Protein: CASC3
Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)

Gene: CASC3
Organism: Homo sapiens
Interactions: 145
UniProt ID: O15234

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

183429

IF4A3
Eukaryotic initiation factor 4A-III

19

8

Small-scale

0.988

High

183440

MGN
Protein mago nashi homolog

11

0

Small-scale

0.924

High

183541

RBM8A
RNA-binding protein 8A

8

8

Small-scale

0.745

High

183508

REN3B
Regulator of nonsense transcripts 3B

5

2

Small-scale

0.713

High

183521

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.691

High

183538

LC7L2
Putative RNA-binding protein Luc7-like 2

4

1

High-throughput

0.691

High

183460

TRA2A
Transformer-2 protein homolog alpha

3

5

High-throughput

0.667

High

183488

SNIP1
Smad nuclear-interacting protein 1

3

2

High-throughput

0.667

High

183519

LUC7L
Putative RNA-binding protein Luc7-like 1

3

1

High-throughput

0.667

High

183494

RENT1
Regulator of nonsense transcripts 1

3

3

Small-scale

0.664

High

183458

ELAV2
ELAV-like protein 2

3

7

High-throughput

0.662

High

183513

REN3A
Regulator of nonsense transcripts 3A

3

1

Small-scale

0.662

High

183514

PININ
Pinin

3

1

High-throughput

0.662

High

183423

U2AF2
Splicing factor U2AF 65 kDa subunit

2

10

High-throughput

0.628

High

183433

CDX1
Homeobox protein CDX-1

2

6

High-throughput

0.628

High

183437

CLK2
Dual specificity protein kinase CLK2

2

6

High-throughput

0.628

High

183482

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

2

High-throughput

0.628

High

183484

CELF5
CUGBP Elav-like family member 5

2

5

High-throughput

0.628

High

183422

DDX6
Probable ATP-dependent RNA helicase DDX6

1

8

High-throughput

0.618

High

183493

ESR2
Estrogen receptor beta

2

20

High-throughput

0.614

High

183470

LSM12
Protein LSM12

2

2

High-throughput

0.611

High

183504

PYM1
Partner of Y14 and mago

2

0

High-throughput

0.602

High

183520

PRDM5
PR domain zinc finger protein 5

2

0

High-throughput

0.602

High

183526

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.602

High

183414

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

6

High-throughput

0.601

High

183446

SRSF3
Serine/arginine-rich splicing factor 3

2

10

High-throughput

0.601

High

183464

RNPS1
RNA-binding protein with serine-rich domain 1

2

6

High-throughput

0.601

High

183478

NUFP2
FMR1-interacting protein NUFIP2

2

1

High-throughput

0.601

High

183505

MCRI2
MAPK regulated corepressor interacting protein 2

2

2

High-throughput

0.601

High

183518

LN28A
Protein lin-28 homolog A

2

6

High-throughput

0.601

High

183527

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.585

High

183540

YTHD2
YTH domain-containing family protein 2

2

7

High-throughput

0.584

High

183469

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

183510

REXO4
RNA exonuclease 4

2

0

High-throughput

0.576

High

183439

IF4A1
Eukaryotic initiation factor 4A-I

1

8

High-throughput

0.575

High

183534

DICER
Endoribonuclease Dicer

1

7

Small-scale

0.575

High

183409

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

183427

BMI1
Polycomb complex protein BMI-1

2

5

High-throughput

0.571

High

183448

CDK6
Cyclin-dependent kinase 6

1

1

Small-scale

0.550

High

183406

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

2

High-throughput

0.549

High

183533

PAI2B
Polyadenylate-binding protein-interacting protein 2B

2

1

High-throughput

0.549

High

183405

NBN
Nibrin

1

1

High-throughput

0.541

High

183419

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.541

High

183421

APC
Adenomatous polyposis coli protein

1

14

High-throughput

0.541

High

183428

PHB1
Prohibitin 1

1

2

High-throughput

0.541

High

183431

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

6

High-throughput

0.541

High

183457

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

2

High-throughput

0.541

High

183463

CASP8
Caspase-8

1

1

High-throughput

0.541

High

183491

TSC1
Hamartin

1

10

High-throughput

0.541

High

183402

PER1
Period circadian protein homolog 1

1

1

High-throughput

0.536

High

183403

KIF1C
Kinesin-like protein KIF1C

1

5

High-throughput

0.536

High

183404

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

4

High-throughput

0.536

High

183417

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

2

High-throughput

0.536

High

183430

MNDA
Myeloid cell nuclear differentiation antigen

1

5

High-throughput

0.536

High

183432

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

183438

CLK3
Dual specificity protein kinase CLK3

1

6

High-throughput

0.536

High

183453

SRSF1
Serine/arginine-rich splicing factor 1

1

11

High-throughput

0.536

High

183456

ILF2
Interleukin enhancer-binding factor 2

1

1

High-throughput

0.536

High

183459

SRSF6
Serine/arginine-rich splicing factor 6

1

9

High-throughput

0.536

High

183461

MAP7
Ensconsin

1

17

High-throughput

0.536

High

183465

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

8

High-throughput

0.536

High

183466

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

183467

SRSF7
Serine/arginine-rich splicing factor 7

1

10

High-throughput

0.536

High

183468

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

10

High-throughput

0.536

High

183473

L2GL2
LLGL scribble cell polarity complex component 2

1

3

High-throughput

0.536

High

183480

THOC4
THO complex subunit 4

1

4

High-throughput

0.536

High

183481

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

183485

KDM1B
Lysine-specific histone demethylase 2

1

6

High-throughput

0.536

High

183490

PSPC1
Paraspeckle component 1

1

9

High-throughput

