HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PREX1 (Q8TCU6)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)
Gene: PREX1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1659
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (35-1654): 0: 1931: 57.19
+	Hs
		900947 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG4_HUMAN (6-462): 7.15e-88: 304: 28.97
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (6-487): 6.24e-83: 294: 20.04
+	Hs
		50573 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG3_HUMAN (1-465): 3.76e-79: 289: 25.37
+	Hs
		50580 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHG3_HUMAN (1-465): 3.76e-79: 289: 25.37
+	Hs
		901037 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV3_HUMAN (9-475): 2.21e-77: 277: 21.38
+	Hs
		900428 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TIAM1_HUMAN (2-416): 3.12e-73: 273: 25.84
+	Hs
		900636 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG8_HUMAN (7-474): 3.07e-78: 273: 18.56
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (1-457): 2.35e-74: 269: 21.67
+	Hs
		900916 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ECT2_HUMAN (17-442): 9.98e-74: 268: 18.99
+	Hs
		166479 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2L_HUMAN (6-432): 1.11e-71: 265: 21.25
+	Hs
		166482 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MCF2L_HUMAN (6-432): 1.11e-71: 265: 21.25
+	Hs
		900913 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG2_HUMAN (9-394): 2.43e-70: 263: 26.26
+	Rn
		88818 RAC1_RAT (1-193): 8.86e-80: 237: 57.22		D3ZWV8_RAT (37-416): 2.48e-70: 263: 26.96
+	Mm
		925795 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		TIAM1_MOUSE (37-416): 3.58e-70: 263: 26.96
+	Hs
		900648 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGP_HUMAN (13-413): 2.95e-69: 246: 21.46
+	Sp
		778936 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		SCD1_SCHPO (53-389): 5.53e-26: 118: 26.45
+	Sp
		778939 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		SCD1_SCHPO (53-389): 5.53e-26: 118: 26.45
+	Hs
		900813 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGH_HUMAN (21-314): 1.3e-23: 111: 29.97
+	Ce
		975575 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		VAV_CAEEL (54-319): 6.28e-23: 108: 27.52