Protein: UBR2
E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)

Gene: UBR2
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q8IWV8

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

927763

UBE2B
Ubiquitin-conjugating enzyme E2 B

4

14

Small-scale

0.680

High

155397

NRP1
Neuropilin-1

3

1

High-throughput

0.667

High

558530

GCFC2
Intron Large complex component GCFC2

3

0

High-throughput

0.638

High

580185

AMD
Peptidyl-glycine alpha-amidating monooxygenase

3

0

High-throughput

0.638

High

862264

NUDT6
Nucleoside diphosphate-linked moiety X motif 6

3

0

High-throughput

0.638

High

1152887

MRM1
rRNA methyltransferase 1, mitochondrial

3

1

High-throughput

0.609

High

1016541

HYAL1
Hyaluronidase-1

2

0

High-throughput

0.602

High

749657

BRCA1
Breast cancer type 1 susceptibility protein

2

1

High-throughput

0.584

High

1219652

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.584

High

1081939

PKN1
Serine/threonine-protein kinase N1

2

0

High-throughput

0.580

High

1087042

H2A2C
Histone H2A type 2-C

2

0

Small-scale

0.577

High

534258

YJU2B
Probable splicing factor YJU2B

2

1

High-throughput

0.574

High

589717

ISK2
Serine protease inhibitor Kazal-type 2

2

1

High-throughput

0.574

High

1219659

INSL5
Insulin-like peptide INSL5

2

1

High-throughput

0.574

High

829028

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

14

Small-scale

0.561

High

305224

NXPH2
Neurexophilin-2

2

1

High-throughput

0.558

High

299415

UBXN7
UBX domain-containing protein 7

1

7

High-throughput

0.536

High

347262

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.536

High

535460

GFAP
Glial fibrillary acidic protein

1

4

High-throughput

0.536

High

622642

CRHBP
Corticotropin-releasing factor-binding protein

1

1

High-throughput

0.536

High

678841

HXA7
Homeobox protein Hox-A7

1

2

High-throughput

0.536

High

821785

NEST
Nestin

1

6

High-throughput

0.536

High

886012

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

High-throughput

0.536

High

979324

UBXN1
UBX domain-containing protein 1

1

5

High-throughput

0.536

High

1137090

CROCC
Rootletin

1

1

High-throughput

0.536

High

1167485

CRDL2
Chordin-like protein 2

1

3

High-throughput

0.536

High

1219623

TEX19
Testis-expressed protein 19

1

1

High-throughput

0.536

High

1219656

FAF1
FAS-associated factor 1

1

7

High-throughput

0.536

High

1219629

NTAN1
Protein N-terminal asparagine amidohydrolase

1

1

Small-scale

0.527

High

1219632

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

1

Small-scale

0.527

High

885006

RGS8
Regulator of G-protein signaling 8

1

1

High-throughput

0.515

High

614219

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

983045

SRY
Sex-determining region Y protein

1

0

High-throughput

0.513

High

1125666

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1219622

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

1219624

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.513

High

1219631

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.513

High

1219634

MET2A
tRNA N(3)-methylcytidine methyltransferase METTL2A

1

0

High-throughput

0.513

High

1219639

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

1219648

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.513

High

1219649

PAK5
Serine/threonine-protein kinase PAK 5

1

0

High-throughput

0.513

High

1219657

FOXJ3
Forkhead box protein J3

1

0

High-throughput

0.513

High

358823

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.501

High

908786

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

13

Small-scale

0.501

High

919780

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

11

High-throughput

0.501

High

68236

HECA2
HEPACAM family member 2

1

1

High-throughput

0.489

High

352174

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.489

High

352359

IGF2
Insulin-like growth factor II

1

3

High-throughput

0.489

High

382612

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

2

High-throughput

0.489

High

474742

CFC1
Cryptic protein

1

3

High-throughput

0.489

High

526907

TDGF1
Protein Cripto

1

3

High-throughput

0.489

High

601645

SIAL
Integrin-binding sialoprotein

1

1

High-throughput

0.489

High

610672

IBP4
Insulin-like growth factor-binding protein 4

1

1

High-throughput

0.489

High

870025

LIPR1
Inactive pancreatic lipase-related protein 1

1

1

High-throughput

0.489

High

894878

SPCS3
