HitPredict

Interactor 1: AXIN1 (O15169)
Axin-1 (Axis inhibition protein 1) (hAxin)
Gene: AXIN1

Interactor 2: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	24135036, 11884395, 10829020, 20128690, 22682247
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RGS
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 862 Hs			1 1512
+	Mm
		101502 AXIN1_MOUSE (1-862): 0: 1069: 86.97		F8VQ72_MOUSE (1-1512): 0: 1937: 88.41
+	Hs
		170740 AXIN1_HUMAN (1-862): 0: 1135: 100.00		M3K2_HUMAN (1238-1505): 3.52e-50: 191: 42.13
+	Hs
		170746 AXIN1_HUMAN (1-862): 0: 1135: 100.00		M3K4_HUMAN (1242-1505): 6.41e-38: 158: 33.21
+	Hs
		566509 AXIN2_HUMAN (11-862): 0: 835: 42.47		KPCA_HUMAN (963-1509): 9.28e-133: 428: 18.93
+	Hs
		1377394 AXIN2_HUMAN (11-862): 0: 835: 42.47		M3K2_HUMAN (1238-1505): 3.52e-50: 191: 42.13
+	Mm
		593481 RGS14_MOUSE (45-330): 3.14e-65: 230: 22.76		KPCA_MOUSE (963-1509): 1.4e-132: 427: 18.54
+	Hs
		566314 RGS2_HUMAN (24-219): 7.08e-52: 182: 22.28		KPCA_HUMAN (963-1509): 9.28e-133: 428: 18.93
+	Hs
		408572 RGS2_HUMAN (24-219): 7.08e-52: 182: 22.28		KPCB_HUMAN (899-1509): 2.67e-127: 413: 15.40
+	Hs
		397146 RGS2_HUMAN (24-219): 7.08e-52: 182: 22.28		KPCG_HUMAN (899-1509): 4.13e-124: 405: 16.04