Protein: PPAP
Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]

Gene: PPAP, ACP3
Organism: Homo sapiens
Interactions: 149
UniProt ID: P15309

Gene Ontology (top 5):
GO:0003993 - acid phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005765 - lysosomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

582541

PPAP
Prostatic acid phosphatase

3

5

Small-scale

0.843

High

582593

IL31R
Interleukin-31 receptor subunit alpha

2

1

High-throughput

0.628

High

582641

FBXL4
F-box/LRR-repeat protein 4

2

1

High-throughput

0.628

High

231096

AIRE
Autoimmune regulator

2

0

High-throughput

0.602

High

376971

ANF
Natriuretic peptides A

2

0

High-throughput

0.602

High

391557

FRIH
Ferritin heavy chain

2

0

High-throughput

0.602

High

582574

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.602

High

582588

DAA19
Dynein axonemal assembly factor 19

2

0

High-throughput

0.602

High

582599

CPLX3
Complexin-3

2

0

High-throughput

0.602

High

582610

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

582646

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.602

High

582622

DUS21
Dual specificity protein phosphatase 21

2

0

High-throughput

0.595

High

292538

RENR
Renin receptor

2

0

High-throughput

0.585

High

552110

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.536

High

582604

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

582647

RN115
E3 ubiquitin-protein ligase RNF115

1

1

High-throughput

0.536

High

133844

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.513

High

168185

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.513

High

214116

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

222350

TSN6
Tetraspanin-6

1

0

High-throughput

0.513

High

282664

E2F6
Transcription factor E2F6

1

0

High-throughput

0.513

High

301792

ANXA9
Annexin A9

1

0

High-throughput

0.513

High

317509

TPPP
Tubulin polymerization-promoting protein

1

0

High-throughput

0.513

High

331626

MBD4
Methyl-CpG-binding domain protein 4

1

0

High-throughput

0.513

High

352677

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

370537

FOS
Protein c-Fos

1

0

High-throughput

0.513

High

420229

IFNW1
Interferon omega-1

1

0

High-throughput

0.513

High

477327

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.513

High

582542

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

582543

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.513

High

582544

CCNC
Cyclin-C

1

0

High-throughput

0.513

High

582549

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

582556

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

582557

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

582564

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

582565

DSCR6
Protein ripply3

1

0

High-throughput

0.513

High

582567

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

582570

GABPA
GA-binding protein alpha chain

1

0

High-throughput

0.513

High

582576

LRC10
Leucine-rich repeat-containing protein 10

1

0

High-throughput

0.513

High

582585

ZN550
Zinc finger protein 550

1

0

High-throughput

0.513

High

582587

LACC1
Purine nucleoside phosphorylase LACC1

1

0

High-throughput

0.513

High

582612

FCRL5
Fc receptor-like protein 5

1

0

High-throughput

0.513

High

582614

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

582618

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

582619

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

582621

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

582626

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

582630

KLH11
Kelch-like protein 11

1

0

High-throughput

0.513

High

582631

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.513

High

582635

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.513

High

582639

PHF11
PHD finger protein 11

1

0

High-throughput

0.513

High

582644

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

582623

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

172449

XPO1
Exportin-1

1

4

High-throughput

0.479

High

220854

XPOT
Exportin-T

1

4

High-throughput

0.479

High

407833

SEMG1
Semenogelin-1

1

1

High-throughput

0.479

High

452152

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.479

High

455631

KLK3
Prostate-specific antigen

1

3

High-throughput

0.479

High

457945

TRY1
Serine protease 1

1

2

High-throughput

0.479

High

507493

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

582545

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.479

High

582546

CALR
Calreticulin

1

6

High-throughput

0.479

High

582547

CALX
Calnexin

1

6

High-throughput

0.479

High

582548

PDIA3
Protein disulfide-isomerase A3

1

6

High-throughput

0.479

High

582553

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.479

High

582559

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

582560

EFNA3
Ephrin-A3

1

3

High-throughput

0.479

High

582561

EFNA4
Ephrin-A4

1

3

High-throughput

0.479

High

582562

XPO2
Exportin-2

1

2

High-throughput

0.479

High

582568

SEMG2
Semenogelin-2

1

1

High-throughput

0.479

High

582579

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.479

High

582600

GCN1
Stalled ribosome sensor GCN1

1

3

High-throughput

0.479

High

582603

TNPO1
Transportin-1

1

1

High-throughput

0.479

High

582624

XPO5
Exportin-5

1

4

High-throughput

0.479

High

582648

TNPO3
Transportin-3

1

4

High-throughput

0.479

High

410580

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

Small-scale

0.463

High

407786

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

321172

ERLN2
Erlin-2

1

0

High-throughput

0.458

High

465833

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.458

High

467350

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

468985

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.458

High

582552

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.458

High

582554

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

582563

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

582572

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.458

High

582577

S27A3
Long-chain fatty acid transport protein 3

1

0

High-throughput

0.458

High

582586

MON2
Protein MON2 homolog

1

0

High-throughput

0.458

High

582589

ABD12
Lysophosphatidylserine lipase ABHD12

1

0

High-throughput

0.458

High

582594

CIP2A
Protein CIP2A

1

0

High-throughput

0.458

High

582601

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

582602

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.458

High

582606

ASTRA
Protein Aster-A

1

0

High-throughput

0.458

High

582609

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.458

High

582616

TMM43
Transmembrane protein 43

1

0

High-throughput

0.458

High

582620

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

582629

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.458

High

582634

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.458

High

582637

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.458

High

582642

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.458

High

582550

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

1

High-throughput

0.445

High

582640

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

2

High-throughput

0.445

High

170647

CLGN
Calmegin

1

6

High-throughput

0.437

High

582555

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.437

High

582566

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.437

High

582595

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.437

High

582638

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.437

High

582643

DJC16
DnaJ homolog subfamily C member 16

1

4

High-throughput

0.437

High

261075

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

379486

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

406958

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.426

High

582608

ASB9
Ankyrin repeat and SOCS box protein 9

1

0

High-throughput

0.426

High

582613

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.426

High

582571

MMRN1
Multimerin-1

3

0

High-throughput

0.347

High

582628

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

582645

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

51525

PL8L1
PLAC8-like protein 1

1

0

High-throughput

0.279

Low

229208

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.279

Low

325275

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

582551

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

582558

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

582569

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.279

Low

582575

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

582583

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

582591

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

582596

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

582605

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

582611

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

582615

SH23A
SH2 domain-containing protein 3A

1

0

High-throughput

0.279

Low

582617

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

582625

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

582627

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

582633

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.279

Low

105260

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

417930

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

582573

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.249

Low

582578

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.249

Low

582580

BSPRY
B box and SPRY domain-containing protein

1

0

High-throughput

0.249

Low

582581

ATLA3
Atlastin-3

1

0

High-throughput

0.249

Low

582584

5MP2
eIF5-mimic protein 2

1

0

High-throughput

0.249

Low

582590

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

582592

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.249

Low

582597

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.249

Low

582598

THEM6
Protein THEM6

1

0

High-throughput

0.249

Low

582607

FAF2
FAS-associated factor 2

1

0

High-throughput

0.249

Low

582632

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low

582636

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.249

Low

505280

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low

582582

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025