HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ITPR1 (Q14643)
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
Gene: ITPR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	12766172, 31871319
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000902 - cell morphogenesis GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0030667 - secretory granule membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 2758
+	Hs
		436303 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		ITPR1_HUMAN (1-2758): 0: 4494: 100.00
+	Hs
		950999 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ITPR1_HUMAN (1-2758): 0: 4494: 100.00
+	Hs
		894014 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ITPR1_HUMAN (1-2758): 0: 4494: 100.00
+	Hs
		545379 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		ITPR1_HUMAN (1-2758): 0: 4494: 100.00
+	Hs
		892374 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		ITPR1_HUMAN (1-2758): 0: 4494: 100.00
+	Hs
		900470 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ITPR2_HUMAN (1-2751): 0: 4139: 68.18
+	Hs
		894010 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ITPR2_HUMAN (1-2751): 0: 4139: 68.18
+	Hs
		900471 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ITPR3_HUMAN (4-2744): 0: 3845: 60.94
+	Hs
		950998 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		ITPR3_HUMAN (4-2744): 0: 3845: 60.94
+	Hs
		894011 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		ITPR3_HUMAN (4-2744): 0: 3845: 60.94
+	Hs
		545378 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		ITPR3_HUMAN (4-2744): 0: 3845: 60.94
+	Hs
		120438 RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98		ITPR3_HUMAN (4-2744): 0: 3845: 60.94