HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31101761
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, SH2~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 505
+	Hs
		181764 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LCK_HUMAN (1-505): 0: 569: 59.15
+	Hs
		181765 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FYN_HUMAN (1-503): 0: 562: 54.75
+	Hs
		181783 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		146668 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		YES_HUMAN (1-503): 0: 555: 53.15
+	Hs
		181770 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		YES_HUMAN (1-503): 0: 555: 53.15
+	Hs
		181771 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		146580 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		LCK_HUMAN (1-505): 0: 569: 59.15
+	Hs
		411544 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		LCK_HUMAN (1-505): 0: 569: 59.15
+	Hs
		412098 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		FYN_HUMAN (1-503): 0: 562: 54.75
+	Hs
		411545 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		FYN_HUMAN (1-503): 0: 562: 54.75
+	Hs
		146582 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		YES_HUMAN (1-503): 0: 555: 53.15
+	Hs
		411552 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		YES_HUMAN (1-503): 0: 555: 53.15
+	Hs
		411553 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		181753 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ABL1_HUMAN (54-504): 6.77e-163: 492: 41.09
+	Dm
		337688 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		SRC64_DROME (46-503): 1.57e-169: 491: 50.11
+	Dm
		337701 Q9VJA1_DROME (26-210): 3.45e-43: 154: 23.00		SRC64_DROME (46-503): 1.57e-169: 491: 50.11
+	Mm
		337630 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		ABL1_MOUSE (54-504): 4.64e-163: 493: 41.30
+	Hs
		181852 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ITK_HUMAN (29-496): 7.21e-159: 466: 36.18
+	Hs
		181816 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TEC_HUMAN (5-499): 1.09e-156: 461: 36.69
+	Hs
		147492 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		TXK_HUMAN (7-495): 2.05e-160: 467: 34.65