Protein: ECHD1
Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD)

Gene: ECHD1, ECHDC1
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q9NTX5

Gene Ontology (top 5):
GO:0004492 - methyl/ethyl malonyl-CoA decarboxylase activity
GO:0005829 - cytosol
GO:0006635 - fatty acid beta-oxidation
GO:0016831 - carboxy-lyase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1334981

SERB1
SERPINE1 mRNA-binding protein 1

2

3

High-throughput

0.601

High

1128958

I13R2
Interleukin-13 receptor subunit alpha-2

2

7

High-throughput

0.574

High

1436698

GORS2
Golgi reassembly-stacking protein 2

2

1

High-throughput

0.553

High

1310456

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.536

High

1411620

FSP1
Ferroptosis suppressor protein 1

1

4

High-throughput

0.536

High

1372319

H2B1H
Histone H2B type 1-H

1

4

High-throughput

0.515

High

423289

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

164702

TNF11
Tumor necrosis factor ligand superfamily member 11

1

1

High-throughput

0.489

High

166056

FFAR1
Free fatty acid receptor 1

1

7

High-throughput

0.489

High

182795

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.489

High

771244

APJ
Apelin receptor

1

4

High-throughput

0.489

High

1250713

NPSR1
Neuropeptide S receptor

1

4

High-throughput

0.489

High

1291907

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

6

High-throughput

0.489

High

1363236

AQP3
Aquaporin-3

1

1

High-throughput

0.489

High

1437863

MAGF1
Melanoma-associated antigen F1

1

3

High-throughput

0.489

High

1449653

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

487802

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

831505

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

861310

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.479

High

897403

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.479

High

942915

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

1140925

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1380194

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

1397473

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1399104

SCLT1
Sodium channel and clathrin linker 1

1

3

High-throughput

0.479

High

1449648

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1449650

MOK
MAPK/MAK/MRK overlapping kinase

1

2

High-throughput

0.470

High

1363865

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1449649

GGA1
ADP-ribosylation factor-binding protein GGA1

1

0

High-throughput

0.458

High

1209710

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1226738

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

4

High-throughput

0.445

High

1227543

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

1391797

AURKB
Aurora kinase B

1

1

High-throughput

0.445

High

1449651

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

4

High-throughput

0.445

High

1449652

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

4

High-throughput

0.445

High

106717

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

703980

DUS1
Dual specificity protein phosphatase 1

1

1

High-throughput

0.437

High

879512

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

1100439

TIF1B
Transcription intermediary factor 1-beta

1

10

High-throughput

0.437

High

1194629

DUS28
Dual specificity phosphatase 28

1

2

High-throughput

0.437

High

1418021

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

2

High-throughput

0.437

High

1429365

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

1434009

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

404927

PRIO
Major prion protein

1

0

High-throughput

0.426

High

638532

FPR1
fMet-Leu-Phe receptor

1

5

High-throughput

0.407

High

652257

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

2

High-throughput

0.407

High

653601

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.407

High

754111

CD80
T-lymphocyte activation antigen CD80

1

3

High-throughput

0.407

High

848573

MAGA8
Melanoma-associated antigen 8

1

3

High-throughput

0.407

High

1101677

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

6

High-throughput

0.407

High

1366262

LPAR1
Lysophosphatidic acid receptor 1

1

5

High-throughput

0.407

High

733088

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

946596

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.279

Low

1249776

TM108
Transmembrane protein 108

1

0

High-throughput

0.279

Low

1325930

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1330609

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

1349127

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1447214

GPR84
G-protein coupled receptor 84

1

0

High-throughput

0.279

Low

1410466

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

1210119

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

1218865

GP107
Protein GPR107

1

0

High-throughput

0.232

Low

1251892

CCNI2
Cyclin-I2

1

0

High-throughput

0.232

Low

1350608

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025