Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS
Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 0.60 | 0.750 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11285248, 10861283, 12444101, 29997244, 12444102, unassigned1913, 11779178, 32814053 |
| Identification Methods | pull down, affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, anti bait coimmunoprecipitation, split luciferase complementation, protein complementation assay, luminescence based mammalian interactome mapping |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005769 - early endosome GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation GO:0046426 - negative regulation of receptor signaling pathway via JAK-STAT |
| Homologous interactions | 6 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
