Protein: ECHP
Peroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]

Gene: ECHP, EHHADH
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q08426

Gene Ontology (top 5):
GO:0003857 - (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO:0004165 - delta(3)-delta(2)-enoyl-CoA isomerase activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0005777 - peroxisome
GO:0005782 - peroxisomal matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1063992

TRI41
E3 ubiquitin-protein ligase TRIM41

5

4

High-throughput

0.702

High

186540

TRI18
E3 ubiquitin-protein ligase Midline-1

3

16

High-throughput

0.654

High

1063987

KCTD6
BTB/POZ domain-containing protein KCTD6

3

4

High-throughput

0.640

High

571944

TRI27
Zinc finger protein RFP

2

4

High-throughput

0.611

High

606106

DESM
Desmin

2

2

High-throughput

0.611

High

709116

TPP2
Tripeptidyl-peptidase 2

2

3

High-throughput

0.596

High

952776

ACTB
Actin, cytoplasmic 1

2

4

High-throughput

0.596

High

993145

ACTG
Actin, cytoplasmic 2

2

4

High-throughput

0.596

High

1063946

TNIP1
TNFAIP3-interacting protein 1

2

5

High-throughput

0.596

High

228028

SSNA1
Microtubule nucleation factor SSNA1

2

0

High-throughput

0.571

High

771876

CBS
Cystathionine beta-synthase

2

0

High-throughput

0.571

High

1064000

ZBTB9
Zinc finger and BTB domain-containing protein 9

2

8

High-throughput

0.558

High

1063955

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

4

High-throughput

0.544

High

1063961

C102B
Coiled-coil domain-containing protein 102B

2

1

High-throughput

0.544

High

1063966

KCTD9
BTB/POZ domain-containing protein KCTD9

2

4

High-throughput

0.544

High

220767

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

High-throughput

0.515

High

286960

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

3

High-throughput

0.515

High

623302

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

High-throughput

0.515

High

635070

CAN3
Calpain-3

1

1

High-throughput

0.515

High

950238

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.515

High

1008696

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.515

High

1048834

REL
Proto-oncogene c-Rel

1

4

High-throughput

0.515

High

1063939

VAC14
Protein VAC14 homolog

1

2

High-throughput

0.515

High

1063940

TRAF2
TNF receptor-associated factor 2

1

8

High-throughput

0.515

High

1063941

TRAF1
TNF receptor-associated factor 1

1

5

High-throughput

0.515

High

1063951

Q1KLZ0
HCG15971, isoform CRA_a

1

4

High-throughput

0.515

High

1063953

GRAP1
GRIP1-associated protein 1

1

1

High-throughput

0.515

High

1063986

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.515

High

1064012

LZTS2
Leucine zipper putative tumor suppressor 2

1

6

High-throughput

0.515

High

1064019

KR411
Keratin-associated protein 4-11

1

1

High-throughput

0.515

High

1064023

TRIM5
Tripartite motif-containing protein 5

1

4

High-throughput

0.515

High

1064042

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.515

High

1064043

ARMX3
Armadillo repeat-containing X-linked protein 3

1

1

High-throughput

0.515

High

1064052

CEP83
Centrosomal protein of 83 kDa

1

2

High-throughput

0.515

High

130947

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.493

High

162553

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.493

High

353684

DRC4
Dynein regulatory complex subunit 4

1

0

High-throughput

0.493

High

1046348

UBXN1
UBX domain-containing protein 1

1

0

High-throughput

0.493

High

1063950

SMN
Survival motor neuron protein

1

0

High-throughput

0.493

High

1063974

HID1
Protein HID1

1

0

High-throughput

0.493

High

1064016

HTAI2
Protein HTATIP2

1

0

High-throughput

0.493

High

1064032

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.493

High

1064033

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.493

High

1064034

PICK1
PRKCA-binding protein

1

0

High-throughput

0.493

High

1064045

IKZF3
Zinc finger protein Aiolos

1

0

High-throughput

0.493

High

958419

ACTZ
Alpha-centractin

1

8

High-throughput

0.479

High

138562

CLD5
Claudin-5

1

2

High-throughput

0.470

High

226320

SNG1
Synaptogyrin-1

1

1

High-throughput

0.470

High

226482

SNG3
Synaptogyrin-3

1

1

High-throughput

0.470

High

275010

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.470

High

770847

OPRM
Mu-type opioid receptor

1

1

High-throughput

0.470

High

783247

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.470

High

787543

TNR3
