Protein: VRK2
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)

Gene: VRK2
Organism: Homo sapiens
Interactions: 225
UniProt ID: Q86Y07

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

894184

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.793

High

201360

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

5

Small-scale

0.789

High

972219

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

19

Small-scale

0.789

High

350311

RASK
GTPase KRas

2

20

High-throughput

0.754

High

1205047

FAF2
FAS-associated factor 2

4

3

High-throughput

0.694

High

153143

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

18

Small-scale

0.691

High

276257

CIB2
Calcium and integrin-binding family member 2

1

20

High-throughput

0.691

High

537755

INSRR
Insulin receptor-related protein

1

18

High-throughput

0.691

High

598973

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.691

High

800804

MK08
Mitogen-activated protein kinase 8

1

14

Small-scale

0.691

High

801230

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.691

High

1033500

ILK
Integrin-linked protein kinase

1

8

High-throughput

0.691

High

1074168

SF3A1
Splicing factor 3A subunit 1

1

4

High-throughput

0.691

High

360113

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

10

High-throughput

0.676

High

199927

SPIT2
Kunitz-type protease inhibitor 2

3

10

High-throughput

0.667

High

1205093

SRPRB
Signal recognition particle receptor subunit beta

3

8

High-throughput

0.667

High

1205018

KSR1
Kinase suppressor of Ras 1

1

18

Small-scale

0.665

High

861828

PLK1
Serine/threonine-protein kinase PLK1

1

17

Small-scale

0.647

High

884418

TMPS3
Transmembrane protease serine 3

2

6

High-throughput

0.628

High

1205039

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

7

High-throughput

0.628

High

63598

ASB14
Ankyrin repeat and SOCS box protein 14

1

2

High-throughput

0.618

High

156866

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.618

High

172097

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.618

High

666322

NK3R
Neuromedin-K receptor

1

2

High-throughput

0.618

High

1202685

P2RY8
P2Y purinoceptor 8

1

2

High-throughput

0.618

High

1205094

GPR45
Probable G-protein coupled receptor 45

1

9

High-throughput

0.618

High

120520

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

149014

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.618

High

169186

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

19

High-throughput

0.618

High

374485

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

411424

INSR
Insulin receptor

1

14

High-throughput

0.618

High

434232

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

19

High-throughput

0.618

High

436388

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

545478

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

568726

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

18

High-throughput

0.618

High

591612

RAB3B
Ras-related protein Rab-3B

1

6

High-throughput

0.618

High

592355

RAB5A
Ras-related protein Rab-5A

1

12

High-throughput

0.618

High

665494

EPHA8
Ephrin type-A receptor 8

1

13

High-throughput

0.618

High

845053

RAB7A
Ras-related protein Rab-7a

1

13

High-throughput

0.618

High

845583

RAB9A
Ras-related protein Rab-9A

1

15

High-throughput

0.618

High

852543

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

892467

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

900655

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

901193

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

914187

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.618

High

919150

RAN
GTP-binding nuclear protein Ran

1

15

Small-scale

0.618

High

925409

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

940482

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.618

High

951129

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1053057

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

17

High-throughput

0.618

High

1076645

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1081524

NTRK3
NT-3 growth factor receptor

1

18

High-throughput

0.618

High

1167883

DJC14
DnaJ homolog subfamily C member 14

1

8

High-throughput

0.618

High

1205020

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.618

High

1205030

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.618

High

1205041

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1205053

DNJC1
DnaJ homolog subfamily C member 1

1

11

High-throughput

0.618

High

1205065

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.618

High

1205067

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1205068

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1205070

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1205085

SEC63
Translocation protein SEC63 homolog

1

4

High-throughput

0.618

High

1205089

DJC16
DnaJ homolog subfamily C member 16

1

12

High-throughput

0.618

High

390341

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.611

High

654505

CALX
Calnexin

2

4

High-throughput

0.611

High

1035251

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

12

Small-scale

0.598

High

1012150

Q0VAB0
Thromboxane A2 receptor

1

2

High-throughput

0.594

High

391000

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.585

High

507104

LAMP1
Lysosome-associated membrane glycoprotein 1

2

13

High-throughput

0.584

High

1205024