Signal peptidase complex subunit 3

1

1

High-throughput

0.489

High

1219502

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.489

High

1219625

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

1

High-throughput

0.489

High

1219626

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.489

High

1219628

PMEPA
Protein TMEPAI

1

2

High-throughput

0.489

High

1219630

FAF2
FAS-associated factor 2

1

7

High-throughput

0.489

High

1219633

RCC1L
RCC1-like G exchanging factor-like protein

1

2

High-throughput

0.489

High

1219641

WN10A
Protein Wnt-10a

1

2

High-throughput

0.489

High

1219642

SIL1
Nucleotide exchange factor SIL1

1

1

High-throughput

0.489

High

1219643

IL25
Interleukin-25

1

1

High-throughput

0.489

High

1219653

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.489

High

579217

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

3

Small-scale

0.481

High

918502

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

Small-scale

0.480

High

295004

RECQ4
ATP-dependent DNA helicase Q4

1

1

Small-scale

0.479

High

309975

ATE1
Arginyl-tRNA--protein transferase 1

1

1

Small-scale

0.479

High

351414

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

3

High-throughput

0.479

High

453460

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

476023

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.479

High

803630

BAG6
Large proline-rich protein BAG6

1

1

Small-scale

0.479

High

915814

RHOB
Rho-related GTP-binding protein RhoB

1

1

High-throughput

0.479

High

1062078

UBX2B
UBX domain-containing protein 2B

1

1

High-throughput

0.479

High

1170714

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1219637

PLIN2
Perilipin-2

1

4

Small-scale

0.479

High

1219638

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.479

High

1219640

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

16

Small-scale

0.479

High

1219644

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1219647

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

8

Small-scale

0.479

High

1219655

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

610449

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

868247

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

885272

EPIPL
Epiplakin

1

0

Small-scale

0.458

High

909788

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

1219646

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

517354

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

1219636

CLCC1
Chloride channel CLIC-like protein 1

1

1

Small-scale

0.437

High

1219654

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.407

High

198781

CMIP4
Ciliary microtubule inner protein 4

3

0

High-throughput

0.347

High

1166332

PXDC2
Plexin domain-containing protein 2

3

0

High-throughput

0.347

High

1219627

PKHO2
Pleckstrin homology domain-containing family O member 2

3

0

High-throughput

0.347

High

378452

SODM
Superoxide dismutase [Mn], mitochondrial

3

0

High-throughput

0.342

High

1219645

SMOC1
SPARC-related modular calcium-binding protein 1

2

0

High-throughput

0.328

High

1219658

HS3S2
Heparan sulfate glucosamine 3-O-sulfotransferase 2

2

0

High-throughput

0.328

High

1069122

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.318

High

1072540

EPHA7
Ephrin type-A receptor 7

2

0

Small-scale

0.318

High

1219650

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

2

0

Small-scale

0.318

High

849786

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

351782

SOM2
Growth hormone variant

1

0

High-throughput

0.279

Low

445253

CEL3B
Chymotrypsin-like elastase family member 3B

1

0

High-throughput

0.279

Low

947967

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.279

Low

1029187

NOGG
Noggin

1

0

High-throughput

0.279

Low

1103760

DB110
Beta-defensin 110

1

0

High-throughput

0.279

Low

1219621

CA087
Uncharacterized protein C1orf87

1

0

High-throughput

0.279

Low

1219651

DKK4
Dickkopf-related protein 4

1

0

High-throughput

0.279

Low

63389

MET15
12S rRNA N4-methylcytidine

1

0

Small-scale

0.249

Low

205640

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

266757

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

Small-scale

0.249

Low

873450

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

Small-scale

0.249

Low

1150669

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1219635

SNX18
Sorting nexin-18

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024