Tumor necrosis factor receptor superfamily member 3

1

2

High-throughput

0.470

High

883411

CY561
Transmembrane ascorbate-dependent reductase CYB561

1

1

High-throughput

0.470

High

889559

CLK2
Dual specificity protein kinase CLK2

1

2

High-throughput

0.470

High

942407

CLD18
Claudin-18

1

2

High-throughput

0.470

High

1004485

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.470

High

1063956

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.470

High

1063960

ARM12
Armadillo repeat-containing protein 12

1

1

High-throughput

0.470

High

1063963

SCAR5
Scavenger receptor class A member 5

1

1

High-throughput

0.470

High

1063978

CCD13
Coiled-coil domain-containing protein 13

1

3

High-throughput

0.470

High

1063979

AN36B
Ankyrin repeat domain-containing protein 36B

1

2

High-throughput

0.470

High

1063980

RDHE2
Epidermal retinol dehydrogenase 2

1

6

High-throughput

0.470

High

1063984

BOLL
Protein boule-like

1

1

High-throughput

0.470

High

1063985

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

1

1

High-throughput

0.470

High

1063988

PNMA1
Paraneoplastic antigen Ma1

1

2

High-throughput

0.470

High

1063996

FGF14
Fibroblast growth factor 14

1

2

High-throughput

0.470

High

1063997

TRI63
E3 ubiquitin-protein ligase TRIM63

1

14

High-throughput

0.470

High

1063998

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.470

High

1063999

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

7

High-throughput

0.470

High

1064001

ZBT10
Zinc finger and BTB domain-containing protein 10

1

5

High-throughput

0.470

High

1064006

GMCL1
Germ cell-less protein-like 1

1

2

High-throughput

0.470

High

1064008

PNMA5
Paraneoplastic antigen-like protein 5

1

2

High-throughput

0.470

High

1064010

NACC1
Nucleus accumbens-associated protein 1

1

8

High-throughput

0.470

High

1064020

TRI54
Tripartite motif-containing protein 54

1

14

High-throughput

0.470

High

1064030

HM20A
High mobility group protein 20A

1

3

High-throughput

0.470

High

1064048

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.470

High

1064049

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.470

High

1064044

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

14

High-throughput

0.457

High

668568

APC
Adenomatous polyposis coli protein

1

2

High-throughput

0.445

High

762308

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

7

High-throughput

0.445

High

875637

PRC2A
Protein PRRC2A

1

1

High-throughput

0.445

High

1063944

MAP7
Ensconsin

1

4

High-throughput

0.445

High

1063945

CUL7
Cullin-7

1

6

High-throughput

0.445

High

1063957

HABP4
Intracellular hyaluronan-binding protein 4

1

2

High-throughput

0.445

High

1063972

FBX11
F-box only protein 11

1

1

High-throughput

0.445

High

1063976

CUL9
Cullin-9

1

6

High-throughput

0.445

High

1063977

KLHL7
Kelch-like protein 7

1

1

High-throughput

0.445

High

1064021

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.445

High

1064024

LSG1
Large subunit GTPase 1 homolog

1

1

High-throughput

0.445

High

1064037

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.445

High

1064041

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.445

High

1064046

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

1

High-throughput

0.445

High

1064050

WBP11
WW domain-binding protein 11

1

1

High-throughput

0.445

High

1064011

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

884322

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.426

High

1063964

CENPU
Centromere protein U

1

0

High-throughput

0.426

High

1063967

CENPQ
Centromere protein Q

1

0

High-throughput

0.426

High

1063968

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.426

High

1063973

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.426

High

1064013

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

1

0

High-throughput

0.426

High

1064018

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.426

High

1064026

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.426

High

1064051

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.426

High

47262

A0A6Q8KRG2
Golgin subfamily A member 2

1

1

High-throughput

0.417

High

136880

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

4

High-throughput

0.407

High

283680

GPC4
Glypican-4

1

7

High-throughput

0.407

High

284666

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

2

High-throughput

0.407

High

371863

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.407