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1205076

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.580

High

1205048

DTBP1
Dysbindin

1

4

Small-scale

0.578

High

369942

ESR1
Estrogen receptor

2

16

High-throughput

0.571

High

387038

P53
Cellular tumor antigen p53

1

7

Small-scale

0.561

High

890241

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

600900

TA2R
Thromboxane A2 receptor

1

5

High-throughput

0.555

High

734383

CXA5
Gap junction alpha-5 protein

2

9

High-throughput

0.553

High

1037625

AQP6
Aquaporin-6

2

2

High-throughput

0.553

High

591914

RAB4A
Ras-related protein Rab-4A

1

11

High-throughput

0.553

High

793379

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.553

High

844599

RAB5C
Ras-related protein Rab-5C

1

11

High-throughput

0.553

High

884529

RAB25
Ras-related protein Rab-25

1

7

High-throughput

0.553

High

1070279

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.553

High

1205025

DJC22
DnaJ homolog subfamily C member 22

1

7

High-throughput

0.553

High

307261

RCBT2
RCC1 and BTB domain-containing protein 2

1

6

High-throughput

0.536

High

364954

FRIL
Ferritin light chain

1

6

High-throughput

0.536

High

448724

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

513747

CP19A
Aromatase

1

3

High-throughput

0.536

High

558749

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

3

High-throughput

0.536

High

570855

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.536

High

703526

CP2CI
Cytochrome P450 2C18

1

4

High-throughput

0.536

High

1015992

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

16

High-throughput

0.536

High

1108429

PTHD3
Patched domain-containing protein 3

1

3

High-throughput

0.536

High

1205040

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

3

High-throughput

0.536

High

1205062

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

High-throughput

0.536

High

1205072

CP26B
Cytochrome P450 26B1

1

2

High-throughput

0.536

High

1205087

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

3

Small-scale

0.536

High

1205095

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

473139

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

763036

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

792806

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

1053780

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1092762

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

1125041

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1205033

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1205034

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

1205037

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.513

High

1205044

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1205061

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

High-throughput

0.513

High

175018

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

573349

TCPA
T-complex protein 1 subunit alpha

1

7

Small-scale

0.501

High

750338

COIL
Coilin

1

2

Small-scale

0.501

High

843275

TCPD
T-complex protein 1 subunit delta

1

7

Small-scale

0.501

High

921330

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.501

High

1032924

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

7

Small-scale

0.501

High

992097

B2CL1
Bcl-2-like protein 1

1

2

Small-scale

0.500

High

656374

DMB
HLA class II histocompatibility antigen, DM beta chain

1

1

High-throughput

0.489

High

825069

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.489

High

885932

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.489

High

923880

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

7

High-throughput

0.489

High

1047582

KCNC3
Potassium voltage-gated channel subfamily C member 3

1

5

High-throughput

0.489

High

1203462

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

1205026

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

1

High-throughput

0.489

High

1205050

TSN17
Tetraspanin-17

1

2

High-throughput

0.489

High

1205078

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

1205082

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

2

High-throughput

0.489

High

1205092

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.489

High

943330

TCPB
T-complex protein 1 subunit beta

1

11

Small-scale

0.481

High

1205032

LNX1
E3 ubiquitin-protein ligase LNX

1

8

Small-scale

0.481

High

48409

ESYT2
Extended synaptotagmin-2

1

7

High-throughput

0.479

High

163870

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.479

High

273878

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

282951

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

11

High-throughput

0.479

High

315202

CNEP1
CTD nuclear envelope phosphatase 1

1

3

High-throughput

0.479

High

347229

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.479

High

514701

CP2C9
Cytochrome P450 2C9

1

4

High-throughput

0.479

High

527586

LAMP2
Lysosome-associated membrane glycoprotein 2

1

13

High-throughput

0.479

High

567147

CXA1
Gap junction alpha-1 protein

1

9

High-throughput

0.479

High

573782

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

High-throughput

0.479

High

595291

LMNB1
Lamin-B1

1

10

High-throughput

0.479

High

670097

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

786001

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

825462

LMAN1
Protein ERGIC-53

1

3

High-throughput

0.479

High

838956

EMD
Emerin

