HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 724
+	Hs
		155993 SOCS6_HUMAN (1-535): 0: 714: 100.00		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		467980 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		461050 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		439909 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		468153 FRK_HUMAN (321-506): 2.07e-54: 193: 18.46		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		440303 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		462949 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		468013 SRC_HUMAN (258-495): 1.88e-51: 185: 15.32		HS90B_HUMAN (1-724): 0: 1083: 100.00
+	Hs
		439904 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		461245 FRK_HUMAN (321-506): 2.07e-54: 193: 18.46		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Dm
		391909 SRC42_DROME (277-502): 2.59e-59: 206: 18.67		HSP83_DROME (10-724): 0: 1053: 78.46
+	Hs
		440299 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		461038 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		461088 SRC_HUMAN (258-495): 1.88e-51: 185: 15.32		HS90A_HUMAN (1-724): 0: 1069: 85.25
+	Hs
		440332 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		ENPL_HUMAN (3-693): 0: 914: 46.44
+	Hs
		473430 HCK_HUMAN (236-495): 1.41e-60: 210: 15.16		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		440105 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		463120 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		440588 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		463119 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		H90B4_HUMAN (25-596): 0: 639: 71.85