Interactor 1: SHIP2 (O15357)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
Gene: INPPL1

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 36976175, 22244754
Identification Methods proximity labelling technology, isothermal titration calorimetry, nuclear magnetic resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SAM_1, SAM_1~SAM_1, SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0007155 - cell adhesion
GO:0030027 - lamellipodium
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1258
Hs

1 976
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Service provided by Combinatics, Japan

Last updated: 11Aug2025