Download interactions: TXT MITAB-2.5
| Interaction | Interactor | Experiments | Homologs | Category | Interaction Score |
Confidence |
|---|---|---|---|---|---|---|
|
PRKN
E3 ubiquitin-protein ligase parkin |
58 |
20 |
Small-scale |
0.997 | High |
|
|
UBE3A
Ubiquitin-protein ligase E3A |
35 |
20 |
Small-scale |
0.994 | High |
|
|
ARI1
E3 ubiquitin-protein ligase ARIH1 |
20 |
20 |
Small-scale |
0.991 | High |
|
|
UBA1
Ubiquitin-like modifier-activating enzyme 1 |
24 |
20 |
Small-scale |
0.991 | High |
|
|
ITCH
E3 ubiquitin-protein ligase Itchy homolog |
21 |
20 |
Small-scale |
0.989 | High |
|
|
ARI2
E3 ubiquitin-protein ligase ARIH2 |
16 |
20 |
Small-scale |
0.988 | High |
|
|
NEDD4
E3 ubiquitin-protein ligase NEDD4 |
19 |
20 |
Small-scale |
0.987 | High |
|
|
HUWE1
E3 ubiquitin-protein ligase HUWE1 |
12 |
20 |
Small-scale |
0.979 | High |
|
|
RNF31
E3 ubiquitin-protein ligase RNF31 |
12 |
20 |
Small-scale |
0.978 | High |
|
|
SMUF2
E3 ubiquitin-protein ligase SMURF2 |
11 |
20 |
Small-scale |
0.978 | High |
|
|
WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2 |
11 |
20 |
Small-scale |
0.976 | High |
|
|
NED4L
E3 ubiquitin-protein ligase NEDD4-like |
11 |
20 |
Small-scale |
0.976 | High |
|
|
SMUF1
E3 ubiquitin-protein ligase SMURF1 |
11 |
20 |
Small-scale |
0.976 | High |
|
|
HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1 |
10 |
20 |
Small-scale |
0.975 | High |
|
|
RBX1
E3 ubiquitin-protein ligase RBX1 |
10 |
20 |
Small-scale |
0.973 | High |
|
|
WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1 |
9 |
20 |
Small-scale |
0.969 | High |
|
|
HACE1
E3 ubiquitin-protein ligase HACE1 |
8 |
20 |
Small-scale |
0.968 | High |
|
|
CBL
E3 ubiquitin-protein ligase CBL |
7 |
15 |
Small-scale |
0.957 | High |
|
|
R144A
E3 ubiquitin-protein ligase RNF144A |
6 |
20 |
Small-scale |
0.947 | High |
|
|
UBR5
E3 ubiquitin-protein ligase UBR5 |
6 |
20 |
Small-scale |
0.942 | High |
|
|
UBE3C
Ubiquitin-protein ligase E3C |
6 |
20 |
Small-scale |
0.942 | High |
|
|
TRIPC
E3 ubiquitin-protein ligase TRIP12 |
5 |
20 |
Small-scale |
0.919 | High |
|
|
CHIP
E3 ubiquitin-protein ligase CHIP |
4 |
15 |
Small-scale |
0.893 | High |
|
|
UBA6
Ubiquitin-like modifier-activating enzyme 6 |
4 |
20 |
Small-scale |
0.888 | High |
|
|
AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1 |
4 |
20 |
Small-scale |
0.888 | High |
|
|
TRAF6
TNF receptor-associated factor 6 |
4 |
20 |
Small-scale |
0.885 | High |
|
|
OTUB1
Ubiquitin thioesterase OTUB1 |
4 |
9 |
Small-scale |
0.873 | High |
|
|
RNF37
RING finger protein 37 |
3 |
7 |
Small-scale |
0.873 | High |
|
|
TRI18
E3 ubiquitin-protein ligase Midline-1 |
3 |
20 |
High-throughput |
0.861 | High |
|
|
MDM2
E3 ubiquitin-protein ligase Mdm2 |
3 |
13 |
Small-scale |
0.845 | High |
|
|
HERC3
Probable E3 ubiquitin-protein ligase HERC3 |
3 |
20 |
Small-scale |
0.845 | High |
|
|
CUL9
Cullin-9 |
3 |
20 |
Small-scale |
0.840 | High |
|
|
UBC
Polyubiquitin-C [Cleaved into: Ubiquitin] |
3 |
20 |
Small-scale |
0.834 | High |
|
|
RL40
Ubiquitin-ribosomal protein eL40 fusion protein |
3 |
20 |
High-throughput |
0.827 | High |
|
|
BRCA1
