small-scale

0.584

High

193217

IL3RB
Cytokine receptor common subunit beta

2

20

Small-scale

0.584

High

193224

VHL
von Hippel-Lindau disease tumor suppressor

2

2

Small-scale

0.584

High

193226

ETV6
Transcription factor ETV6

2

3

Small-scale

0.584

High

193270

ELOA1
Elongin-A

2

5

Small-scale

0.584

High

193273

IRF3
Interferon regulatory factor 3

2

8

Small-scale

0.584

High

193301

CLC7A
C-type lectin domain family 7 member A

2

5

Small-scale

0.584

High

193316

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.584

High

193158

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

14

High-throughput

0.571

High

193163

BAG2
BAG family molecular chaperone regulator 2

2

2

High-throughput

0.571

High

193168

TBB4A
Tubulin beta-4A chain

2

11

High-throughput

0.571

High

193171

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

193178

TBB5
Tubulin beta chain

2

11

High-throughput

0.571

High

193180

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.571

High

193184

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.571

High

193192

HSP7C
Heat shock cognate 71 kDa protein

2

14

High-throughput

0.571

High

193193

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

14

High-throughput

0.571

High

193202

HSP76
Heat shock 70 kDa protein 6

2

14

High-throughput

0.571

High

193204

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.571

High

193208

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

2

11

High-throughput

0.571

High

193209

TBG1
Tubulin gamma-1 chain

2

17

Small-scale

0.571

High

193211

PYR1
Multifunctional protein CAD

2

4

High-throughput

0.571

High

193216

DNJA1
DnaJ homolog subfamily A member 1

2

9

High-throughput

0.571

High

193218

CTNB1
Catenin beta-1

2

9

High-throughput

0.571

High

193222

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.571

High

193230

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.571

High

193231

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.571

High

193232

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.571

High

193233

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.571

High

193234

FXR1
RNA-binding protein FXR1

2

4

High-throughput

0.571

High

193242

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

14

High-throughput

0.571

High

193244

ABCE1
ATP-binding cassette sub-family E member 1

2

1

High-throughput

0.571

High

193245

PSME3
Proteasome activator complex subunit 3

2

2

High-throughput

0.571

High

193248

RL39
Large ribosomal subunit protein eL39

2

1

High-throughput

0.571

High

193251

TBB4B
Tubulin beta-4B chain

2

11

High-throughput

0.571

High

193252

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.571

High

193264

TIF1B
Transcription intermediary factor 1-beta

2

14

High-throughput

0.571

High

193272

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

14

High-throughput

0.571

High

193282

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

2

High-throughput

0.571

High

193310

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.571

High

193203

INAR1
Interferon alpha/beta receptor 1

2

20

Small-scale

0.563

High

175456

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

1

7

Small-scale

0.561

High

193294

IRF7
Interferon regulatory factor 7

1

8

Small-scale

0.561

High

193306

CUED2
CUE domain-containing protein 2

1

1

Small-scale

0.561

High

193311

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.553

High

193302

OSBL8
Oxysterol-binding protein-related protein 8

2

0

High-throughput

0.547

High

138901

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

6

High-throughput

0.536

High

193293

MADD
MAP kinase-activating death domain protein

1

6

High-throughput

0.536

High

193295

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

4

High-throughput

0.536

High

193305

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

6

High-throughput

0.536

High

193307

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

10

High-throughput

0.536

High

193312

DICER
Endoribonuclease Dicer

1

6

High-throughput

0.536

High

193223

TPOR
Thrombopoietin receptor

2

9

Small-scale

0.533

High

137562

NDUA4
Cytochrome c oxidase subunit NDUFA4

2

1

High-throughput

0.521

High

193239

TXTP
