HitPredict

Interactor 1: IFIT3 (O14879)
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)
Gene: IFIT3

Interactor 2: IFNA8 (P32881)
Interferon alpha-8 (IFN-alpha-8) (Interferon alpha-B) (LeIF B) (Interferon alpha-B2)
Gene: IFNA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0051607 - defense response to virus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 189
+	Hs
		157401 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFNA5_HUMAN (1-189): 9.77e-104: 297: 82.01
+	Hs
		157400 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFN21_HUMAN (1-189): 8.64e-101: 290: 81.48
+	Hs
		157402 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFN14_HUMAN (1-189): 5.33e-100: 288: 80.95
+	Hs
		157399 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFNA7_HUMAN (1-189): 1.65e-99: 287: 77.78
+	Hs
		157398 IFIT3_HUMAN (1-490): 2.07e-117: 355: 100.00		IFNA2_HUMAN (1-189): 1.39e-95: 277: 82.01
+	Hs
		352824 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFNA5_HUMAN (1-189): 9.77e-104: 297: 82.01
+	Hs
		352779 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFN10_HUMAN (1-189): 9.54e-102: 292: 80.42
+	Hs
		352798 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFN21_HUMAN (1-189): 8.64e-101: 290: 81.48
+	Hs
		352836 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFN14_HUMAN (1-189): 5.33e-100: 288: 80.95
+	Hs
		352786 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFNA7_HUMAN (1-189): 1.65e-99: 287: 77.78
+	Hs
		456259 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		IFNA8_HUMAN (1-189): 6.25e-96: 278: 100.00