Protein: DC1I1
Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)

Gene: DC1I1, DYNC1I1
Organism: Homo sapiens
Interactions: 118
UniProt ID: O14576

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0003774 - cytoskeletal motor activity
GO:0003777 - microtubule motor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

156615

DYL1
Dynein light chain 1, cytoplasmic

5

15

Small-scale

0.916

High

156621

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

4

15

High-throughput

0.900

High

156628

DYHC1
Cytoplasmic dynein 1 heavy chain 1

4

15

Small-scale

0.900

High

156651

DYL2
Dynein light chain 2, cytoplasmic

3

15

High-throughput

0.860

High

156610

DYLT3
Dynein light chain Tctex-type 3

3

14

Small-scale

0.849

High

156616

DYLT1
Dynein light chain Tctex-type 1

3

14

Small-scale

0.849

High

156601

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

3

17

Small-scale

0.827

High

156649

DC2I2
Cytoplasmic dynein 2 intermediate chain 2

2

15

High-throughput

0.811

High

156627

DCTN1
Dynactin subunit 1

5

20

Small-scale

0.716

High

156683

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

5

9

Small-scale

0.714

High

156646

BICD2
Protein bicaudal D homolog 2

4

13

Small-scale

0.683

High

156664

NDEL1
Nuclear distribution protein nudE-like 1

4

20

Small-scale

0.676

High

156667

FA83D
Protein FAM83D

3

2

High-throughput

0.674

High

156669

DLRB1
Dynein light chain roadblock-type 1

3

8

High-throughput

0.669

High

156573

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

3

9

High-throughput

0.667

High

156636

H31T
Histone H3.1t

1

13

High-throughput

0.665

High

156606

DYN2
Dynamin-2

1

6

High-throughput

0.656

High

156630

GRB7
Growth factor receptor-bound protein 7

1

3

High-throughput

0.656

High

156672

DISC1
Disrupted in schizophrenia 1 protein

2

2

High-throughput

0.628

High

156570

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

15

High-throughput

0.618

High

156591

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.618

High

156600

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.618

High

156605

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.618

High

156608

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.618

High

156609

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.618

High

156612

ACTZ
Alpha-centractin

1

8

High-throughput

0.618

High

156617

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.618

High

156631

BECN1
Beclin-1

1

1

Small-scale

0.618

High

156640

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

156659

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.618

High

156663

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

17

Small-scale

0.618

High

156673

ARP10
Actin-related protein 10

1

6

High-throughput

0.618

High

156652

BICD1
Protein bicaudal D homolog 1

2

14

Small-scale

0.611

High

156644

CADM4
Cell adhesion molecule 4

1

2

High-throughput

0.587

High

156620

EP300
Histone acetyltransferase p300

2

8

Small-scale

0.584

High

156625

DCTN2
Dynactin subunit 2

2

5

Small-scale

0.584

High

156645

TRI58
E3 ubiquitin-protein ligase TRIM58

1

2

Small-scale

0.578

High

156579

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

10

Small-scale

0.571

High

84332

B6ZDN3
Doublecortin domain containing 1

1

1

Small-scale

0.561

High

156577

GGYF1
GRB10-interacting GYF protein 1

1

10

High-throughput

0.536

High

156614

RL23
Large ribosomal subunit protein uL14

1

2

High-throughput

0.536

High

156626

CUL3
Cullin-3

1

20

High-throughput

0.536

High

156638

SAMD1
Sterile alpha motif domain-containing protein 1

1

8

High-throughput

0.536

High

156639

CO039
Uncharacterized protein C15orf39

1

5

High-throughput

0.536

High

156642

MGAP
MAX gene-associated protein

1

3

High-throughput

0.536

High

156653

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

156582

S100B
Protein S100-B

1

2

High-throughput

0.515

High

156584

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

156602

KSYK
Tyrosine-protein kinase SYK

1

6

High-throughput

0.515

High

156622

SQSTM
Sequestosome-1

1

5

High-throughput

0.515

High

156661

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

3

High-throughput

0.515

High

156665

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.515

High

156674

VPS29
Vacuolar protein sorting-associated protein 29

1

1

High-throughput

0.515

High

156578

KAT7
Histone acetyltransferase KAT7

1

5

High-throughput

0.508

High

156581

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.508

High

