HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: TOPRS (Q9NS56)
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
Gene: TOPORS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 153 Hs			1 1045
+	Hs
		1449085 UB2D4_HUMAN (2-149): 4.15e-76: 224: 38.93		TOPRS_HUMAN (1-1045): 0: 765: 100.00
+	Hs
		906794 UB2D1_HUMAN (2-149): 1.12e-75: 223: 38.93		TOPRS_HUMAN (1-1045): 0: 765: 100.00
+	Hs
		982333 UB2D2_HUMAN (2-149): 3.48e-75: 222: 37.58		TOPRS_HUMAN (1-1045): 0: 765: 100.00
+	Hs
		957212 UB2D3_HUMAN (2-149): 5.81e-74: 219: 36.24		TOPRS_HUMAN (1-1045): 0: 765: 100.00
+	Hs
		1381207 UB2E3_HUMAN (3-148): 2.11e-68: 207: 31.97		TOPRS_HUMAN (1-1045): 0: 765: 100.00
+	Hs
		909395 UB2E1_HUMAN (3-148): 6.24e-67: 203: 34.01		TOPRS_HUMAN (1-1045): 0: 765: 100.00
+	Hs
		957850 UBE2N_HUMAN (4-151): 5.07e-65: 196: 29.73		TOPRS_HUMAN (1-1045): 0: 765: 100.00
+	Hs
		67236 UB2L3_HUMAN (1-152): 5.62e-66: 199: 55.26		AN36A_HUMAN (427-951): 3.13e-11: 70: 13.36