Tricarboxylate transport protein, mitochondrial

2

12

High-throughput

0.521

High

193254

S25A3
Solute carrier family 25 member 3

2

9

High-throughput

0.521

High

193271

RCN2
Reticulocalbin-2

2

1

High-throughput

0.521

High

193289

DHX29
ATP-dependent RNA helicase DHX29

2

4

High-throughput

0.521

High

193308

ATD3A
ATPase family AAA domain-containing protein 3A

2

10

High-throughput

0.521

High

67446

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.513

High

193266

SMAD4
Mothers against decapentaplegic homolog 4

1

9

High-throughput

0.506

High

193287

FAT4
Protocadherin Fat 4

1

11

High-throughput

0.489

High

193292

FAT3
Protocadherin Fat 3

1

12

High-throughput

0.489

High

193166

PDGFB
Platelet-derived growth factor subunit B

1

1

Small-scale

0.479

High

193167

S100B
Protein S100-B

1

4

Small-scale

0.479

High

193179

PROF1
Profilin-1

1

2

Small-scale

0.479

High

193186

HMGB1
High mobility group protein B1

1

3

Small-scale

0.479

High

193187

CSF1
Macrophage colony-stimulating factor 1

1

2

Small-scale

0.479

High

193195

IRF2
Interferon regulatory factor 2

1

8

Small-scale

0.479

High

193197

INGR1
Interferon gamma receptor 1

1

8

Small-scale

0.479

High

193205

EGR1
Early growth response protein 1

1

3

Small-scale

0.479

High

193215

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

6

Small-scale

0.479

High

193225

ARL1
ADP-ribosylation factor-like protein 1

1

6

Small-scale

0.479

High

193241

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

9

Small-scale

0.479

High

193243

CXCR4
C-X-C chemokine receptor type 4

1

10

Small-scale

0.479

High

193247

RBX1
E3 ubiquitin-protein ligase RBX1

1

9

Small-scale

0.479

High

193249

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

Small-scale

0.479

High

193255

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

15

Small-scale

0.479

High

193256

GHRHR
Growth hormone-releasing hormone receptor

1

4

Small-scale

0.479

High

193258

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

1

Small-scale

0.479

High

193269

TRI14
Tripartite motif-containing protein 14

1

14

Small-scale

0.479

High

193274

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

Small-scale

0.479

High

193275

JOS1
Josephin-1

1

1

Small-scale

0.479

High

193286

ATAT
Alpha-tubulin N-acetyltransferase 1

1

1

Small-scale

0.479

High

193290

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

Small-scale

0.479

High

193296

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

193303

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

16

Small-scale

0.479

High

193304

TRIM5
Tripartite motif-containing protein 5

1

11

Small-scale

0.479

High

193309

PIM2
Serine/threonine-protein kinase pim-2

1

7

Small-scale

0.479

High

193314

TR150
Thyroid hormone receptor-associated protein 3

1

10

Small-scale

0.479

High

193172

IGF1
Insulin-like growth factor 1

1

0

Small-scale

0.458

High

193188

GLI2
Zinc finger protein GLI2

1

0

Small-scale

0.458

High

193246

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

Small-scale

0.458

High

193279

LRC41
Leucine-rich repeat-containing protein 41

1

0

Small-scale

0.458

High

193288

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

193299

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.458

High

193283

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High

193284

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.445

High

193173

ADT2
ADP/ATP translocase 2

1

7

Small-scale

0.437

High

193200

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

Small-scale

0.437

High

193220

BASI
Basigin

1

13

Small-scale

0.437

High

193236

SSRD
Translocon-associated protein subunit delta

1

1

Small-scale

0.437

High

193260

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.437

High

193277

NECT1
Nectin-1

1

9

Small-scale

0.437

High

193285

R39L5
Putative ribosomal protein eL39-like 5

1

1

High-throughput

0.407

High

193276

PDCD1
Programmed cell death protein 1

2

0

Small-scale

0.313

High

193161

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

2

0

High-throughput

0.298

High

193313

RT28
Small ribosomal subunit protein bS1m

2

0

High-throughput

0.298

High


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Last updated: 11Aug2025