156588

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.508

High

156593

RCC1
Regulator of chromosome condensation

1

5

High-throughput

0.508

High

156594

ANXA7
Annexin A7

1

2

High-throughput

0.508

High

156597

CRCM
Colorectal mutant cancer protein

1

5

High-throughput

0.508

High

156599

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

High-throughput

0.508

High

156604

RPGP1
Rap1 GTPase-activating protein 1

1

2

High-throughput

0.508

High

156624

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

High-throughput

0.508

High

156634

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

156641

TAOK1
Serine/threonine-protein kinase TAO1

1

13

High-throughput

0.508

High

156660

F110A
Protein FAM110A

1

1

High-throughput

0.508

High

156580

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.493

High

156575

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

156676

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.486

High

156590

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

4

High-throughput

0.481

High

156662

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.481

High

124685

AIP
AH receptor-interacting protein

1

12

High-throughput

0.479

High

156571

PSA7
Proteasome subunit alpha type-7

1

5

Small-scale

0.479

High

156572

PFD6
Prefoldin subunit 6

1

4

High-throughput

0.479

High

156574

SYNJ1
Synaptojanin-1

1

1

High-throughput

0.479

High

156576

PFD1
Prefoldin subunit 1

1

3

High-throughput

0.479

High

156583

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

156585

IF4E
Eukaryotic translation initiation factor 4E

1

4

High-throughput

0.479

High

156586

HS90A
Heat shock protein HSP 90-alpha

1

10

High-throughput

0.479

High

156587

K1C19
Keratin, type I cytoskeletal 19

1

6

High-throughput

0.479

High

156589

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

6

High-throughput

0.479

High

156592

EGR1
Early growth response protein 1

1

2

High-throughput

0.479

High

156595

BTF3
Transcription factor BTF3

1

5

High-throughput

0.479

High

156596

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

1

Small-scale

0.479

High

156603

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.479

High

156613

PFD3
Prefoldin subunit 3

1

4

High-throughput

0.479

High

156618

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

14

High-throughput

0.479

High

156619

CALD1
Caldesmon

1

20

High-throughput

0.479

High

156623

TBB3
Tubulin beta-3 chain

1

17

Small-scale

0.479

High

156629

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

7

Small-scale

0.479

High

156632

SMAD2
Mothers against decapentaplegic homolog 2

1

3

High-throughput

0.479

High

156633

SEPT7
Septin-7

1

3

High-throughput

0.479

High

156635

DREB
Drebrin

1

6

High-throughput

0.479

High

156637

KLC3
Kinesin light chain 3

1

5

Small-scale

0.479

High

156643

NIN
Ninein

1

20

High-throughput

0.479

High

156647

RAD50
DNA repair protein RAD50

1

16

High-throughput

0.479

High

156650

MCRS1
Microspherule protein 1

1

3

Small-scale

0.479

High

156656

PFD5
Prefoldin subunit 5

1

4

High-throughput

0.479

High

156657

TTC1
Tetratricopeptide repeat protein 1

1

17

High-throughput

0.479

High

156658

DNJC7
DnaJ homolog subfamily C member 7

1

13

High-throughput

0.479

High

156666

TBB1
Tubulin beta-1 chain

1

20

Small-scale

0.479

High

156670

PFD4
Prefoldin subunit 4

1

4

High-throughput

0.479

High

156671

SPHK2
Sphingosine kinase 2

1

3

Small-scale

0.479

High

156675

PFD2
Prefoldin subunit 2

1

3

High-throughput

0.479

High

156677

DCTN4
Dynactin subunit 4

1

2

High-throughput

0.479

High

156678

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

High-throughput

0.479

High

156679

RUVB1
RuvB-like 1

1

10

High-throughput

0.479

High

156680

NUDC
Nuclear migration protein nudC

1

17

High-throughput

0.479

High

156681

SGT1
Protein SGT1 homolog

1

7

High-throughput

0.479

High

156655

RUN3B
RUN domain-containing protein 3B

1

3

High-throughput

0.464

High

156648

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

156598

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.458

High

156607

BPL1
Biotin--protein ligase

1

0

High-throughput

0.458

High

156682

EMIL1
EMILIN-1

1

4

Small-scale

0.457

High

156611

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

104827

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

156654

BT3L4
Transcription factor BTF3 homolog 4

1

5

High-throughput

0.437

High

156668

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025