HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	35384245, 19362549
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 821
+	Hs
		159864 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR1_HUMAN (1-820): 0: 772: 71.17
+	Hs
		159889 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR3_HUMAN (10-821): 0: 731: 65.69
+	Hs
		159888 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR4_HUMAN (22-810): 0: 684: 55.86
+	Hs
		159898 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30
+	Hs
		159900 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58
+	Hs
		159938 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA4_HUMAN (18-794): 4.37e-165: 506: 18.60
+	Hs
		159937 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA5_HUMAN (18-766): 3.48e-163: 502: 17.53
+	Hs
		160216 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA6_HUMAN (9-788): 5.01e-162: 499: 17.99
+	Hs
		160014 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31
+	Hs
		160004 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA7_HUMAN (64-791): 2.59e-157: 486: 19.23
+	Hs
		159897 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA2_HUMAN (18-798): 4.64e-157: 485: 19.21
+	Hs
		160015 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK2_HUMAN (123-765): 4.81e-153: 469: 23.43
+	Rn
		1144355 HGS_RAT (1-777): 3.19e-100: 328: 93.44		NTRK2_RAT (123-765): 5.12e-154: 472: 23.90
+	Mm
		546322 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		NTRK2_MOUSE (123-765): 2.35e-154: 473: 23.90
+	Hs
		159848 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		RET_HUMAN (228-816): 2.74e-144: 455: 34.26
+	Hs
		159837 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04
+	Hs
		276988 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		RET_HUMAN (228-816): 2.74e-144: 455: 34.26
+	Hs
		241132 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04
+	Hs
		276985 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04
+	Hs
		159845 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		CSF1R_HUMAN (467-753): 1.87e-78: 275: 43.11