Protein: RFXK
DNA-binding protein RFXANK (Ankyrin repeat family A protein 1) (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein)

Gene: RFXK, RFXANK
Organism: Homo sapiens
Interactions: 152
UniProt ID: O14593

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007265 - Ras protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

158395

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

14

Small-scale

0.847

High

158414

RFX5
DNA-binding protein RFX5

9

3

Small-scale

0.754

High

130865

RFXAP
Regulatory factor X-associated protein

6

1

Small-scale

0.741

High

158446

RFX7
DNA-binding protein RFX7

4

11

Small-scale

0.694

High

158379

ARHGA
Rho guanine nucleotide exchange factor 10

1

13

High-throughput

0.691

High

158384

KS6A4
Ribosomal protein S6 kinase alpha-4

1

3

High-throughput

0.691

High

158386

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.691

High

158392

OXSR1
Serine/threonine-protein kinase OSR1

1

9

High-throughput

0.691

High

158399

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

17

High-throughput

0.691

High

158400

CD11B
Cyclin-dependent kinase 11B

1

4

High-throughput

0.691

High

158412

MK08
Mitogen-activated protein kinase 8

1

8

High-throughput

0.691

High

158429

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

17

High-throughput

0.691

High

158440

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

14

High-throughput

0.691

High

158455

FIGL1
Fidgetin-like protein 1

1

20

High-throughput

0.691

High

158461

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

11

Small-scale

0.691

High

158474

SSH3
Protein phosphatase Slingshot homolog 3

1

9

High-throughput

0.691

High

158477

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

18

High-throughput

0.691

High

158483

NACC2
Nucleus accumbens-associated protein 2

1

12

High-throughput

0.691

High

158486

TONSL
Tonsoku-like protein

1

17

High-throughput

0.691

High

158488

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

18

High-throughput

0.691

High

158410

CASP2
Caspase-2

1

0

Small-scale

0.676

High

158522

FBX7
F-box only protein 7

1

0

High-throughput

0.656

High

158433

BPTF
Nucleosome-remodeling factor subunit BPTF

2

20

High-throughput

0.628

High

158480

N42L2
NEDD4-binding protein 2-like 2

2

3

High-throughput

0.628

High

158405

C2TA
MHC class II transactivator

2

4

Small-scale

0.624

High

158450

ODAD2
Outer dynein arm-docking complex subunit 2

1

12

High-throughput

0.618

High

158469

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

17

High-throughput

0.618

High

158476

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

14

High-throughput

0.618

High

158375

RFXK
DNA-binding protein RFXANK

1

16

Small-scale

0.618

High

158378

AURKA
Aurora kinase A

1

4

High-throughput

0.618

High

158423

H4
Histone H4

1

4

High-throughput

0.618

High

158422

HDAC4
Histone deacetylase 4

2

20

Small-scale

0.613

High

158388

HAUS5
HAUS augmin-like complex subunit 5

2

0

High-throughput

0.602

High

158464

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.578

High

158516

HDAC9
Histone deacetylase 9

1

20

Small-scale

0.561

High

158519

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.561

High

158376

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.536

High

158377

APAF
Apoptotic protease-activating factor 1

1

8

High-throughput

0.536

High

158380

ARHGB
Rho guanine nucleotide exchange factor 11

1

15

Small-scale

0.536

High

158382

PER1
Period circadian protein homolog 1

1

2

High-throughput

0.536

High

158383

SNX3
Sorting nexin-3

1

3

High-throughput

0.536

High

158385

RAD17
Cell cycle checkpoint protein RAD17

1

5

High-throughput

0.536

High

158387

PRP6
Pre-mRNA-processing factor 6

1

3

High-throughput

0.536

High

158390

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

5

High-throughput

0.536

High

158391

SMC2
Structural maintenance of chromosomes protein 2

1

11

High-throughput

0.536

High

158394

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

Small-scale

0.536

High

158398

UBL4A
Ubiquitin-like protein 4A

1

7

Small-scale

0.536

High

158401

DPOD1
DNA polymerase delta catalytic subunit

1

3

High-throughput

0.536

High

158402

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

7

High-throughput

0.536

High

158403

KPYR
Pyruvate kinase PKLR

1

2

High-throughput

0.536

High

158408

RFC3
Replication factor C subunit 3

1

3

High-throughput

0.536

High

158413

BAG6
Large proline-rich protein BAG6

1

7

Small-scale

0.536

High

158417

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

3

High-throughput

0.536

High

158425

GTF2I
General transcription factor II-I

1

2

High-throughput

0.536

High

158426

FOXK1
Forkhead box protein K1

1

7

High-throughput

0.536

High

158427

VIGLN
Vigilin

1

9

High-throughput

0.536

High

158430

FOXK2
Forkhead box protein K2

1

7

High-throughput

0.536

High

158432

DPOE1
DNA polymerase epsilon catalytic subunit A

1

3

High-throughput

0.536

High

158436

TIF1B
Transcription intermediary factor 1-beta

1

11

Small-scale

0.536

High

158437

RIN1
Ras and Rab interactor 1

1

5

High-throughput

0.536

High

158442

CND1
Condensin complex subunit 1

1

3

High-throughput

0.536

High

158444

NAB2
NGFI-A-binding protein 2

1

1

High-throughput

0.536

High

158447

QRIC1
Transcriptional regulator QRICH1

1

8

High-throughput

0.536

High

158449

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

3

High-throughput

0.536

High

158454

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

1

High-throughput

0.536

High

158457

SAMD1
Sterile alpha motif domain-containing protein 1

1

9

High-throughput

0.536

High

158463

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

12

High-throughput

0.536

High

158466

I2BP1
Interferon regulatory factor 2-binding protein 1

1

1

High-throughput

0.536

High

158467

FOXP4
Forkhead box protein P4

1

8

High-throughput

0.536

High

158468

CEP97
Centrosomal protein of 97 kDa

1

4

High-throughput

0.536

High

158470

