Protein: H90B4
Putative heat shock protein HSP 90-beta 4

Gene: H90B4, HSP90AB4P
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q58FF6

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006457 - protein folding
GO:0016887 - ATP hydrolysis activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440588

FYN
Tyrosine-protein kinase Fyn

3

20

High-throughput

0.789

High

731363

STIP1
Stress-induced-phosphoprotein 1

3

20

High-throughput

0.789

High

335325

M3K6
Mitogen-activated protein kinase kinase kinase 6

2

20

High-throughput

0.712

High

463119

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.712

High

549172

CDK4
Cyclin-dependent kinase 4

2

20

High-throughput

0.712

High

651666

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

2

20

High-throughput

0.712

High

783592

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

20

High-throughput

0.712

High

897294

CDK7
Cyclin-dependent kinase 7

2

20

High-throughput

0.712

High

897849

CDK9
Cyclin-dependent kinase 9

2

20

High-throughput

0.712

High

908252

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

2

20

High-throughput

0.712

High

1025270

CDK3
Cyclin-dependent kinase 3

2

18

High-throughput

0.712

High

1025308

CDKL1
Cyclin-dependent kinase-like 1

2

20

High-throughput

0.712

High

1038634

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

2

20

High-throughput

0.712

High

1119674

CDK13
Cyclin-dependent kinase 13

2

20

High-throughput

0.712

High

1154372

STK11
Serine/threonine-protein kinase STK11

2

14

High-throughput

0.712

High

1201978

CDKL4
Cyclin-dependent kinase-like 4

2

20

High-throughput

0.712

High

1201987

MYLK4
Myosin light chain kinase family member 4

2

20

High-throughput

0.712

High

1201991

PDK1L
Serine/threonine-protein kinase PDIK1L

2

20

High-throughput

0.712

High

1201998

STK35
Serine/threonine-protein kinase 35

2

20

High-throughput

0.712

High

1202002

CDK15
Cyclin-dependent kinase 15

2

20

High-throughput

0.712

High

1202007

SRMS
Tyrosine-protein kinase Srms

2

20

High-throughput

0.712

High

1202016

AKT3
RAC-gamma serine/threonine-protein kinase

2

20

High-throughput

0.712

High

290324

KS6A4
Ribosomal protein S6 kinase alpha-4

1

20

High-throughput

0.575

High

461561

HS90A
Heat shock protein HSP 90-alpha

1

18

High-throughput

0.575

High

468451

HS90B
Heat shock protein HSP 90-beta

1

18

High-throughput

0.575

High

484156

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.575

High

840915

TXK
Tyrosine-protein kinase TXK

1

20

High-throughput

0.575

High

846753

GRK6
G protein-coupled receptor kinase 6

1

20

High-throughput

0.575

High

889747

CLK3
Dual specificity protein kinase CLK3

1

20

High-throughput

0.575

High

905588

IRAK1
Interleukin-1 receptor-associated kinase 1

1

6

High-throughput

0.575

High

911931

JAK3
Tyrosine-protein kinase JAK3

1

20

High-throughput

0.575

High

916666

PPP5
Serine/threonine-protein phosphatase 5

1

13

High-throughput

0.575

High

922258

LIMK1
LIM domain kinase 1

1

20

High-throughput

0.575

High

922314

LIMK2
LIM domain kinase 2

1

20

High-throughput

0.575

High

1039123

GUC2D
Retinal guanylyl cyclase 1

1

11

High-throughput

0.575

High

1125467

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.575

High

1158353

CDC37
Hsp90 co-chaperone Cdc37

1

16

High-throughput

0.575

High

1161838

AMHR2
Anti-Muellerian hormone type-2 receptor

1

16

High-throughput

0.575

High

1201980

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.575

High

1201982

ULK3
Serine/threonine-protein kinase ULK3

1

15

High-throughput

0.575

High

1201985

NEK8
Serine/threonine-protein kinase Nek8

1

20

High-throughput

0.575

High

1201990

CDK20
Cyclin-dependent kinase 20

1

19

High-throughput

0.575

High

1201994

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

12

High-throughput

0.575

High

1201997

MK15
Mitogen-activated protein kinase 15

1

20

High-throughput

0.575

High

1202001

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

1202003

PSKH2
Serine/threonine-protein kinase H2

1

20

High-throughput

0.575

High

1202004

TESK2
Dual specificity testis-specific protein kinase 2

1

17

High-throughput

0.575

High

1202005

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

16

High-throughput

0.575

High

1202006

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.575

High

1202010

SGK2
Serine/threonine-protein kinase Sgk2

1

20

High-throughput

0.575

High

908337

TKTL1
Transketolase-like protein 1

2

7

High-throughput

0.552

High

954491

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

6

High-throughput

0.552

High

1202000

CNDP1
Beta-Ala-His dipeptidase

2

7

High-throughput

0.552

High

1202008

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

6

High-throughput

0.552

High

1202009

AGO3
Protein argonaute-3

2

20

High-throughput

0.552

High

1201984

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.528

High

1201992

MREG
Melanoregulin

2

0

High-throughput

0.528

High

1201986

LRC28
Leucine-rich repeat-containing protein 28

2

6

High-throughput

0.504

High

366602

RENI
Renin

1

3

High-throughput

0.479

High

274607

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.445

High

529922

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

572322

CBPM
Carboxypeptidase M

1

3

High-throughput

0.445

High

902246

RAB28
Ras-related protein Rab-28

1

8

High-throughput

0.445

High

902928

DUS3
Dual specificity protein phosphatase 3

1

1

High-throughput

0.445

High

1144012

TEBP
Prostaglandin E synthase 3

1

8

High-throughput

0.445

High

1201981

L2GL2
LLGL scribble cell polarity complex component 2

1

6

High-throughput

0.445

High

1201989

UN45B
Protein unc-45 homolog B

1

20

High-throughput

0.445

High

1201999

DNJB3
DnaJ homolog subfamily B member 3

1

9

High-throughput

0.445

High

1202011

AGO4
Protein argonaute-4

1

20

High-throughput

0.445

High

1202013

AGO2
Protein argonaute-2

1

20

High-throughput

0.445

High

1202014

AGO1
Protein argonaute-1

1

20

High-throughput

0.445

High

1202015

RUVB2
RuvB-like 2

1

9

High-throughput

0.445

High

1202018

NEMO
NF-kappa-B essential modulator

1

9

High-throughput

0.445

High

607694

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.426

High

1202012

RN146
E3 ubiquitin-protein ligase RNF146

1

0

High-throughput

0.426

High

226939

LIAS
Lipoyl synthase, mitochondrial

1

1

High-throughput

0.407

High

1119428

CALI
Calicin

1

20

High-throughput

0.407

High

1201979

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.407

High

1201988

CC117
Coiled-coil domain-containing protein 117

1

3

High-throughput

0.407

High

1201993

TTC9C
Tetratricopeptide repeat protein 9C

1

20

High-throughput

0.407

High

1201996

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

2

High-throughput

0.407

High

1202017

T184B
Transmembrane protein 184B

1

1

High-throughput

0.407

High

207752

MCES
mRNA cap guanine-N(7) methyltransferase

2

0

High-throughput

0.288

High

1201983

PAGE2
P antigen family member 2

1

0

High-throughput

0.249

Low

402313

PA21B
Phospholipase A2

1

0

High-throughput

0.232

Low

1201995

MPLKI
M-phase-specific PLK1-interacting protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025