Protein: RPB4
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)

Gene: RPB4, POLR2D
Organism: Homo sapiens
Interactions: 135
UniProt ID: O15514

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

192806

RPB7
DNA-directed RNA polymerase II subunit RPB7

9

4

Small-scale

0.974

High

192787

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

8

Small-scale

0.967

High

192789

RPB2
DNA-directed RNA polymerase II subunit RPB2

5

3

Small-scale

0.934

High

192763

MCE1
mRNA-capping enzyme

4

1

High-throughput

0.895

High

192842

MED8
Mediator of RNA polymerase II transcription subunit 8

2

0

High-throughput

0.770

High

192866

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

High-throughput

0.770

High

192798

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

6

2

Small-scale

0.736

High

192835

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

6

1

High-throughput

0.735

High

192808

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

6

1

Small-scale

0.734

High

192784

RPB3
DNA-directed RNA polymerase II subunit RPB3

5

4

Small-scale

0.723

High

192785

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

1

Small-scale

0.723

High

192863

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

5

6

High-throughput

0.716

High

192831

SPT6H
Transcription elongation factor SPT6

1

1

High-throughput

0.691

High

192872

PIHD1
PIH1 domain-containing protein 1

5

0

High-throughput

0.684

High

192792

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

4

High-throughput

0.675

High

192804

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

1

High-throughput

0.675

High

192846

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

3

5

High-throughput

0.675

High

48877

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

High-throughput

0.674

High

192766

RECQ5
ATP-dependent DNA helicase Q5

4

0

Small-scale

0.674

High

192797

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

1

Small-scale

0.670

High

192814

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

High-throughput

0.667

High

131589

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

2

Small-scale

0.656

High

192770

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.646

High

192850

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

High-throughput

0.646

High

192881

GPN3
GPN-loop GTPase 3

4

1

High-throughput

0.630

High

130310

SPT5H
Transcription elongation factor SPT5

2

1

High-throughput

0.628

High

192761

MED14
Mediator of RNA polymerase II transcription subunit 14

2

4

High-throughput

0.628

High

192788

RBTN2
Rhombotin-2

2

1

High-throughput

0.628

High

192800

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

1

High-throughput

0.628

High

192854

MED28
Mediator of RNA polymerase II transcription subunit 28

3

0

High-throughput

0.628

High

164982

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

8

High-throughput

0.618

High

192771

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

8

High-throughput

0.618

High

192858

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

3

High-throughput

0.618

High

192869

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.618

High

192886

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

4

High-throughput

0.618

High

192815

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

3

0

High-throughput

0.616

High

192861

GPN1
GPN-loop GTPase 1

2

1

High-throughput

0.611

High

192765

MED6
Mediator of RNA polymerase II transcription subunit 6

2

0

High-throughput

0.602

High

192818

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.602

High

192826

MED27
Mediator of RNA polymerase II transcription subunit 27

2

0

High-throughput

0.602

High

192841

CPNE2
Copine-2

2

0

High-throughput

0.602

High

192862

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.602

High

192871

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

High-throughput

0.602

High

192873

ASB6
Ankyrin repeat and SOCS box protein 6

2

0

High-throughput

0.602

High

192874

MED29
Mediator of RNA polymerase II transcription subunit 29

2

0

High-throughput

0.602

High

192778

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

0

High-throughput

0.585

High

192807

H4
Histone H4

2

0

High-throughput

0.585

High

192834

ARHGJ
Rho guanine nucleotide exchange factor 19

2

0

High-throughput

0.547

High

192812

EMX1
Homeobox protein EMX1

1

1

High-throughput

0.541

High

192768

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.536

High

192791

T2FA
General transcription factor IIF subunit 1

1

1

High-throughput

0.536

High

192810

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.536

High

192813

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

192822

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.536

High

192823

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

3

High-throughput

0.536

High

192851

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

2

High-throughput

0.536

High

192853

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.536

High

192856

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.536

High

192887

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

High-throughput

0.536

High

192790

HXC9
Homeobox protein Hox-C9

1

0

High-throughput

0.518

High

192837

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

192888

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

192775

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

192776

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

192779

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

192786

TBP
TATA-box-binding protein

1

0

High-throughput

0.513

High

192795

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

192799

LIMK1
LIM domain kinase 1

1

0

High-throughput

0.513

High

192809

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.513

High

192817

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.513

High

192821

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

192828

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

192833

RBM45
RNA-binding protein 45

1

0

High-throughput

0.513

High

192840

CUL5
Cullin-5

1

0

High-throughput

0.513

High

192843

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.513

High

192848

EPAS1
Endothelial PAS domain-containing protein 1

1

0

High-throughput

0.513

High

192857

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

192860

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.513

High

192864

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

192870

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

High-throughput

0.513

High

192875

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

192885

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

180178

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

High-throughput

0.479

High

192772

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

192773

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

192801

H2B1D
Histone H2B type 1-D

1

3

High-throughput

0.479

High

192802

ELOF1
Transcription elongation factor 1 homolog

1

1

Small-scale

0.479

High

192811

ERCC6
DNA excision repair protein ERCC-6

1

1

Small-scale

0.479

High

192849

H2B1L
Histone H2B type 1-L

1

3

High-throughput

0.479

High

192876

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

4

High-throughput

0.479

High

192884

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

4

High-throughput

0.479

High

190744

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

192760

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

192762

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

192764

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

192767

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.458

High

192774

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

192780

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.458

High

192781

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

192782

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

192783

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

192793

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

192794

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

192796

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

192819

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

192824

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

192827

INT5
Integrator complex subunit 5

1

0

High-throughput

0.458

High

192836

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

192838

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

192852

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

192855

RPAP3
RNA polymerase II-associated protein 3

1

0

High-throughput

0.458

High

192867

INT10
Integrator complex subunit 10

1

0

Small-scale

0.458

High

192868

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.458

High

192878

UXT
Protein UXT

1

0

High-throughput

0.458

High

192879

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

192880

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.458

High

192882

INT6
Integrator complex subunit 6

1

0

High-throughput

0.458

High

192883

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

0

High-throughput

0.458

High

192832

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

High-throughput

0.438

High

192877

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.437

High

192777

MYZAP
Myocardial zonula adherens protein

1

0

High-throughput

0.426

High

192803

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

192847

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

192859

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

192825

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

192830

SYDE1
Rho GTPase-activating protein SYDE1

2

0

High-throughput

0.328

High

192816

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.282

High

192769

CCN6
Cellular communication network factor 6

1

0

High-throughput

0.279

Low

192839

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

192829

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

192845

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

192865

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.249

Low

192805

LYSC
Lysozyme C

1

0

High-throughput

0.232

Low

192820

PROL4
Proline-rich protein 4

1

0

High-throughput

0.232

Low

192844

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025