HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: RN19A (Q9NV58)
E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38)
Gene: RNF19A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11237715
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IBR~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 153 Hs			1 838
+	Hs
		919876 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RN19A_HUMAN (1-838): 0: 1166: 100.00
+	Hs
		159068 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		RN19B_HUMAN (113-637): 0: 650: 69.91
+	Hs
		919757 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RN19B_HUMAN (113-637): 0: 650: 69.91
+	Hs
		159108 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ARI1_HUMAN (62-357): 5.64e-81: 272: 21.77
+	Hs
		159008 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		ARI2_HUMAN (33-365): 3.33e-75: 255: 16.52
+	Hs
		159069 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		R144B_HUMAN (117-394): 1.01e-77: 255: 22.62
+	Hs
		159038 UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00		R144A_HUMAN (128-394): 5.5e-74: 245: 25.00
+	Hs
		849498 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ARI1_HUMAN (62-357): 5.64e-81: 272: 21.77
+	Hs
		312679 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		ARI2_HUMAN (33-365): 3.33e-75: 255: 16.52
+	Hs
		312520 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		ARI2_HUMAN (33-365): 3.33e-75: 255: 16.52
+	Hs
		312553 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		ARI2_HUMAN (33-365): 3.33e-75: 255: 16.52
+	Hs
		842095 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		R144A_HUMAN (128-394): 5.5e-74: 245: 25.00
+	Hs
		842104 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		R144A_HUMAN (128-394): 5.5e-74: 245: 25.00
+	Sc
		549808 UBC4_YEAST (1-148): 7.47e-75: 221: 36.91		HEL1_YEAST (26-353): 5.74e-69: 240: 18.90
+	Hs
		1354303 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RNF14_HUMAN (49-355): 1.72e-68: 236: 18.40
+	Hs
		849474 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF14_HUMAN (49-355): 1.72e-68: 236: 18.40
+	Hs
		919891 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RNF14_HUMAN (49-355): 1.72e-68: 236: 18.40
+	Hs
		1290106 UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93		RNF31_HUMAN (42-362): 8.86e-52: 198: 17.50
+	Hs
		849403 UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93		RNF31_HUMAN (42-362): 8.86e-52: 198: 17.50
+	Hs
		919819 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		RNF31_HUMAN (42-362): 8.86e-52: 198: 17.50