HitPredict

Interactor 1: SYNJ2 (O15056)
Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)
Gene: SYNJ2

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	0.60	0.595

Property	Details
Experiments	12421765, 22558309
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1496 Hs			1 1697
+	Hs
		166049 SYNJ2_HUMAN (1-1496): 0: 1398: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Rn
		1126747 SYNJ1_RAT (1-1492): 0: 1215: 41.06		Q5JC29_RAT (7-410): 1.28e-31: 136: 18.55
+	Mm
		1159873 SHIP2_MOUSE (454-1318): 7.57e-143: 472: 19.96		ITSN1_MOUSE (2-1693): 0: 861: 56.37
+	Hs
		176448 SHIP2_HUMAN (454-1318): 6.35e-139: 462: 19.82		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Ce
		105278 SYNJ_CAEEL (5-1135): 0: 940: 34.85		VAV_CAEEL (1141-1621): 1.34e-70: 260: 16.44
+	Dm
		112574 Q5U0V7_DROME (1-1174): 0: 1056: 40.62		M9ND00_DROME (1-447): 2.52e-32: 139: 14.35
+	Ce
		105276 SYNJ_CAEEL (5-1135): 0: 940: 34.85		O76572_CAEEL (1057-1576): 6.73e-67: 242: 16.48
+	Ce
		105281 SYNJ_CAEEL (5-1135): 0: 940: 34.85		Q9U2T9_CAEEL (666-1214): 4.67e-17: 89.9: 13.17
+	Hs
		203228 SYNJ1_HUMAN (1141-1494): 1.09e-11: 72.2: 14.92		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		203230 SYNJ1_HUMAN (1141-1494): 1.09e-11: 72.2: 14.92		SH319_HUMAN (1035-1211): 6.54e-11: 69.3: 28.26