HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0032008 - positive regulation of TOR signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 974
+	Hs
		1038419 HDAC1_HUMAN (3-385): 0: 588: 62.92		RBBP7_HUMAN (43-334): 3.53e-61: 216: 20.46
+	Mm
		140272 HDAC1_MOUSE (3-385): 0: 588: 62.92		RBBP7_MOUSE (43-328): 4.99e-61: 216: 20.54
+	Hs
		1083335 HDAC2_HUMAN (3-422): 0: 580: 58.63		RBBP7_HUMAN (43-334): 3.53e-61: 216: 20.46
+	Mm
		936398 HDAC2_MOUSE (3-422): 0: 578: 58.39		RBBP7_MOUSE (43-328): 4.99e-61: 216: 20.54
+	Hs
		177249 HDAC3_HUMAN (1-428): 0: 600: 100.00		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Hs
		177377 HDAC3_HUMAN (1-428): 0: 600: 100.00		TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16
+	Hs
		903202 HDAC1_HUMAN (3-385): 0: 588: 62.92		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Hs
		1038686 HDAC1_HUMAN (3-385): 0: 588: 62.92		TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16
+	Hs
		903404 HDAC2_HUMAN (3-422): 0: 580: 58.63		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Hs
		1270423 HDAC2_HUMAN (3-422): 0: 580: 58.63		TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16
+	Dm
		1182201 Q7KTS4_DROME (3-427): 0: 550: 65.67		EBI_DROME (142-485): 5.02e-44: 173: 14.05
+	Dm
		1279322 Q9VNC2_DROME (3-427): 0: 546: 65.44		EBI_DROME (142-485): 5.02e-44: 173: 14.05
+	Hs
		177278 HDAC3_HUMAN (1-428): 0: 600: 100.00		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39
+	Hs
		1270358 HDAC2_HUMAN (3-422): 0: 580: 58.63		FBXW7_HUMAN (219-506): 1.23e-21: 102: 12.93
+	Mm
		140271 HDAC1_MOUSE (3-385): 0: 588: 62.92		RBBP4_MOUSE (145-377): 1.33e-17: 88.4: 20.39
+	Hs
		997711 HDAC1_HUMAN (3-385): 0: 588: 62.92		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39
+	Hs
		997836 HDAC2_HUMAN (3-422): 0: 580: 58.63		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39
+	Hs
		1270370 HDAC2_HUMAN (3-422): 0: 580: 58.63		SNR40_HUMAN (268-503): 1.87e-17: 87.2: 9.09
+	Dm
		1099152 HDAC1_DROME (3-422): 0: 580: 56.74		CAF1_DROME (190-355): 4.25e-10: 65.3: 17.58
+	Ce
		184840 HDA1_CAEEL (3-427): 0: 550: 53.92		LIN53_CAEEL (104-371): 8.15e-17: 86.1: 19.07