HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.619

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 976
+	Hs
		411962 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		243125 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		337322 ABL1_HUMAN (5-131): 2.58e-34: 127: 25.78		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		442765 HCK_HUMAN (3-125): 2.65e-34: 126: 25.58		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		499244 ABL2_HUMAN (5-131): 3.02e-34: 126: 25.00		KIT_HUMAN (1-976): 0: 807: 100.00
+	Mm
		404012 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		PGFRB_MOUSE (14-974): 0: 597: 29.51
+	Hs
		411953 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		337317 ABL1_HUMAN (5-131): 2.58e-34: 127: 25.78		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		452370 ABL2_HUMAN (5-131): 3.02e-34: 126: 25.00		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		412062 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		337376 ABL1_HUMAN (5-131): 2.58e-34: 127: 25.78		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		738170 ABL2_HUMAN (5-131): 3.02e-34: 126: 25.00		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		412008 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10
+	Dm
		112231 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32
+	Hs
		607907 ABL2_HUMAN (5-131): 3.02e-34: 126: 25.00		FGFR4_HUMAN (4-224): 3.99e-23: 107: 13.21
+	Hs
		507897 ABL2_HUMAN (5-131): 3.02e-34: 126: 25.00		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25
+	Mm
		452181 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53
+	Hs
		411995 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01
+	Hs
		412060 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		VGFR2_HUMAN (3-106): 1.62e-13: 77.5: 14.04
+	Hs
		411943 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10