Protein: SOCS3
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)

Gene: SOCS3
Organism: Homo sapiens
Interactions: 97
UniProt ID: O14543

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0004860 - protein kinase inhibitor activity
GO:0005126 - cytokine receptor binding
GO:0005829 - cytosol
GO:0009898 - cytoplasmic side of plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

155885

JAK2
Tyrosine-protein kinase JAK2

12

20

Small-scale

0.979

High

155947

ELOC
Elongin-C

6

10

Small-scale

0.950

High

155889

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.920

High

155933

FAK1
Focal adhesion kinase 1

4

20

Small-scale

0.900

High

155917

IL6RB
Interleukin-6 receptor subunit beta

4

20

Small-scale

0.893

High

155896

YES
Tyrosine-protein kinase Yes

3

20

High-throughput

0.871

High

155911

JAK1
Tyrosine-protein kinase JAK1

3

20

Small-scale

0.866

High

155934

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.857

High

155905

EPOR
Erythropoietin receptor

2

20

Small-scale

0.817

High

155921

TXK
Tyrosine-protein kinase TXK

2

20

High-throughput

0.783

High

155925

BLK
Tyrosine-protein kinase Blk

2

20

High-throughput

0.783

High

155888

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.768

High

155922

LEPR
Leptin receptor

2

20

Small-scale

0.768

High

155968

SH22A
SH2 domain-containing protein 2A

2

20

High-throughput

0.767

High

155943

FAK2
Protein-tyrosine kinase 2-beta

2

20

Small-scale

0.757

High

155908

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.757

High

155897

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.740

High

155963

I12R2
Interleukin-12 receptor subunit beta-2

1

20

Small-scale

0.734

High

155948

ELOB
Elongin-B

5

11

Small-scale

0.714

High

155900

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

155960

CUL5
Cullin-5

4

20

Small-scale

0.689

High

155892

INSR
Insulin receptor

2

20

Small-scale

0.675

High

155966

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

3

6

High-throughput

0.667

High

155884

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.665

High

155926

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.665

High

155890

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

155901

GHR
Growth hormone receptor

1

20

Small-scale

0.647

High

155909

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

155946

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

155898

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

155969

RBX2
RING-box protein 2

2

13

Small-scale

0.619

High

155048

SOCS2
Suppressor of cytokine signaling 2

1

19

Small-scale

0.618

High

155893

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.618

High

155894

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

Small-scale

0.618

High

155919

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.618

High

155941

PTK6
Protein-tyrosine kinase 6

1

20

Small-scale

0.618

High

155962

CSF3R
Granulocyte colony-stimulating factor receptor

1

20

Small-scale

0.618

High

155958

RGP1
RAB6A-GEF complex partner protein 2

2

0

High-throughput

0.602

High

155976

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.601

High

116828

I6L996
Focal adhesion kinase-related nonkinase

1

20

High-throughput

0.594

High

155935

TRDN
Triadin

2

7

High-throughput

0.594

High

155914

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.590

High

155931

TF65
Transcription factor p65

2

11

Small-scale

0.584

High

155913

1433T
14-3-3 protein theta

2

19

High-throughput

0.576

High

155942

TFDP1
Transcription factor Dp-1

1

3

Small-scale

0.573

High

155953

MAP1S
Microtubule-associated protein 1S

1

11

Small-scale

0.573

High

155967

CUED2
CUE domain-containing protein 2

1

1

Small-scale

0.573

High

155959

IRF7
Interferon regulatory factor 7

1

7

Small-scale

0.561

High

155971

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.561

High

155910

FGFR3
Fibroblast growth factor receptor 3

1

20

Small-scale

0.553

High

155899

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

155938

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

155940

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

155944

PLSI
Plastin-1

1

16

High-throughput

0.536

High

155939

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.518

High

155883

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

20

High-throughput

0.508

High

155949

MK11
Mitogen-activated protein kinase 11

1

11

High-throughput

0.508

High

155950

MK06
Mitogen-activated protein kinase 6

1

10

High-throughput

0.508

High

155954

CAVN1
Caveolae-associated protein 1

1

0

Small-scale

0.505

High

155891

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

155902

IL2RB
Interleukin-2 receptor subunit beta

1

20

Small-scale

0.501

High

155937

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

11

Small-scale

0.501

High

155923

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

Small-scale

0.481

High

155903

ZEP1
Zinc finger protein 40

1

6

High-throughput

0.481

High

155930

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.481

High

155961

RNF31
E3 ubiquitin-protein ligase RNF31

1

12

High-throughput

0.481

High

155970

TES
Testin

1

20

High-throughput

0.481

High

155886

DAB1
Disabled homolog 1

1

20

Small-scale

0.479

High

155904

PRLR
Prolactin receptor

1

20

Small-scale

0.479

High

155906

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.479

High

155912

IKBA
NF-kappa-B inhibitor alpha

1

20

Small-scale

0.479

High

155915

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.479

High

155918

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.479

High

155920

ETV6
Transcription factor ETV6

1

7

Small-scale

0.479

High

155932

REL
Proto-oncogene c-Rel

1

11

Small-scale

0.479

High

155964

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.479

High

155973

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

20

Small-scale

0.479

High

155975

IRS2
Insulin receptor substrate 2

1

20

Small-scale

0.479

High

155974

SIGL7
Sialic acid-binding Ig-like lectin 7

1

20

Small-scale

0.470

High

155887

SNAI1
Zinc finger protein SNAI1

1

0

Small-scale

0.458

High

143765

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

2

High-throughput

0.439

High

155916

RBMX
RNA-binding motif protein, X chromosome

1

6

High-throughput

0.439

High

155955

TXD11
Thioredoxin domain-containing protein 11

1

8

High-throughput

0.439

High

155972

TFR2
Transferrin receptor protein 2

1

1

High-throughput

0.439

High

155895

CASK
Kappa-casein

1

1

Small-scale

0.437

High

155907

CD33
Myeloid cell surface antigen CD33

1

17

Small-scale

0.437

High

155924

TNF10
Tumor necrosis factor ligand superfamily member 10

1

11

Small-scale

0.437

High

155929

CXCR4
C-X-C chemokine receptor type 4

1

14

Small-scale

0.437

High

155945

NONO
Non-POU domain-containing octamer-binding protein

1

10

Small-scale

0.437

High

155951

TFDP3
Transcription factor Dp family member 3

1

3

Small-scale

0.437

High

155952

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

3

Small-scale

0.437

High

155957

KREM2
Kremen protein 2

1

11

Small-scale

0.437

High

155956

K1958
Uncharacterized protein KIAA1958

3

0

High-throughput

0.352

High

155927

RCAN1
Calcipressin-1

1

0

Small-scale

0.292

High

155928

GFRA1
GDNF family receptor alpha-1

1

0

High-throughput

0.282

High

155965

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

155936

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025