Protein: EPHA8
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)

Gene: EPHA8
Organism: Homo sapiens
Interactions: 153
UniProt ID: P29322

Gene Ontology (top 5):
GO:0005003 - ephrin receptor activity
GO:0005004 - GPI-linked ephrin receptor activity
GO:0005005 - transmembrane-ephrin receptor activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

710690

EFNA5
Ephrin-A5

3

20

High-throughput

0.861

High

710712

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

20

High-throughput

0.778

High

440392

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.724

High

658851

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

20

Small-scale

0.692

High

630399

RAB3A
Ras-related protein Rab-3A

1

5

High-throughput

0.691

High

710689

EFNA4
Ephrin-A4

1

20

High-throughput

0.691

High

710693

LAMB2
Laminin subunit beta-2

1

6

High-throughput

0.691

High

710700

BTK
Tyrosine-protein kinase BTK

1

20

High-throughput

0.691

High

710708

EPHA7
Ephrin type-A receptor 7

1

19

High-throughput

0.691

High

710687

RAB7A
Ras-related protein Rab-7a

1

10

High-throughput

0.646

High

710697

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.646

High

534682

BIP
Endoplasmic reticulum chaperone BiP

2

9

High-throughput

0.628

High

562700

BMP1
Bone morphogenetic protein 1

1

3

High-throughput

0.618

High

710711

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.618

High

222023

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.618

High

296446

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

572903

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.618

High

651170

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.618

High

699597

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.618

High

710075

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.618

High

710679

CRKL
Crk-like protein

1

20

High-throughput

0.618

High

710698

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

710705

STIM1
Stromal interaction molecule 1

1

8

High-throughput

0.618

High

710721

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

20

Small-scale

0.618

High

710725

VRK2
Serine/threonine-protein kinase VRK2

1

17

High-throughput

0.618

High

710730

UNC5B
Netrin receptor UNC5B

1

18

High-throughput

0.618

High

710737

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

20

Small-scale

0.618

High

710739

STAM1
Signal transducing adapter molecule 1

1

20

High-throughput

0.618

High

710753

OSBL8
Oxysterol-binding protein-related protein 8

1

8

High-throughput

0.618

High

710764

WDR6
tRNA

1

16

High-throughput

0.618

High

710774

TBK1
Serine/threonine-protein kinase TBK1

1

17

High-throughput

0.618

High

710741

LRC59
Leucine-rich repeat-containing protein 59

1

20

High-throughput

0.578

High

710707

NUCG
Endonuclease G, mitochondrial

2

2

High-throughput

0.574

High

136301

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.553

High

610999

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

High-throughput

0.553

High

710675

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.553

High

710692

COPA
Coatomer subunit alpha

1

5

High-throughput

0.553

High

710694

SEC13
Protein SEC13 homolog

1

4

High-throughput

0.553

High

710733

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.553

High

710781

S23IP
SEC23-interacting protein

1

9

High-throughput

0.553

High

710704

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.541

High

710718

SYDM
Aspartate--tRNA ligase, mitochondrial

1

5

High-throughput

0.541

High

710777

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.536

High

690460

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.518

High

710696

PRS8
26S proteasome regulatory subunit 8

1

0

High-throughput

0.518

High

608833

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

7

High-throughput

0.500

High

710673

PEBP1
Phosphatidylethanolamine-binding protein 1

1

4

High-throughput

0.500

High

710699

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

7

High-throughput

0.500

High

710702

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.500

High

710720

MON2
Protein MON2 homolog

1

4

High-throughput

0.500

High

710749

NTPCR
Cancer-related nucleoside-triphosphatase

1

8

High-throughput

0.500

High

336186

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

6

High-throughput

0.489

High

566563

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.489

High

698406

CALX
Calnexin

1

10

High-throughput

0.489

High

710686

EMD
Emerin

1

7

High-throughput

0.489

High

710729

TRM2A
tRNA

1

2

High-throughput

0.489

High

710685

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.479

High

169449

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

192197

YKT6
Synaptobrevin homolog YKT6

1

4

High-throughput

0.479

High

332879

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

9

High-throughput

0.479

High

343902

HS74L
Heat shock 70 kDa protein 4L

1

12

High-throughput

0.479

High

612145

ARF4
ADP-ribosylation factor 4

1

14

High-throughput

0.479

High

710674

CTNB1
Catenin beta-1

1

18

High-throughput

0.479

High

710676

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

3

High-throughput

0.479

High

710680

NSF
Vesicle-fusing ATPase

1

3

High-throughput

0.479

High

710682

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

17

Small-scale

0.479

High

710691

COPB
Coatomer subunit beta

1

3

High-throughput

0.479

High

710701

CKAP4
Cytoskeleton-associated protein 4

1

17

High-throughput

0.479

High

710723

LYRIC
Protein LYRIC

1

2

High-throughput

0.479

High

710731

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

8

High-throughput

0.479

High

710736

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

710740

SYAP1
Synapse-associated protein 1

1

1

High-throughput

0.479

High

710744

ASTRA
Protein Aster-A

1

6

High-throughput

0.479

High

710750

ESYT1
Extended synaptotagmin-1

1

11

High-throughput

0.479

High

710751

NDC1
Nucleoporin NDC1

1

2

High-throughput

0.479

High

710755

