HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	11679592, 21590270
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 926 Hs			1 465
+	Mm
		251109 CSKP_MOUSE (1-926): 0: 973: 99.89		PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66
+	Rn
		1144074 CSKP_RAT (1-926): 0: 945: 97.73		PRKN_RAT (1-465): 2.14e-136: 402: 85.16
+	Hs
		159239 CSKP_HUMAN (1-926): 0: 973: 100.00		CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58
+	Hs
		159293 CSKP_HUMAN (1-926): 0: 973: 100.00		ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67
+	Hs
		159140 CSKP_HUMAN (1-926): 0: 973: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		227429 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228930 PALS2_HUMAN (347-926): 1.42e-149: 454: 37.65		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227141 DLG4_HUMAN (402-922): 1.14e-145: 451: 22.56		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227863 MARK2_HUMAN (4-680): 5.16e-140: 438: 18.64		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226582 MARK3_HUMAN (4-669): 7.23e-139: 434: 19.62		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Dm
		677697 DLG1_DROME (445-923): 5.3e-145: 456: 21.50		PRKN_DROME (1-463): 3.5e-106: 325: 42.19
+	Hs
		227381 KCC2D_HUMAN (8-312): 3.56e-88: 291: 47.71		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		229082 KCC2A_HUMAN (8-312): 6.34e-85: 282: 46.08		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		1168519 PALS1_HUMAN (361-925): 9.64e-148: 454: 27.84		RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18
+	At
		1091642 CDPKB_ARATH (4-460): 1.58e-136: 419: 24.21		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475723 KCC2D_HUMAN (8-312): 3.56e-88: 291: 47.71		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47