HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	31101761, 21234523
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, SH2~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 509
+	Hs
		146580 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		411544 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		181765 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		181783 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		146668 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		181771 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		181770 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		412098 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		411545 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		146582 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		411553 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		411552 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		181824 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		BLK_HUMAN (1-509): 0: 557: 59.35
+	Hs
		181852 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ITK_HUMAN (7-500): 1.08e-177: 515: 33.33
+	Hs
		181753 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Dm
		337688 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		SRC64_DROME (39-507): 7.74e-179: 515: 46.33
+	Dm
		337701 Q9VJA1_DROME (26-210): 3.45e-43: 154: 23.00		SRC64_DROME (39-507): 7.74e-179: 515: 46.33
+	Hs
		181816 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TEC_HUMAN (7-503): 2.17e-169: 494: 32.56
+	Mm
		337630 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		ABL1_MOUSE (49-502): 5.34e-171: 513: 42.21
+	Hs
		147492 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		TXK_HUMAN (61-500): 3.54e-162: 471: 37.64