Interactor 1: CASC3 (O15234)
Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)
Gene: CASC3
Interactor 2: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.988 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32296183, 40437099, 22961380, 28514442, 33961781, 35271311, 23084401, 19478851, 16170325, 18066079, 16923391, unassigned1304, 16931718, 37020021, 19410547, 14973490, 16601204, 16209946, unassigned3799 |
| Identification Methods | two hybrid, cross-linking study, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, atpase assay, x-ray crystallography, validated two hybrid, x ray scattering, pull down and 3 others
more... |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Btz~DEAD, Btz~Helicase_C |
| Common GO terms | GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus and 8 others more... |
| Homologous interactions | 8 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
