HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26673895, 33545068
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 440
+	Xl
		1237660 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q6PGS1_XENLA (3-438): 0: 668: 52.50
+	Hs
		1107993 TNPO1_HUMAN (33-1045): 1.82e-132: 425: 13.84		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Mm
		1225678 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Hs
		172374 XPO1_HUMAN (1-1071): 0: 1022: 100.00		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50
+	Hs
		1107725 IMB1_HUMAN (27-908): 2.9e-90: 311: 11.32		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1108326 TNPO3_HUMAN (24-901): 9.97e-89: 307: 14.37		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1295591 XPO7_HUMAN (23-1013): 1.49e-120: 398: 13.18		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Hs
		1295565 XPO5_HUMAN (26-665): 5.82e-100: 344: 16.12		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Hs
		1383742 XPO7_HUMAN (23-1013): 1.49e-120: 398: 13.18		MIB2_HUMAN (106-264): 3.56e-23: 104: 26.09
+	Hs
		1128721 IMB1_HUMAN (27-908): 2.9e-90: 311: 11.32		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78