Protein: FRK
Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)

Gene: FRK
Organism: Homo sapiens
Interactions: 51
UniProt ID: P42685

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834151

CSK
Tyrosine-protein kinase CSK

3

19

High-throughput

0.871

High

362927

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.858

High

841006

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

5

5

High-throughput

0.720

High

343567

OXSR1
Serine/threonine-protein kinase OSR1

1

20

High-throughput

0.691

High

539966

BCR
Breakpoint cluster region protein

1

19

High-throughput

0.691

High

669112

ARBK1
Beta-adrenergic receptor kinase 1

1

17

High-throughput

0.691

High

733727

GRK4
G protein-coupled receptor kinase 4

1

17

High-throughput

0.691

High

840863

TEC
Tyrosine-protein kinase Tec

1

19

High-throughput

0.691

High

841007

SNTB2
Beta-2-syntrophin

1

11

High-throughput

0.691

High

841011

KS6A1
Ribosomal protein S6 kinase alpha-1

1

20

High-throughput

0.691

High

841014

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

6

High-throughput

0.691

High

841020

PIM3
Serine/threonine-protein kinase pim-3

1

20

High-throughput

0.691

High

841023

TBCK
TBC domain-containing protein kinase-like protein

1

16

High-throughput

0.691

High

841025

AURKB
Aurora kinase B

1

13

High-throughput

0.691

High

841026

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

13

High-throughput

0.691

High

841028

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.691

High

841010

PCBP1
Poly(rC)-binding protein 1

3

12

High-throughput

0.667

High

841021

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

841012

SF3B4
Splicing factor 3B subunit 4

2

9

High-throughput

0.640

High

286761

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.621

High

440428

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.618

High

461245

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468153

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

841004

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

841030

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

12

High-throughput

0.618

High

442628

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.578

High

841002

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

9

Small-scale

0.573

High

63969

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.536

High

209211

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

6

High-throughput

0.536

High

472506

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.536

High

840996

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.536

High

840998

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

841000

RBP2
E3 SUMO-protein ligase RanBP2

1

4

High-throughput

0.536

High

841001

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.536

High

841003

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

High-throughput

0.536

High

841009

RRP5
Protein RRP5 homolog

1

2

High-throughput

0.536

High

841015

PDK4
[Pyruvate dehydrogenase

1

1

High-throughput

0.536

High

841019

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.536

High

841027

DDX23
Probable ATP-dependent RNA helicase DDX23

1

10

High-throughput

0.536

High

841029

SMC4
Structural maintenance of chromosomes protein 4

1

5

High-throughput

0.536

High

841031

TF3C4
General transcription factor 3C polypeptide 4

1

2

High-throughput

0.536

High

840999

COPD
Coatomer subunit delta

1

0

High-throughput

0.513

High

841008

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

841017

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.513

High

840997

YAP1
Transcriptional coactivator YAP1

1

19

Small-scale

0.479

High

841013

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.458

High

841005

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

Small-scale

0.408

High

841016

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.279

Low

841018

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low

841024

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.279

Low

841022

JAGN1
Protein jagunal homolog 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025