HitPredict

Interactor 1: GPR42 (O15529)
G-protein coupled receptor 42
Gene: GPR42

Interactor 2: CC4L (Q8NHW4)
C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)
Gene: CCL4L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Hs			1 92
+	Hs
		526565 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL4_HUMAN (1-92): 7.6e-38: 123: 96.74
+	Hs
		561733 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CL3L1_HUMAN (1-92): 5.27e-38: 123: 59.78
+	Hs
		849654 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL13_HUMAN (1-91): 6.82e-37: 121: 40.66
+	Hs
		486239 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL3_HUMAN (1-92): 5.23e-35: 116: 56.52
+	Hs
		849647 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL8_HUMAN (1-91): 2.83e-31: 106: 39.13
+	Hs
		526560 CCR1_HUMAN (16-293): 3.49e-71: 227: 22.41		CCL4_HUMAN (1-92): 7.6e-38: 123: 96.74
+	Hs
		849648 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL7_HUMAN (17-90): 1.32e-29: 102: 37.33
+	Hs
		528211 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL2_HUMAN (1-90): 1.11e-28: 100: 36.26
+	Hs
		528254 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL5_HUMAN (1-92): 1.07e-27: 97.7: 44.57
+	Hs
		486230 CCR1_HUMAN (16-293): 3.49e-71: 227: 22.41		CCL3_HUMAN (1-92): 5.23e-35: 116: 56.52
+	Hs
		849505 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL11_HUMAN (1-91): 5.09e-27: 96.2: 40.22
+	Mm
		534670 CCR5_MOUSE (16-336): 3.32e-71: 227: 21.89		CCL4_MOUSE (1-92): 1.99e-32: 109: 76.09
+	Hs
		849653 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL17_HUMAN (7-90): 3.63e-24: 88.8: 30.95
+	Hs
		180161 CCR5_HUMAN (15-336): 1.48e-78: 246: 21.83		CCL16_HUMAN (1-91): 1.53e-23: 88.1: 40.43
+	Hs
		528201 CCR1_HUMAN (16-293): 3.49e-71: 227: 22.41		CCL2_HUMAN (1-90): 1.11e-28: 100: 36.26
+	Mm
		849656 CCR5_MOUSE (16-336): 3.32e-71: 227: 21.89		CCL8_MOUSE (1-91): 8.99e-27: 95.8: 33.70
+	Mm
		222277 CCR6_MOUSE (14-305): 8.83e-76: 239: 22.15		CCL20_MOUSE (2-91): 3.73e-20: 78.8: 33.70
+	Hs
		180158 CCR1_HUMAN (16-293): 3.49e-71: 227: 22.41		CCL16_HUMAN (1-91): 1.53e-23: 88.1: 40.43
+	Hs
		849662 CCR6_HUMAN (13-334): 1.51e-77: 244: 21.07		CCL20_HUMAN (3-90): 8.4e-17: 70.4: 30.00
+	Hs
		179466 CCR9_HUMAN (16-310): 5.54e-77: 242: 23.49		CCL25_HUMAN (7-90): 5.37e-16: 69.6: 23.91