HitPredict

Interactor 1: AREL1 (O15033)
Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)
Gene: AREL1

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	25752577, 25723849, 28943312
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 823 Hs			1 685
+	Hs
		475984 HUWE1_HUMAN (383-822): 3.51e-166: 536: 29.32		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476205 ITCH_HUMAN (392-821): 1.77e-168: 512: 31.36		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475470 NEDD4_HUMAN (390-821): 3.87e-162: 507: 33.26		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		125113 WWP2_HUMAN (388-821): 1.99e-164: 501: 31.01		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476229 NED4L_HUMAN (430-821): 2.06e-163: 501: 32.83		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476350 WWP1_HUMAN (405-821): 8.31e-162: 496: 29.44		UBC_HUMAN (1-685): 0: 846: 100.00
+	Sp
		143368 PTR1_SCHPO (392-822): 7.41e-153: 497: 29.75		UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80
+	At
		1091758 UPL1_ARATH (405-822): 8.04e-159: 515: 33.03		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1091762 UPL2_ARATH (275-822): 2.23e-157: 511: 28.79		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		924239 HUWE1_MOUSE (383-822): 7.62e-166: 535: 29.32		RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00
+	Mm
		476858 HUWE1_MOUSE (383-822): 7.62e-166: 535: 29.32		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		125347 WWP2_HUMAN (388-821): 1.99e-164: 501: 31.01		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Hs
		475080 HUWE1_HUMAN (383-822): 3.51e-166: 536: 29.32		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		924156 WWP1_HUMAN (405-821): 8.31e-162: 496: 29.44		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Rn
		1140970 Q5YB86_RAT (392-821): 2.42e-168: 510: 31.36		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		397834 NEDD4_HUMAN (390-821): 3.87e-162: 507: 33.26		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		475140 ITCH_HUMAN (392-821): 1.77e-168: 512: 31.36		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		474953 NEDD4_HUMAN (390-821): 3.87e-162: 507: 33.26		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		125112 WWP2_HUMAN (388-821): 1.99e-164: 501: 31.01		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		475196 SMUF2_HUMAN (435-822): 2.75e-161: 489: 30.63		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70