Breast cancer type 1 susceptibility protein |
2 |
20 |
Small-scale |
0.815 | High |
|
|
RN19B
E3 ubiquitin-protein ligase RNF19B |
2 |
20 |
Small-scale |
0.802 | High |
|
|
DTX3
Probable E3 ubiquitin-protein ligase DTX3 |
2 |
20 |
High-throughput |
0.800 | High |
|
|
R144B
E3 ubiquitin-protein ligase RNF144B |
2 |
20 |
Small-scale |
0.793 | High |
|
|
RN125
E3 ubiquitin-protein ligase RNF125 |
2 |
20 |
High-throughput |
0.791 | High |
|
|
UBA7
Ubiquitin-like modifier-activating enzyme 7 |
2 |
20 |
Small-scale |
0.778 | High |
|
|
HERC4
Probable E3 ubiquitin-protein ligase HERC4 |
2 |
20 |
Small-scale |
0.778 | High |
|
|
BRE1A
E3 ubiquitin-protein ligase BRE1A |
2 |
14 |
Small-scale |
0.778 | High |
|
|
RN213
E3 ubiquitin-protein ligase RNF213 |
2 |
2 |
Small-scale |
0.778 | High |
|
|
HERC6
Probable E3 ubiquitin-protein ligase HERC6 |
2 |
20 |
Small-scale |
0.778 | High |
|
|
HECW2
E3 ubiquitin-protein ligase HECW2 |
2 |
20 |
Small-scale |
0.778 | High |
|
|
XIAP
E3 ubiquitin-protein ligase XIAP |
2 |
20 |
Small-scale |
0.768 | High |
|
|
RN216
E3 ubiquitin-protein ligase RNF216 |
7 |
20 |
Small-scale |
0.744 | High |
|
|
MKRN3
E3 ubiquitin-protein ligase makorin-3 |
1 |
15 |
High-throughput |
0.698 | High |
|
|
TRAF7
E3 ubiquitin-protein ligase TRAF7 |
1 |
12 |
High-throughput |
0.698 | High |
|
|
CBLC
E3 ubiquitin-protein ligase CBL-C |
1 |
20 |
High-throughput |
0.698 | High |
|
|
UB2L3
Ubiquitin-conjugating enzyme E2 L3 |
1 |
16 |
Small-scale |
0.692 | High |
|
|
UBB
Polyubiquitin-B [Cleaved into: Ubiquitin] |
1 |
20 |
High-throughput |
0.691 | High |
|
|
FBXW2
F-box/WD repeat-containing protein 2 |
1 |
11 |
High-throughput |
0.691 | High |
|
|
RN19A
E3 ubiquitin-protein ligase RNF19A |
4 |
20 |
Small-scale |
0.686 | High |
|
|
BIRC3
Baculoviral IAP repeat-containing protein 3 |
1 |
20 |
Small-scale |
0.665 | High |
|
|
BIRC2
Baculoviral IAP repeat-containing protein 2 |
1 |
20 |
Small-scale |
0.665 | High |
|
|
MEX3A
RNA-binding protein MEX3A |
1 |
6 |
High-throughput |
0.647 | High |
|
|
F8VWT9
HECT domain E3 ubiquitin protein ligase 4 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
TRI13
E3 ubiquitin-protein ligase TRIM13 |
1 |
20 |
Small-scale |
0.647 | High |
|
|
PIAS1
E3 SUMO-protein ligase PIAS1 |
1 |
1 |
High-throughput |
0.647 | High |
|
|
PIAS2
E3 SUMO-protein ligase PIAS2 |
1 |
1 |
High-throughput |
0.647 | High |
|
|
HERC2
E3 ubiquitin-protein ligase HERC2 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
RO52
E3 ubiquitin-protein ligase TRIM21 |
1 |
20 |
Small-scale |
0.647 | High |
|
|
TRI23
E3 ubiquitin-protein ligase TRIM23 |
1 |
7 |
High-throughput |
0.647 | High |
|
|
CBLB
E3 ubiquitin-protein ligase CBL-B |
1 |
14 |
High-throughput |
0.647 | High |
|
|
TRI25
E3 ubiquitin/ISG15 ligase TRIM25 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
HERC1
Probable E3 ubiquitin-protein ligase HERC1 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
UBR4
E3 ubiquitin-protein ligase UBR4 |
1 |
11 |
High-throughput |
0.647 | High |
|
|
MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C |
1 |
20 |
High-throughput |
0.647 | High |
|
|
HECD2
