Protein: HRS
Hepatocyte growth factor-regulated tyrosine kinase substrate

Gene: HRS
Organism: Drosophila melanogaster
Interactions: 54
UniProt ID: Q960X8

Gene Ontology (top 5):
GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005938 - cell cortex
GO:0006897 - endocytosis
GO:0006898 - receptor-mediated endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1379165

Q9XTL2
Jak pathway signal transduction adaptor molecule

3

17

High-throughput

0.852

High

1343697

MIDN
Midnolin homolog

1

1

High-throughput

0.625

High

1379149

Q9VDD8
Ubiquitin carboxyl-terminal hydrolase

1

8

Small-scale

0.561

High

509803

UBIQP
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

Small-scale

0.553

High

715129

CLH
Clathrin heavy chain

1

17

High-throughput

0.541

High

875351

DIA
Protein diaphanous

1

4

High-throughput

0.541

High

1267300

Q7KLE5
Amphiphysin

1

4

High-throughput

0.541

High

1379152

Q9VH60
F-box only protein 11

1

3

High-throughput

0.541

High

1379163

Q9W277
Vacuolar protein sorting-associated protein 35

1

2

High-throughput

0.541

High

477359

TOLL
Protein toll

1

3

Small-scale

0.536

High

1379158

Q9VUH6
Myopic

1

13

Small-scale

0.536

High

57053

A1ZAN6
Rho guanine nucleotide exchange factor 2, isoform D

1

6

High-throughput

0.494

High

612395

ACTN
Alpha-actinin, sarcomeric

1

6

High-throughput

0.494

High

1028083

SPTCB
Spectrin beta chain

1

7

High-throughput

0.494

High

1040523

CACT
NF-kappa-B inhibitor cactus

1

10

High-throughput

0.494

High

1268027

Q7KN74
Tetratricopeptide repeat domain 7, isoform A

1

5

High-throughput

0.494

High

1379147

Q9VC36
Polybromo

1

3

High-throughput

0.494

High

1379148

Q9VCB8
SD25546p

1

5

High-throughput

0.494

High

1379150

FLNA
Filamin-A

1

9

High-throughput

0.494

High

1379157

Q9VPL5
TBC1 domain family member 15

1

2

High-throughput

0.494

High

1379159

DTBP1
Dysbindin protein homolog

1

2

High-throughput

0.494

High

1379160

MED12
Mediator of RNA polymerase II transcription subunit 12

1

3

High-throughput

0.494

High

1379166

TFP11
Septin-interacting protein 1

1

1

High-throughput

0.494

High

1379151

Q9VGU4
FI02822p

1

8

High-throughput

0.489

High

1379156

Q9VNS1
UT01871p

1

0

High-throughput

0.486

High

1379164

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.486

High

121051

M9PEP8
Muscle-specific protein 300 kDa, isoform M

1

5

High-throughput

0.481

High

1173331

DIAP2
Death-associated inhibitor of apoptosis 2

1

3

High-throughput

0.479

High

234485

CTBP
C-terminal-binding protein

1

5

High-throughput

0.464

High

235219

HTH
Homeobox protein homothorax

1

3

High-throughput

0.464

High

660458

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.464

High

1343662

Q8SXA8
GH18470p

1

1

High-throughput

0.457

High

1178555

Q2M1E6
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

6

High-throughput

0.439

High

1275265

Q7YZA0
Trio, isoform B

1

8

High-throughput

0.439

High

1304520

Q8IPE8
Trifunctional enzyme subunit alpha, mitochondrial

1

2

High-throughput

0.439

High

1379161

Q9VWJ6
FI03615p

1

2

High-throughput

0.439

High

753730

FAT
Cadherin-related tumor suppressor

1

2

High-throughput

0.437

High

1269046

Q7KSK8
BcDNA.GH09045

1

5

High-throughput

0.437

High

55697

A1Z9J3
Short stop, isoform H

1

5

High-throughput

0.417

High

1275203

Q7YU91
SD16537p

1

2

High-throughput

0.417

High

1305671

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.417

High

1346395

Q8T987
SD08659p

1

8

High-throughput

0.417

High

1379144

Q9V397
Trifunctional enzyme subunit alpha, mitochondrial

1

2

High-throughput

0.417

High

1379155

Q9VN68
Moesin/ezrin/radixin homolog 1

1

5

High-throughput

0.417

High

1019401

SMO
Protein smoothened

2

0

Small-scale

0.305

High

145973

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.282

High

458856

SRYA
Serendipity locus protein alpha

1

0

High-throughput

0.282

High

929211

FOJO
Extracellular serine/threonine protein kinase four-jointed

1

0

High-throughput

0.282

High

1171610

SNAP
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.282

High

1379145

DCUP
Uroporphyrinogen decarboxylase

1

0

High-throughput

0.282

High

1379154

HEAT1
HEAT repeat-containing protein 1 homolog

1

0

High-throughput

0.282

High

1379162

ANX11
Annexin B11

1

0

High-throughput

0.282

High

1379146

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.265

Low

1379153

Q9VLJ5
AT07979p2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025