HitPredict

Interactor 1: RPC1 (O14802)
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Gene: POLR3A

Interactor 2: RPB4 (O15514)
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)
Gene: POLR2D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RNA_pol_Rpb1_1~RNA_pol_Rpb4, RNA_pol_Rpb1_5~RNA_pol_Rpb4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 142
+	Bt
		107931 RPB1_BOVIN (2-1382): 0: 1534: 32.10		RPB4_BOVIN (1-142): 5.46e-59: 181: 99.30
+	Hs
		192787 RPB1_HUMAN (2-1382): 0: 1534: 32.10		RPB4_HUMAN (1-142): 4.02e-59: 181: 100.00
+	Sp
		268285 RPB1_SCHPO (1-1372): 0: 1475: 32.95		RPB4_SCHPO (14-141): 4.51e-46: 147: 41.09
+	Sc
		401879 RPB1_YEAST (1-1381): 0: 1438: 31.80		RPB4_YEAST (42-140): 3.41e-27: 102: 35.58
+	At
		1231324 NRPD1_ARATH (13-1383): 0: 866: 20.15		NRPD4_ARATH (4-141): 4.53e-45: 147: 20.42
+	At
		1204050 NRPE1_ARATH (3-1377): 0: 818: 19.12		NRPD4_ARATH (4-141): 4.53e-45: 147: 20.42
+	Hs
		192771 RPA1_HUMAN (1147-1366): 4.79e-51: 200: 23.87		RPB4_HUMAN (1-142): 4.02e-59: 181: 100.00
+	Sc
		534210 RPA1_YEAST (7-146): 6.58e-36: 151: 22.86		RPB4_YEAST (42-140): 3.41e-27: 102: 35.58