HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: CEBPD (P49716)
CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta)
Gene: CEBPD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	18619497, 17910034
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006366 - transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 269
+	Hs
		831885 HDAC1_HUMAN (3-385): 0: 588: 62.92		CEBPD_HUMAN (1-269): 4.82e-77: 236: 100.00
+	Hs
		177235 HDAC3_HUMAN (1-428): 0: 600: 100.00		CEBPA_HUMAN (16-265): 1.09e-45: 158: 26.67
+	Rn
		403726 HDAC3_RAT (1-428): 0: 601: 99.77		CEBPA_RAT (16-265): 6.56e-42: 148: 27.02
+	Hs
		831299 HDAC1_HUMAN (3-385): 0: 588: 62.92		CEBPA_HUMAN (16-265): 1.09e-45: 158: 26.67
+	Hs
		177168 HDAC3_HUMAN (1-428): 0: 600: 100.00		JUN_HUMAN (37-254): 1.5e-38: 139: 16.18
+	Mm
		140244 HDAC1_MOUSE (3-385): 0: 588: 62.92		CEBPA_MOUSE (16-265): 2.4e-42: 150: 26.39
+	Hs
		831536 HDAC2_HUMAN (3-422): 0: 580: 58.63		CEBPA_HUMAN (16-265): 1.09e-45: 158: 26.67
+	Mm
		404159 Q9JM08_MOUSE (1-428): 0: 595: 99.07		JUN_MOUSE (37-254): 5.97e-38: 137: 15.57
+	Mm
		862804 HDAC2_MOUSE (3-422): 0: 578: 58.39		CEBPA_MOUSE (16-265): 2.4e-42: 150: 26.39
+	Hs
		401956 HDAC1_HUMAN (3-385): 0: 588: 62.92		JUN_HUMAN (37-254): 1.5e-38: 139: 16.18
+	Hs
		402302 HDAC2_HUMAN (3-422): 0: 580: 58.63		JUN_HUMAN (37-254): 1.5e-38: 139: 16.18
+	Mm
		140216 HDAC1_MOUSE (3-385): 0: 588: 62.92		JUNB_MOUSE (22-254): 1.31e-33: 126: 16.53
+	Hs
		569696 HDAC1_HUMAN (3-385): 0: 588: 62.92		CEBPB_HUMAN (161-265): 5.26e-31: 119: 53.33
+	Mm
		450547 HDAC2_MOUSE (3-422): 0: 578: 58.39		JUNB_MOUSE (22-254): 1.31e-33: 126: 16.53
+	Hs
		569923 HDAC2_HUMAN (3-422): 0: 580: 58.63		CEBPB_HUMAN (161-265): 5.26e-31: 119: 53.33
+	Mm
		140234 HDAC1_MOUSE (3-385): 0: 588: 62.92		CEBPB_MOUSE (186-265): 1.75e-27: 109: 62.50
+	Sp
		223487 CLR6_SCHPO (3-403): 0: 541: 57.61		ATF1_SCHPO (143-266): 1.25e-22: 98.8: 19.36
+	Sp
		857023 CLR3_SCHPO (3-352): 6.19e-118: 360: 23.93		ATF1_SCHPO (143-266): 1.25e-22: 98.8: 19.36