HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.752

The method score is based on:

Property Details
Experiments 10755617, 21724995, 30420664, 31406107, 11002417, 34839354, 21331078, 11821416, 18949366
Identification Methods affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0006954 - inflammatory response
GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0045121 - membrane raft
and 3 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024