0.536

High

183492

LAR4B
La-related protein 4B

1

2

High-throughput

0.536

High

183496

MED12
Mediator of RNA polymerase II transcription subunit 12

1

18

High-throughput

0.536

High

183499

PABP5
Polyadenylate-binding protein 5

1

8

High-throughput

0.536

High

183529

PUF60
Poly(U)-binding-splicing factor PUF60

1

10

High-throughput

0.536

High

183532

RALY
RNA-binding protein Raly

1

3

High-throughput

0.536

High

183536

YBOX2
Y-box-binding protein 2

1

6

High-throughput

0.536

High

183539

CCDC9
Coiled-coil domain-containing protein 9

1

1

High-throughput

0.536

High

183472

Q6ICH2
single-stranded DNA cytosine deaminase

2

2

High-throughput

0.533

High

183425

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

High-throughput

0.518

High

134480

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.513

High

183401

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

183413

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

183436

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

183442

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

183511

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

0

High-throughput

0.513

High

183522

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.513

High

183524

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

183525

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.513

High

183531

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

183420

FGFR4
Fibroblast growth factor receptor 4

1

16

High-throughput

0.494

High

183503

RTP3
Receptor-transporting protein 3

1

1

High-throughput

0.489

High

183443

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.481

High

47930

RBM47
RNA-binding protein 47

1

7

High-throughput

0.479

High

172271

XPO1
Exportin-1

1

8

High-throughput

0.479

High

183408

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.479

High

183410

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

183411

MYCN
N-myc proto-oncogene protein

1

17

High-throughput

0.479

High

183412

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

183415

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

183416

PABP1
Polyadenylate-binding protein 1

1

8

High-throughput

0.479

High

183418

YBOX3
Y-box-binding protein 3

1

6

High-throughput

0.479

High

183424

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

9

High-throughput

0.479

High

183426

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

183434

PRC2A
Protein PRRC2A

1

11

High-throughput

0.479

High

183435

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

183441

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

183447

RBM3
RNA-binding protein 3

1

5

Small-scale

0.479

High

183449

EWS
RNA-binding protein EWS

1

8

High-throughput

0.479

High

183450

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

183451

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

183452

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.479

High

183454

EP300
Histone acetyltransferase p300

1

15

High-throughput

0.479

High

183455

GRSF1
G-rich sequence factor 1

1

6

High-throughput

0.479

High

183462

RBM39
RNA-binding protein 39

1

9

High-throughput

0.479

High

183474

MEX3B
RNA-binding protein MEX3B

1

2

High-throughput

0.479

High

183495

DAZL
Deleted in azoospermia-like

1

9

High-throughput

0.479

High

183497

FUBP1
Far upstream element-binding protein 1

1

4

High-throughput

0.479

High

183501

ATX2
Ataxin-2

1

12

High-throughput

0.479

High

183502

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

1

High-throughput

0.479

High

183506

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

183507

YTHD1
YTH domain-containing family protein 1

1

7

High-throughput

0.479

High

183517

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

183528

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

183530

XPO7
Exportin-7

1

7

High-throughput

0.479

High

183535

R3HD2
R3H domain-containing protein 2

1

8

High-throughput

0.479

High

183537

TR150
Thyroid hormone receptor-associated protein 3

1

9

Small-scale

0.479

High

183487

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

183500

PRR11
Proline-rich protein 11

1

0

High-throughput

0.458

High

183509

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

183407

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

Small-scale

0.445

High

183444

YBOX1
Y-box-binding protein 1

1

6

High-throughput

0.445

High

183471

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.445

High

183486

FA98A
Protein FAM98A

1

1

High-throughput

0.445

High

183498

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

2

High-throughput

0.445

High

183512

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

7

High-throughput

0.445

High

183515

E41L1
Band 4.1-like protein 1

1

6

High-throughput

0.445

High

183475

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

183479

PAQR2
Adiponectin receptor protein 2

1

1

Small-scale

0.437

High

183516

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

183523

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

183445

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.426

High

73352

B2CML4
single-stranded DNA cytosine deaminase

1

2

High-throughput

0.407

High

183476

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

183489

THAP3
THAP domain-containing protein 3

2

0

High-throughput

0.313

High

183477

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.279

Low

183483

OTU6B
Deubiquitinase OTUD6B

1

0

Small-scale

0.269

Low


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Last updated: 11Aug2025