High

616745

SDC1
Syndecan-1

1

6

High-throughput

0.407

High

636071

CD11B
Cyclin-dependent kinase 11B

1

4

High-throughput

0.407

High

726654

SDC4
Syndecan-4

1

5

High-throughput

0.407

High

760431

SDC2
Syndecan-2

1

6

High-throughput

0.407

High

1022535

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

2

High-throughput

0.407

High

1063942

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.407

High

1063943

ELOA1
Elongin-A

1

1

High-throughput

0.407

High

1063959

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

2

High-throughput

0.407

High

1063995

GSLG1
Golgi apparatus protein 1

1

1

High-throughput

0.407

High

1064002

RMXL1
RNA binding motif protein, X-linked-like-1

1

2

High-throughput

0.407

High

1064014

DIDO1
Death-inducer obliterator 1

1

1

High-throughput

0.407

High

1064025

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.407

High

1064036

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.407

High

1064038

DDX18
ATP-dependent RNA helicase DDX18

1

1

High-throughput

0.407

High

1064053

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

2

High-throughput

0.407

High

1064054

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

7

High-throughput

0.407

High

1063969

NECA2
N-terminal EF-hand calcium-binding protein 2

2

0

High-throughput

0.311

High

1063975

FUND1
FUN14 domain-containing protein 1

2

0

High-throughput

0.311

High

154969

BHE40
Class E basic helix-loop-helix protein 40

1

0

High-throughput

0.268

Low

161356

PTGES
Prostaglandin E synthase

1

0

High-throughput

0.268

Low

329629

LERL1
Leptin receptor overlapping transcript-like 1

1

0

High-throughput

0.268

Low

932683

EMP1
Epithelial membrane protein 1

1

0

High-throughput

0.268

Low

951938

SYCY2
Syncytin-2

1

0

High-throughput

0.268

Low

1009641

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.268

Low

1063947

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.268

Low

1063948

UT2
Urea transporter 2

1

0

High-throughput

0.268

Low

1063949

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.268

Low

1063954

NACHO
Novel acetylcholine receptor chaperone

1

0

High-throughput

0.268

Low

1063962

LYPD5
Ly6/PLAUR domain-containing protein 5

1

0

High-throughput

0.268

Low

1063965

SMIM5
Small integral membrane protein 5

1

0

High-throughput

0.268

Low

1063970

CDR2L
Cerebellar degeneration-related protein 2-like

1

0

High-throughput

0.268

Low

1063971

TMM17
Transmembrane protein 17

1

0

High-throughput

0.268

Low

1063981

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.268

Low

1063982

JAGN1
Protein jagunal homolog 1

1

0

High-throughput

0.268

Low

1063983

MB213
Protein mab-21-like 3

1

0

High-throughput

0.268

Low

1063990

PAQR8
Membrane progestin receptor beta

1

0

High-throughput

0.268

Low

1063991

SFT2A
Vesicle transport protein SFT2A

1

0

High-throughput

0.268

Low

1063994

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.268

Low

1064004

RUSF1
RUS family member 1

1

0

High-throughput

0.268

Low

1064005

REEP6
Receptor expression-enhancing protein 6

1

0

High-throughput

0.268

Low

1064009

DERL3
Derlin-3

1

0

High-throughput

0.268

Low

1064015

TM121
Transmembrane protein 121

1

0

High-throughput

0.268

Low

1064017

CA050
Uncharacterized protein C1orf50

1

0

High-throughput

0.268

Low

1064022

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

0

High-throughput

0.268

Low

1064028

ZBT26
Zinc finger and BTB domain-containing protein 26

1

0

High-throughput

0.268

Low

1064029

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.268

Low

1064031

S39A2
Zinc transporter ZIP2

1

0

High-throughput

0.268

Low

1064035

RPRM
Protein reprimo

1

0

High-throughput

0.268

Low

1064039

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.268

Low

1064040

ORML1
ORM1-like protein 1

1

0

High-throughput

0.268

Low

1064047

COF2
Cofilin-2

1

0

High-throughput

0.268

Low

635452

CO5A1

1

0

High-throughput

0.232

Low

1063952

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.232

Low

1063958

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.232

Low

1063989

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.232

Low

1063993

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

1064003

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.232

Low

1064007

KIRR1
Kin of IRRE-like protein 1

1

0

High-throughput

0.232

Low

1064027

ESF1
ESF1 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025