HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: INAR1 (P17181)
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Gene: IFNAR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.563

Property	Details
Experiments	29674694, 21757742
Identification Methods	unspecified method, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 557
+	Mm
		193343 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INAR1_MOUSE (18-548): 3.31e-113: 350: 48.97
+	Hs
		297881 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		NFASC_HUMAN (5-424): 3.3e-60: 218: 15.90
+	Hs
		297883 NCK1_HUMAN (17-175): 2.39e-36: 132: 21.25		NFASC_HUMAN (5-424): 3.3e-60: 218: 15.90
+	Mm
		645935 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		IL3B2_MOUSE (124-478): 5.88e-56: 204: 14.29
+	Hs
		297885 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		NFASC_HUMAN (5-424): 3.3e-60: 218: 15.90
+	Mm
		645937 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		IL3RB_MOUSE (130-478): 6.85e-48: 180: 13.43
+	Mm
		193339 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INGR1_MOUSE (2-344): 2.88e-34: 137: 14.09
+	Hs
		181786 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		INGR1_HUMAN (225-542): 2.4e-30: 126: 16.19
+	Dm
		53796 ABL_DROME (14-193): 2.41e-38: 142: 14.06		A1Z921_DROME (21-430): 6.11e-35: 142: 14.45
+	Hs
		1267452 P55G_HUMAN (79-179): 8.37e-24: 99.8: 21.91		I20RA_HUMAN (18-268): 6.6e-50: 182: 20.08
+	Dm
		337644 ABL_DROME (14-193): 2.41e-38: 142: 14.06		LAR_DROME (89-527): 3.63e-26: 116: 12.78
+	Hs
		411565 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		PTPRF_HUMAN (99-540): 1.91e-25: 113: 11.31
+	Hs
		411959 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		PTPRF_HUMAN (99-540): 1.91e-25: 113: 11.31
+	Mm
		56907 FYN_MOUSE (64-194): 1.54e-37: 138: 18.44		PTPRF_MOUSE (99-540): 4.67e-25: 112: 12.20
+	Hs
		412016 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		PTPRD_HUMAN (99-452): 1.67e-23: 107: 14.68
+	Hs
		147398 SOCS3_HUMAN (39-207): 3.53e-40: 138: 27.73		IL6RB_HUMAN (29-444): 2.89e-22: 103: 10.76
+	Hs
		557632 NCK1_HUMAN (17-175): 2.39e-36: 132: 21.25		DCC_HUMAN (6-327): 2.59e-22: 103: 11.11
+	Hs
		770194 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		IL6RB_HUMAN (29-444): 2.89e-22: 103: 10.76
+	Mm
		193384 SOCS3_MOUSE (39-207): 3.5e-41: 141: 27.60		IL6RB_MOUSE (2-214): 2.33e-11: 68.8: 12.79
+	Hs
		855816 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		TITIN_HUMAN (27-125): 9.38e-10: 64.2: 12.50