Protein: GDS1
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)

Gene: GDS1, RAP1GDS1
Organism: Homo sapiens
Interactions: 109
UniProt ID: P52306

Gene Ontology (top 5):
GO:0003300 - cardiac muscle hypertrophy
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

854090

RAC1
Ras-related C3 botulinum toxin substrate 1

9

6

Small-scale

0.974

High

854084

RHOA
Transforming protein RhoA

9

7

Small-scale

0.972

High

349206

RASH
GTPase HRas

4

8

Small-scale

0.912

High

854088

RAP1A
Ras-related protein Rap-1A

4

10

Small-scale

0.902

High

854154

RAP2C
Ras-related protein Rap-2c

4

12

High-throughput

0.902

High

854081

CDC42
Cell division control protein 42 homolog

4

6

High-throughput

0.888

High

348587

RASN
GTPase NRas

4

8

Small-scale

0.885

High

436217

RHOC
Rho-related GTP-binding protein RhoC

3

7

High-throughput

0.871

High

488066

RRAS
Ras-related protein R-Ras

3

10

High-throughput

0.858

High

854086

RRAS2
Ras-related protein R-Ras2

3

7

High-throughput

0.858

High

854139

RAB6B
Ras-related protein Rab-6B

3

2

High-throughput

0.858

High

349994

RASK
GTPase KRas

3

7

Small-scale

0.858

High

854132

RAB34
Ras-related protein Rab-34

3

3

High-throughput

0.847

High

545277

RAC2
Ras-related C3 botulinum toxin substrate 2

2

6

High-throughput

0.811

High

854079

RAB15
Ras-related protein Rab-15

2

1

High-throughput

0.811

High

854080

RAC3
Ras-related C3 botulinum toxin substrate 3

2

6

High-throughput

0.811

High

854082

RAP1B
Ras-related protein Rap-1b

2

10

High-throughput

0.811

High

854137

RHOF
Rho-related GTP-binding protein RhoF

2

8

High-throughput

0.811

High

303756

DIRA1
GTP-binding protein Di-Ras1

4

14

High-throughput

0.806

High

854121

DIRA2
GTP-binding protein Di-Ras2

4

12

High-throughput

0.806

High

854096

RAB31
Ras-related protein Rab-31

2

1

High-throughput

0.789

High

854083

RAP2B
Ras-related protein Rap-2b

2

12

High-throughput

0.783

High

854115

RSLAA
Ras-like protein family member 10A

3

13

High-throughput

0.770

High

567662

UBF1
Nucleolar transcription factor 1

2

0

High-throughput

0.770

High

854133

RAB1B
Ras-related protein Rab-1B

2

0

High-throughput

0.748

High

506444

RALB
Ras-related protein Ral-B

2

11

High-throughput

0.737

High

854145

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

2

11

High-throughput

0.726

High

486015

RAP2A
Ras-related protein Rap-2a

1

13

High-throughput

0.691

High

854087

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.691

High

854117

APBB2
Amyloid beta precursor protein binding family B member 2

3

0

High-throughput

0.638

High

854127

HSPB9
Heat shock protein beta-9

3

0

High-throughput

0.638

High

854155

T22D4
TSC22 domain family protein 4

3

0

High-throughput

0.638

High

854078

ARL4C
ADP-ribosylation factor-like protein 4C

2

1

High-throughput

0.628

High

845900

RAB28
Ras-related protein Rab-28

1

2

High-throughput

0.618

High

854126

RSLBB
Ras-like protein family member 11B

1

5

High-throughput

0.618

High

854143

RAB20
Ras-related protein Rab-20

1

2

High-throughput

0.618

High

854144

RASLC
Ras-like protein family member 12

1

9

High-throughput

0.618

High

854140

MBIP1
MAP3K12-binding inhibitory protein 1

2

0

High-throughput

0.618

High

854093

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.618

High

854097

SEPT6
Septin-6

3

2

High-throughput

0.609

High

854113

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

2

0

High-throughput

0.602

High

854138

PRD10
PR domain zinc finger protein 10

2

0

High-throughput

0.602

High

854152

BAIP2
BAR/IMD domain-containing adapter protein 2

2

0

High-throughput

0.585

High

338163

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

854106

RN19B
E3 ubiquitin-protein ligase RNF19B

2

0

High-throughput

0.580

High

854131

IFT27
Intraflagellar transport protein 27 homolog

1

1

High-throughput

0.575

High

854102

RABL3
Rab-like protein 3

2

2

High-throughput

0.574

High

318087

DIRA3
GTP-binding protein Di-Ras3

1

12

High-throughput

0.553

High

854120

RHES
GTP-binding protein Rhes

1

12

High-throughput

0.553

High

854099

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

2

High-throughput

0.536

High