1

4

High-throughput

0.479

High

847541

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

917538

H4
Histone H4

1

4

High-throughput

0.479

High

918493

H2B1C
Histone H2B type 1-C/E/F/G/I

1

13

High-throughput

0.479

High

922248

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

941124

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

959520

VIGLN
Vigilin

1

7

High-throughput

0.479

High

961715

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

990531

CKAP4
Cytoskeleton-associated protein 4

1

15

High-throughput

0.479

High

1017693

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1040156

STIM1
Stromal interaction molecule 1

1

2

High-throughput

0.479

High

1084082

OCLN
Occludin

1

5

High-throughput

0.479

High

1135085

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

4

High-throughput

0.479

High

1156623

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

1162083

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1168562

SYNE3
Nesprin-3

1

9

High-throughput

0.479

High

1188274

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1188515

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1205028

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1205031

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1205036

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.479

High

1205042

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1205043

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

1205046

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1205051

TECT2
Tectonic-2

1

1

High-throughput

0.479

High

1205052

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1205054

PANX1
Pannexin-1

1

2

High-throughput

0.479

High

1205055

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

2

High-throughput

0.479

High

1205056

RMD3
Regulator of microtubule dynamics protein 3

1

4

High-throughput

0.479

High

1205059

ESYT1
Extended synaptotagmin-1

1

6

High-throughput

0.479

High

1205063

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

1205066

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.479

High

1205077

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

1205083

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1205084

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1205090

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

486566

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

795186

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

1126102

MKS3
Meckelin

1

0

High-throughput

0.458

High

1165729

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1199588

LBN
Limbin

1

0

High-throughput

0.458

High

1205019

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1205057

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1205060

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1205064

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1205069

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1205073

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1205079

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

1205080

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

489437

BCL2
Apoptosis regulator Bcl-2

1

2

Small-scale

0.457

High

992015

BAX
Apoptosis regulator BAX

1

2

Small-scale

0.445

High

1205029

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

132523

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

177932

TMPS2
Transmembrane protease serine 2

1

7

High-throughput

0.437

High

178638

STX7
Syntaxin-7

1

6

High-throughput

0.437

High

824162

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.437

High

912977

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.437

High

1087560

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.437

High

1198084

TM11B
Transmembrane protease serine 11B

1

7

High-throughput

0.437

High

1203753

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

1205022

CXD3
Gap junction delta-3 protein

1

9

High-throughput

0.437

High

1205075

TMPS4
Transmembrane protease serine 4

1

7

High-throughput

0.437

High

1205086

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

1205088

LAMP3
Lysosome-associated membrane glycoprotein 3

1

13

High-throughput

0.437

High

1089294

F187B
Protein FAM187B

3

0

High-throughput

0.347

High

1161195

TMM88
Transmembrane protein 88

2

0

High-throughput

0.316

High

1165134

TM205
Transmembrane protein 205

2

0

High-throughput

0.316

High

203385

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

0

High-throughput

0.279

Low

1139684

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

1205021

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

1205023

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1205027

KTAP2
Keratinocyte-associated protein 2

1

0

High-throughput

0.279

Low

1205035

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1205038

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1205049

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1205058

PADC1
Protease-associated domain-containing protein 1

1

0

High-throughput

0.279

Low

1205071

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1204275

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1205045

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1205074

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1205081

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1205091

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024