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.536

High

158475

CTF18
Chromosome transmission fidelity protein 18 homolog

1

11

High-throughput

0.536

High

158481

RAD50
DNA repair protein RAD50

1

9

High-throughput

0.536

High

158482

ARHG1
Rho guanine nucleotide exchange factor 1

1

11

High-throughput

0.536

High

158490

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

1

High-throughput

0.536

High

158491

PHB2
Prohibitin-2

1

2

Small-scale

0.536

High

158493

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.536

High

158494

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

2

High-throughput

0.536

High

158497

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.536

High

158499

NUF2
Kinetochore protein Nuf2

1

7

High-throughput

0.536

High

158503

FA83D
Protein FAM83D

1

1

High-throughput

0.536

High

158504

ESRP2
Epithelial splicing regulatory protein 2

1

7

High-throughput

0.536

High

158505

TF7L2
Transcription factor 7-like 2

1

9

High-throughput

0.536

High

158506

SMC4
Structural maintenance of chromosomes protein 4

1

12

High-throughput

0.536

High

158508

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

High-throughput

0.536

High

158510

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

4

High-throughput

0.536

High

158511

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.536

High

158512

POGK
Pogo transposable element with KRAB domain

1

12

High-throughput

0.536

High

158517

TTF2
Transcription termination factor 2

1

7

High-throughput

0.536

High

158518

TBD2B
TBC1 domain family member 2B

1

5

High-throughput

0.536

High

158514

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.523

High

158420

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

High-throughput

0.515

High

158439

DCTN1
Dynactin subunit 1

1

6

High-throughput

0.515

High

158381

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.513

High

158393

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

158415

PRI1
DNA primase small subunit

1

0

High-throughput

0.513

High

158416

PRI2
DNA primase large subunit

1

0

High-throughput

0.513

High

158418

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.513

High

158419

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.513

High

158421

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.513

High

158456

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.513

High

158459

SETX
Probable helicase senataxin

1

0

High-throughput

0.513

High

158465

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.513

High

158471

BANP
Protein BANP

1

0

High-throughput

0.513

High

158472

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

158473

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.513

High

158479

SYMPK
Symplekin

1

0

High-throughput

0.513

High

158487

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

158496

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.513

High

158498

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.513

High

158509

UCKL1
Uridine-cytidine kinase-like 1

1

0

High-throughput

0.513

High

158513

NCDN
Neurochondrin

1

0

High-throughput

0.513

High

158520

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

158521

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

1

0

High-throughput

0.513

High

158485

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.493

High

158389

MTCL2
Microtubule cross-linking factor 2

1

7

Small-scale

0.489

High

158396

TSP1
Thrombospondin-1

1

14

High-throughput

0.489

High

158431

LMNB2
Lamin-B2

1

6

Small-scale

0.489

High

158443

MARE2
Microtubule-associated protein RP/EB family member 2

1

4

High-throughput

0.489

High

158451

PR14L
Protein PRR14L

1

3

High-throughput

0.489

High

158458

STXB4
Syntaxin-binding protein 4

1

12

High-throughput

0.489

High

158462

PKHH3
Pleckstrin homology domain-containing family H member 3

1

1

High-throughput

0.489

High

158492

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

7

High-throughput

0.489

High

158507

ABCF3
ATP-binding cassette sub-family F member 3

1

3

High-throughput

0.489

High

158515

HOOK1
Protein Hook homolog 1

1

7

High-throughput

0.489

High

158409

HNF4A
Hepatocyte nuclear factor 4-alpha

1

14

High-throughput

0.479

High

158411

HD
Huntingtin

1

4

Small-scale

0.479

High

158424

H31
Histone H3.1

1

12

High-throughput

0.479

High

158441

NFIX
Nuclear factor 1 X-type

1

11

High-throughput

0.479

High

158445

TBR1
T-box brain protein 1

1

1

High-throughput

0.479

High

158452

BLT3A
Bridge-like lipid transfer protein family member 3A

1

1

Small-scale

0.479

High

158478

HDAC2
Histone deacetylase 2

1

13

Small-scale

0.479

High

158500

ARP6
Actin-related protein 6

1

6

High-throughput

0.479

High

158397

CO1A2
Collagen alpha-2(I) chain

1

3

Small-scale

0.470

High

158406

BASI
Basigin

1

5

High-throughput

0.470

High

158407

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.470

High

158438

NFYC
Nuclear transcription factor Y subunit gamma

1

0

High-throughput

0.458

High

49064

BLT3B
Bridge-like lipid transfer protein family member 3B

1

1

Small-scale

0.445

High

158501

CCDC8
Coiled-coil domain-containing protein 8

1

2

Small-scale

0.445

High

158428

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.426

High

158404

SC6A4
Sodium-dependent serotonin transporter

1

1

Small-scale

0.407

High

158434

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

158435

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.279

Low

158453

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

158460

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

158484

KBP
KIF-binding protein

1

0

High-throughput

0.279

Low

158489

CE034
Uncharacterized protein C5orf34

1

0

High-throughput

0.279

Low

158502

KLK15
Kallikrein-15

1

0

High-throughput

0.279

Low

158495

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.269

Low

158523

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low

158448

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025