Probable E3 ubiquitin-protein ligase HECTD2 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
RN220
E3 ubiquitin-protein ligase RNF220 |
1 |
8 |
High-throughput |
0.647 | High |
|
|
RN111
E3 ubiquitin-protein ligase Arkadia |
1 |
20 |
Small-scale |
0.647 | High |
|
|
HECW1
E3 ubiquitin-protein ligase HECW1 |
1 |
20 |
Small-scale |
0.647 | High |
|
|
BRAP
BRCA1-associated protein |
1 |
7 |
High-throughput |
0.647 | High |
|
|
RN168
E3 ubiquitin-protein ligase RNF168 |
1 |
7 |
High-throughput |
0.647 | High |
|
|
PJA1
E3 ubiquitin-protein ligase Praja-1 |
1 |
20 |
Small-scale |
0.647 | High |
|
|
CUL5
Cullin-5 |
1 |
15 |
Small-scale |
0.647 | High |
|
|
RING2
E3 ubiquitin-protein ligase RING2 |
1 |
20 |
Small-scale |
0.647 | High |
|
|
TRI55
Tripartite motif-containing protein 55 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
UBA5
Ubiquitin-like modifier-activating enzyme 5 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
VPS11
Vacuolar protein sorting-associated protein 11 homolog |
1 |
4 |
High-throughput |
0.647 | High |
|
|
AKIB1
Ankyrin repeat and IBR domain-containing protein 1 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
RBX2
RING-box protein 2 |
1 |
20 |
Small-scale |
0.647 | High |
|
|
RNF14
E3 ubiquitin-protein ligase RNF14 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
RN150
RING finger protein 150 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
HECD1
E3 ubiquitin-protein ligase HECTD1 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
RN114
E3 ubiquitin-protein ligase RNF114 |
1 |
20 |
High-throughput |
0.647 | High |
|
|
R113B
RING finger protein 113B |
1 |
1 |
High-throughput |
0.625 | High |
|
|
RN103
E3 ubiquitin-protein ligase RNF103 |
1 |
20 |
Small-scale |
0.621 | High |
|
|
MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1 |
1 |
20 |
Small-scale |
0.621 | High |
|
|
MLP3B
Microtubule-associated protein 1 light chain 3 beta |
2 |
3 |
Small-scale |
0.620 | High |
|
|
UBE2H
Ubiquitin-conjugating enzyme E2 H |
1 |
16 |
High-throughput |
0.618 | High |
|
|
RS27A
Ubiquitin-ribosomal protein eS31 fusion protein |
1 |
20 |
High-throughput |
0.618 | High |
|
|
UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme |
1 |
17 |
High-throughput |
0.618 | High |
|
|
HERC5
E3 ISG15--protein ligase HERC5 |
1 |
20 |
Small-scale |
0.618 | High |
|
|
RNF11
RING finger protein 11 |
1 |
20 |
Small-scale |
0.618 | High |
|
|
ZN598
E3 ubiquitin-protein ligase ZNF598 |
2 |
5 |
High-throughput |
0.611 | High |
|
|
RN182
E3 ubiquitin-protein ligase RNF182 |
2 |
20 |
High-throughput |
0.606 | High |
|
|
MYCB2
E3 ubiquitin-protein ligase MYCBP2 |
2 |
20 |
Small-scale |
0.595 | High |
|
|
AN36A
Ankyrin repeat domain-containing protein 36A |
3 |
5 |
High-throughput |
0.585 | High |
|
|
CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B |
2 |
3 |
Small-scale |
0.584 | High |
|
|
RN170
E3 ubiquitin-protein ligase RNF170 |
1 |
2 |
High-throughput |
0.579 | High |
|
|
MLP3A
Microtubule-associated protein 1 light chain 3 alpha |
2 |
3 |
High-throughput |
0.571 | High |
|
|
GCR
Glucocorticoid receptor |
1 |
1 |
Small-scale |
0.552 | High |
|
|
TRI39
E3 ubiquitin-protein ligase TRIM39 |