OSBL2
Oxysterol-binding protein-related protein 2

1

8

High-throughput

0.479

High

710761

VEZA
Vezatin

1

1

High-throughput

0.479

High

710762

JPH1
Junctophilin-1

1

10

High-throughput

0.479

High

710769

VAPA
Vesicle-associated membrane protein-associated protein A

1

9

High-throughput

0.479

High

710775

NISCH
Nischarin

1

20

High-throughput

0.479

High

710717

ZN746
Zinc finger protein 746

1

7

High-throughput

0.464

High

710747

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

710756

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.458

High

137659

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

6

High-throughput

0.457

High

285597

BAF
Barrier-to-autointegration factor

1

6

High-throughput

0.457

High

488410

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

High-throughput

0.457

High

571376

GLU2B
Glucosidase 2 subunit beta

1

3

High-throughput

0.457

High

710677

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.457

High

710695

COPZ1
Coatomer subunit zeta-1

1

3

High-throughput

0.457

High

710722

YTHD3
YTH domain-containing family protein 3

1

9

High-throughput

0.457

High

710752

YTHD1
YTH domain-containing family protein 1

1

8

High-throughput

0.457

High

710760

XPO5
Exportin-5

1

5

High-throughput

0.457

High

710772

DJB11
DnaJ homolog subfamily B member 11

1

13

High-throughput

0.457

High

710706

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

71704

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

3

High-throughput

0.437

High

124739

AIP
AH receptor-interacting protein

1

10

High-throughput

0.437

High

139817

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

158120

COPE
Coatomer subunit epsilon

1

3

High-throughput

0.437

High

174943

SC16A
Protein transport protein Sec16A

1

9

High-throughput

0.437

High

181264

PGRC2
Membrane-associated progesterone receptor component 2

1

5

High-throughput

0.437

High

255758

USO1
General vesicular transport factor p115

1

9

High-throughput

0.437

High

258237

TRI13
E3 ubiquitin-protein ligase TRIM13

1

13

High-throughput

0.437

High

281005

TACC1
Transforming acidic coiled-coil-containing protein 1

1

13

High-throughput

0.437

High

291223

NU155
Nuclear pore complex protein Nup155

1

4

High-throughput

0.437

High

323840

SC31A
Protein transport protein Sec31A

1

6

High-throughput

0.437

High

338293

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

338429

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

417959

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

4

High-throughput

0.437

High

469007

SRPRA
Signal recognition particle receptor subunit alpha

1

5

High-throughput

0.437

High

710678

MTHR
Methylenetetrahydrofolate reductase

1

1

High-throughput

0.437

High

710681

COPD
Coatomer subunit delta

1

4

High-throughput

0.437

High

710683

LMAN1
Protein ERGIC-53

1

4

High-throughput

0.437

High

710684

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

4

High-throughput

0.437

High

710688

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

4

High-throughput

0.437

High

710703

STX5
Syntaxin-5

1

6

High-throughput

0.437

High

710709

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

710710

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.437

High

710713

RABL3
Rab-like protein 3

1

18

High-throughput

0.437

High

710714

TGO1
Transport and Golgi organization protein 1 homolog

1

9

High-throughput

0.437

High

710715

TOIP1
Torsin-1A-interacting protein 1

1

3

High-throughput

0.437

High

710716

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

2

High-throughput

0.437

High

710724

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

3

High-throughput

0.437

High

710726

LRC49
Leucine-rich repeat-containing protein 49

1

20

High-throughput

0.437

High

710727

NUDC3
NudC domain-containing protein 3

1

4

High-throughput

0.437

High

710732

EMC1
ER membrane protein complex subunit 1

1

5

High-throughput

0.437

High

710735

SCFD1
Sec1 family domain-containing protein 1

1

7

High-throughput

0.437

High

710738

TFG
Protein TFG

1

6

High-throughput

0.437

High

710745

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.437

High

710746

CK5P3
CDK5 regulatory subunit-associated protein 3

1

2

High-throughput

0.437

High

710748

CLCC1
Chloride channel CLIC-like protein 1

1

4

High-throughput

0.437

High

710754

LSG1
Large subunit GTPase 1 homolog

1

3

High-throughput

0.437

High

710757

GCP60
Golgi resident protein GCP60

1

8

High-throughput

0.437

High

710758

GORS2
Golgi reassembly-stacking protein 2

1

10

High-throughput

0.437

High

710759

WDR41
WD repeat-containing protein 41

1

5

High-throughput

0.437

High

710765

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

12

High-throughput

0.437

High

710766

AAAS
Aladin

1

8

High-throughput

0.437

High

710768

HACD3
Very-long-chain

1

3

High-throughput

0.437

High

710770

F135A
Protein FAM135A

1

6

High-throughput

0.437

High

710771

COPG2
Coatomer subunit gamma-2

1

6

High-throughput

0.437

High

710773

TRM7
tRNA

1

7

High-throughput

0.437

High

710776

MAN1
Inner nuclear membrane protein Man1

1

4

High-throughput

0.437

High

710779

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.437

High

710780

COPG1
Coatomer subunit gamma-1

1

6

High-throughput

0.437

High

627111

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

710719

ABH15
Protein ABHD15

1

0

High-throughput

0.279

Low

710728

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

489074

ALDOC
Fructose-bisphosphate aldolase C

1

0

High-throughput

0.261

Low

710734

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

710742

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.249

Low

710743

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

710763

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.249

Low

710767

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.249

Low

710778

UBIA1
UbiA prenyltransferase domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025