489924

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

Small-scale

0.529

High

854122

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

854156

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.518

High

496612

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

625257

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.513

High

744386

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.513

High

790715

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

854089

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

854108

VASH1
Tubulinyl-Tyr carboxypeptidase 1

1

0

High-throughput

0.513

High

854125

CEP89
Centrosomal protein of 89 kDa

1

0

High-throughput

0.513

High

854129

RBM42
RNA-binding protein 42

1

0

High-throughput

0.513

High

854134

GBA3
Cytosolic beta-glucosidase

1

0

High-throughput

0.513

High

854135

RABE2
Rab GTPase-binding effector protein 2

1

0

High-throughput

0.513

High

854147

CRNN
Cornulin

1

0

High-throughput

0.513

High

854151

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

0

High-throughput

0.513

High

854116

KIFA3
Kinesin-associated protein 3

1

0

Small-scale

0.504

High

654188

CALX
Calnexin

1

0

High-throughput

0.493

High

854142

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.493

High

854119

OPTN
Optineurin

1

0

High-throughput

0.493

High

854092

I13R1
Interleukin-13 receptor subunit alpha-1

1

1

High-throughput

0.489

High

854094

ARL16
ADP-ribosylation factor-like protein 16

1

1

High-throughput

0.489

High

854136

IFT22
Intraflagellar transport protein 22 homolog

1

1

High-throughput

0.489

High

174740

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

475507

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

681749

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

580413

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

2

High-throughput

0.479

High

854091

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

2

High-throughput

0.479

High

854110

SEP12
Septin-12

1

2

High-throughput

0.479

High

359785

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

503728

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

546983

EZRI
Ezrin

1

0

High-throughput

0.458

High

716634

CTNA1
Catenin alpha-1

1

0

High-throughput

0.458

High

854095

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

854103

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

854109

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

854114

HDAC7
Histone deacetylase 7

1

0

High-throughput

0.458

High

854118

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

854130

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.458

High

854085

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.438

High

854146

SEP10
Septin-10

1

2

High-throughput

0.437

High

224674

SSX4
Protein SSX4

1

0

High-throughput

0.426

High

854124

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

854148

PKHB1
Pleckstrin homology domain-containing family B member 1

5

0

High-throughput

0.378

High

854101

DNAL1
Dynein axonemal light chain 1

2

0

High-throughput

0.328

High

854104

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

854098

DOC2A
Double C2-like domain-containing protein alpha

1

0

High-throughput

0.282

High

854100

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.279

Low

854105

TMED8
Protein TMED8

1

0

High-throughput

0.279

Low

854111

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.279

Low

854112

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

0

High-throughput

0.279

Low

854149

S18L2
SS18-like protein 2

1

0

High-throughput

0.279

Low

854150

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.265

Low

384531

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

854107

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

854123

CB048
Putative uncharacterized protein C2orf48

1

0

High-throughput

0.249

Low

854128

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

854141

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

854153

SNX24
Sorting nexin-24

1

0

High-throughput

0.249

Low

483365

NARR
Ras-related protein Rab-34, isoform NARR

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024