1 |
20 |
High-throughput |
0.541 | High |
|
|
DNM1L
Dynamin-1-like protein |
1 |
1 |
High-throughput |
0.536 | High |
|
|
CIP1
E3 ubiquitin-protein ligase CCNB1IP1 |
1 |
0 |
Small-scale |
0.529 | High |
|
|
AURKA
Aurora kinase A |
1 |
1 |
High-throughput |
0.515 | High |
|
|
HSC20
Iron-sulfur cluster co-chaperone protein HscB |
1 |
0 |
High-throughput |
0.513 | High |
|
|
MK06
Mitogen-activated protein kinase 6 |
1 |
2 |
High-throughput |
0.508 | High |
|
|
LTN1
E3 ubiquitin-protein ligase listerin |
1 |
2 |
High-throughput |
0.501 | High |
|
|
FOS
Protein c-Fos |
1 |
2 |
Small-scale |
0.501 | High |
|
|
P53
Cellular tumor antigen p53 |
1 |
3 |
Small-scale |
0.501 | High |
|
|
RPB1
DNA-directed RNA polymerase II subunit RPB1 |
1 |
2 |
Small-scale |
0.501 | High |
|
|
IKBA
NF-kappa-B inhibitor alpha |
1 |
11 |
Small-scale |
0.501 | High |
|
|
HSP74
Heat shock 70 kDa protein 4 |
1 |
3 |
Small-scale |
0.501 | High |
|
|
CDN1B
Cyclin-dependent kinase inhibitor 1B |
1 |
2 |
Small-scale |
0.501 | High |
|
|
ATX3
Ataxin-3 |
1 |
1 |
Small-scale |
0.501 | High |
|
|
UBS3A
Ubiquitin-associated and SH3 domain-containing protein A |
1 |
7 |
Small-scale |
0.501 | High |
|
|
TF65
Transcription factor p65 |
1 |
9 |
Small-scale |
0.501 | High |
|
|
TIF1B
Transcription intermediary factor 1-beta |
1 |
20 |
Small-scale |
0.501 | High |
|
|
RC3H1
Roquin-1 |
1 |
5 |
Small-scale |
0.501 | High |
|
|
RTF2
Replication termination factor 2 |
1 |
1 |
High-throughput |
0.501 | High |
|
|
TRI31
E3 ubiquitin-protein ligase TRIM31 |
1 |
20 |
High-throughput |
0.501 | High |
|
|
MKRN2
E3 ubiquitin-protein ligase makorin-2 |
1 |
15 |
Small-scale |
0.501 | High |
|
|
FBX2
F-box only protein 2 |
1 |
4 |
Small-scale |
0.501 | High |
|
|
FINC
Fibronectin |
1 |
2 |
High-throughput |
0.489 | High |
|
|
CDC42
Cell division control protein 42 homolog |
1 |
0 |
High-throughput |
0.480 | High |
|
|
OTUD3
OTU domain-containing protein 3 |
1 |
0 |
Small-scale |
0.480 | High |
|
|
I2BP1
Interferon regulatory factor 2-binding protein 1 |
1 |
0 |
High-throughput |
0.480 | High |
|
|
CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A |
1 |
3 |
Small-scale |
0.479 | High |
|
|
CTRO
Citron Rho-interacting kinase |
1 |
3 |
High-throughput |
0.479 | High |
|
|
EIF1B
Eukaryotic translation initiation factor 1b |
1 |
1 |
High-throughput |
0.479 | High |
|
|
BRD4
Bromodomain-containing protein 4 |
1 |
8 |
High-throughput |
0.479 | High |
|
|
RECQ4
ATP-dependent DNA helicase Q4 |
1 |
1 |
High-throughput |
0.479 | High |
|
|
EYA4
Protein phosphatase EYA4 |
1 |
2 |
High-throughput |
0.479 | High |
|
|
BAG3
BAG family molecular chaperone regulator 3 |
1 |
1 |
High-throughput |
0.479 | High |
|
|
HSP7C
Heat shock cognate 71 kDa protein |
1 |
3 |
High-throughput |
0.479 | High |
|
|
EPB41
Protein 4.1 |
1 |
1 |
High-throughput |
0.479 | High |
|
|
TCTP
Translationally-controlled tumor protein |
1 |
5 |
High-throughput |
0.479 | High |
|
|
VHL
von Hippel-Lindau disease tumor suppressor |
1 |
3 |
High-throughput |
0.479 | High |
|
|
CCNF
Cyclin-F |
1 |
4 |
High-throughput |
0.479 | High |
|
|
MCM2
DNA replication licensing factor MCM2 |
