HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22706924
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031623 - receptor internalization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 635
+	Hs
		159937 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42
+	Hs
		159864 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		159898 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA3_HUMAN (174-632): 2.58e-114: 366: 24.89
+	Hs
		160015 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		NTRK2_HUMAN (158-631): 7.36e-116: 366: 24.27
+	Rn
		1144355 HGS_RAT (1-777): 3.19e-100: 328: 93.44		NTRK2_RAT (164-631): 5.57e-116: 367: 23.96
+	Hs
		159897 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Mm
		546322 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		NTRK2_MOUSE (164-631): 6.74e-116: 366: 23.96
+	Hs
		159938 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA4_HUMAN (329-626): 1.47e-105: 343: 34.54
+	Hs
		277036 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA5_HUMAN (171-632): 5.04e-115: 370: 25.42
+	Hs
		276996 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		277011 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA3_HUMAN (174-632): 2.58e-114: 366: 24.89
+	Hs
		277074 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		NTRK2_HUMAN (158-631): 7.36e-116: 366: 24.27
+	Hs
		277010 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		159830 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		508231 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		665436 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		EPHA3_HUMAN (174-632): 2.58e-114: 366: 24.89
+	Hs
		277037 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA4_HUMAN (329-626): 1.47e-105: 343: 34.54
+	Hs
		276982 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		339057 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		277005 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81