HitPredict

Interactor 1: DC1I1 (O14576)
Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)
Gene: DYNC1I1

Interactor 2: DYL1 (P63167)
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
Gene: DYNLL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.916

Property	Details
Experiments	20921139, 12475239, 33961781, 11148209, unassigned3799
Identification Methods	affinity chromatography technology, two hybrid, pull down, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Dynein_IC2~Dynein_light
Common GO terms	GO:0000776 - kinetochore GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005868 - cytoplasmic dynein complex and 1 others more... GO:0005874 - microtubule
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 89
+	Hs
		156651 DC1I1_HUMAN (1-645): 2.52e-150: 451: 100.00		DYL2_HUMAN (1-89): 1.69e-45: 142: 93.26
+	Mm
		312373 DC1I1_MOUSE (1-645): 4.62e-145: 436: 95.50		DYL1_MOUSE (1-89): 1.97e-46: 145: 100.00
+	Hs
		991513 DC1I2_HUMAN (1-645): 2.78e-134: 409: 74.88		DYL1_HUMAN (1-89): 1.97e-46: 145: 100.00
+	Hs
		1104242 DC1I2_HUMAN (1-645): 2.78e-134: 409: 74.88		DYL2_HUMAN (1-89): 1.69e-45: 142: 93.26
+	Dm
		1172145 DYIN_DROME (6-635): 1.69e-103: 330: 46.46		DYL1_DROME (1-89): 1.37e-46: 145: 94.38
+	Ce
		233704 O45087_CAEEL (7-636): 9.63e-93: 301: 34.20		DYL1_CAEEL (1-89): 8.29e-46: 143: 92.14
+	Hs
		991653 DC2I1_HUMAN (25-637): 3.76e-80: 276: 15.32		DYL1_HUMAN (1-89): 1.97e-46: 145: 100.00
+	Hs
		1358511 DC2I1_HUMAN (25-637): 3.76e-80: 276: 15.32		DYL2_HUMAN (1-89): 1.69e-45: 142: 93.26
+	Hs
		991668 DC2I2_HUMAN (206-608): 5.91e-80: 264: 20.46		DYL1_HUMAN (1-89): 1.97e-46: 145: 100.00
+	Hs
		1389850 DC2I2_HUMAN (206-608): 5.91e-80: 264: 20.46		DYL2_HUMAN (1-89): 1.69e-45: 142: 93.26
+	Cr
		68516 A8IJZ3_CHLRE (157-608): 1.49e-86: 283: 22.20		A8IRP4_CHLRE (13-88): 3.53e-26: 94.7: 43.37
+	Hs
		845279 LIS1_HUMAN (11-371): 3.92e-19: 92.2: 9.46		DYL1_HUMAN (1-89): 1.97e-46: 145: 100.00
+	Hs
		845343 LIS1_HUMAN (11-371): 3.92e-19: 92.2: 9.46		DYL2_HUMAN (1-89): 1.69e-45: 142: 93.26
+	Hs
		991508 STRN3_HUMAN (364-625): 1.2e-14: 79.6: 13.60		DYL1_HUMAN (1-89): 1.97e-46: 145: 100.00
+	Hs
		1092912 STRN3_HUMAN (364-625): 1.2e-14: 79.6: 13.60		DYL2_HUMAN (1-89): 1.69e-45: 142: 93.26