1 |
5 |
High-throughput |
0.479 | High |
|
|
TP53B
TP53-binding protein 1 |
1 |
5 |
Small-scale |
0.479 | High |
|
|
DUS4
Dual specificity protein phosphatase 4 |
1 |
3 |
High-throughput |
0.479 | High |
|
|
DUS8
Dual specificity protein phosphatase 8 |
1 |
3 |
High-throughput |
0.479 | High |
|
|
SKP2
S-phase kinase-associated protein 2 |
1 |
7 |
Small-scale |
0.479 | High |
|
|
U5S1
116 kDa U5 small nuclear ribonucleoprotein component |
1 |
1 |
High-throughput |
0.479 | High |
|
|
NCOA1
Nuclear receptor coactivator 1 |
1 |
1 |
Small-scale |
0.479 | High |
|
|
EZH2
Histone-lysine N-methyltransferase EZH2 |
1 |
2 |
High-throughput |
0.479 | High |
|
|
TRI67
Tripartite motif-containing protein 67 |
1 |
20 |
High-throughput |
0.479 | High |
|
|
TBCB
Tubulin-folding cofactor B |
1 |
1 |
High-throughput |
0.479 | High |
|
|
PKHA4
Pleckstrin homology domain-containing family A member 4 |
1 |
3 |
High-throughput |
0.479 | High |
|
|
HELLS
Lymphoid-specific helicase |
1 |
1 |
Small-scale |
0.479 | High |
|
|
PIHD1
PIH1 domain-containing protein 1 |
1 |
1 |
High-throughput |
0.479 | High |
|
|
ZRAN1
Ubiquitin thioesterase ZRANB1 |
1 |
15 |
High-throughput |
0.479 | High |
|
|
AAKB1
5'-AMP-activated protein kinase subunit beta-1 |
1 |
1 |
High-throughput |
0.479 | High |
|
|
DNLI4
DNA ligase 4 |
1 |
0 |
High-throughput |
0.460 | High |
|
|
MYPT1
Protein phosphatase 1 regulatory subunit 12A |
1 |
0 |
High-throughput |
0.458 | High |
|
|
IF4E2
Eukaryotic translation initiation factor 4E type 2 |
1 |
0 |
Small-scale |
0.458 | High |
|
|
MYC
Myc proto-oncogene protein |
1 |
0 |
Small-scale |
0.458 | High |
|
|
PARP1
Poly [ADP-ribose] polymerase 1 |
1 |
0 |
High-throughput |
0.458 | High |
|
|
PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
1 |
0 |
Small-scale |
0.458 | High |
|
|
BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1 |
1 |
0 |
High-throughput |
0.458 | High |
|
|
PINX1
PIN2/TERF1-interacting telomerase inhibitor 1 |
1 |
0 |
High-throughput |
0.458 | High |
|
|
NFIP1
NEDD4 family-interacting protein 1 |
1 |
0 |
Small-scale |
0.458 | High |
|
|
AICDA
Single-stranded DNA cytosine deaminase |
1 |
0 |
Small-scale |
0.458 | High |
|
|
NUFP1
FMR1-interacting protein NUFIP1 |
1 |
0 |
High-throughput |
0.458 | High |
|
|
TAU
Microtubule-associated protein tau |
1 |
4 |
High-throughput |
0.445 | High |
|
|
NFKB1
Nuclear factor NF-kappa-B p105 subunit |
1 |
17 |
High-throughput |
0.445 | High |
|
|
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2 |
1 |
5 |
High-throughput |
0.445 | High |
|
|
RL19
Large ribosomal subunit protein eL19 |
1 |
0 |
High-throughput |
0.438 | High |
|
|
JUN
Transcription factor Jun |
1 |
0 |
High-throughput |
0.426 | High |
|
|
CFTR
Cystic fibrosis transmembrane conductance regulator |
1 |
0 |
High-throughput |
0.426 | High |
|
|
NCBP3
Nuclear cap-binding protein subunit 3 |
1 |
0 |
High-throughput |
0.426 | High |
|
|
SMAD7
Mothers against decapentaplegic homolog 7 |
1 |
1 |
Small-scale |
0.408 | High |
|
|
AAR2
Protein AAR2 homolog |
1 |
0 |
High-throughput |
0.249 | Low |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
