Protein: CISH
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)

Gene: CISH
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q9NSE2

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0001960 - negative regulation of cytokine-mediated signaling pathway
GO:0005126 - cytokine receptor binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1371879

CUL5
Cullin-5

6

20

Small-scale

0.943

High

619230

EPOR
Erythropoietin receptor

6

20

Small-scale

0.935

High

363915

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.902

High

533858

GHR
Growth hormone receptor

2

20

Small-scale

0.792

High

599227

IL7RA
Interleukin-7 receptor subunit alpha

2

4

Small-scale

0.754

High

838391

STA5A
Signal transducer and activator of transcription 5A

2

20

Small-scale

0.754

High

1403936

CSF3R
Granulocyte colony-stimulating factor receptor

1

20

Small-scale

0.724

High

1420886

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

3

7

High-throughput

0.667

High

1147289

ELOB
Elongin-B

3

12

Small-scale

0.656

High

411076

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

440226

LCK
Tyrosine-protein kinase Lck

1

19

Small-scale

0.618

High

619116

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

15

Small-scale

0.618

High

683523

IKBA
NF-kappa-B inhibitor alpha

1

20

Small-scale

0.618

High

907292

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.618

High

1112999

CUL2
Cullin-2

1

20

Small-scale

0.618

High

1114412

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1147133

ELOC
Elongin-C

1

10

Small-scale

0.618

High

219661

B2L11
Bcl-2-like protein 11

2

1

Small-scale

0.584

High

1407676

MYD88
Myeloid differentiation primary response protein MyD88

1

18

Small-scale

0.552

High

600945

HSP76
Heat shock 70 kDa protein 6

1

15

High-throughput

0.541

High

832497

ETV5
ETS translocation variant 5

1

7

High-throughput

0.541

High

943888

M3KCL
MAP3K7 C-terminal-like protein

1

2

High-throughput

0.541

High

1449361

RBX2
RING-box protein 2

1

12

High-throughput

0.536

High

253386

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.527

High

658782

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.527

High

911955

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.527

High

575832

IL2RB
Interleukin-2 receptor subunit beta

1

20

Small-scale

0.515

High

896901

DYN2
Dynamin-2

1

10

High-throughput

0.515

High

927571

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

1153930

SMAD2
Mothers against decapentaplegic homolog 2

1

7

High-throughput

0.508

High

508698

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

Small-scale

0.479

High

596953

PRLR
Prolactin receptor

1

20

Small-scale

0.479

High

667016

CCNE1
G1/S-specific cyclin-E1

1

2

Small-scale

0.479

High

689968

IL3RA
Interleukin-3 receptor subunit alpha

1

20

Small-scale

0.479

High

992987

RACK1
Small ribosomal subunit protein RACK1

1

7

Small-scale

0.479

High

1195317

TB10B
TBC1 domain family member 10B

1

4

High-throughput

0.479

High

1199714

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

666917

CCNC
Cyclin-C

1

7

Small-scale

0.437

High

991730

DYL1
Dynein light chain 1, cytoplasmic

1

0

Small-scale

0.426

High

163595

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.268

Low

1323261

CARTF
Calcium-responsive transcription factor

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025