HitPredict

Interactor 1: SRBS2 (O35413)
Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Neural ArgBP2) (nArgBP2) (Sorbin)
Gene: Sorbs2

Interactor 2: SH3G1 (O35964)
Endophilin-A2 (Endophilin-2) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) (SH3p8)
Gene: Sh3gl1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15659545
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH3_1~SH3_1
Common GO terms	GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1196 Rn			1 368
+	Hs
		298986 SRBS2_HUMAN (101-1196): 0: 671: 87.02		SH3R1_HUMAN (305-361): 5.26e-12: 69.1: 45.90
+	Hs
		298942 SRBS2_HUMAN (101-1196): 0: 671: 87.02		SRBS2_HUMAN (311-364): 1.6e-10: 64.8: 41.07
+	Hs
		1307421 ITSN2_HUMAN (53-1101): 1.05e-43: 176: 11.66		SH3G1_HUMAN (1-368): 4.63e-86: 266: 92.94
+	Hs
		548634 VAV_HUMAN (491-1195): 2.21e-56: 213: 11.90		PLCG1_HUMAN (43-362): 1.14e-32: 131: 12.76
+	Hs
		548630 VAV_HUMAN (491-1195): 2.21e-56: 213: 11.90		PLCG2_HUMAN (43-363): 2.94e-32: 130: 13.07
+	Hs
		548677 VAV_HUMAN (491-1195): 2.21e-56: 213: 11.90		GRB2_HUMAN (311-367): 1.7e-12: 67.9: 39.66
+	Hs
		924777 Q96D37_HUMAN (491-1195): 1.02e-56: 213: 11.90		GRB2_HUMAN (311-367): 1.7e-12: 67.9: 39.66
+	Mm
		654982 VAV_MOUSE (491-1195): 1.16e-52: 202: 12.17		GRB2_MOUSE (311-367): 1.7e-12: 67.9: 39.66
+	Hs
		855781 VAV2_HUMAN (460-1195): 9.66e-48: 187: 12.42		GRB2_HUMAN (311-367): 1.7e-12: 67.9: 39.66
+	Mm
		434800 SPTA1_MOUSE (184-1032): 5.49e-44: 177: 12.45		SRBS2_MOUSE (311-368): 5.13e-11: 66.4: 37.50
+	Mm
		1141129 VAV2_MOUSE (460-1195): 4.26e-44: 175: 12.63		GRB2_MOUSE (311-367): 1.7e-12: 67.9: 39.66
+	Rn
		192738 SPTN1_RAT (178-1050): 3.24e-43: 175: 10.48		SRBS2_RAT (311-368): 3.7e-11: 66.8: 37.50
+	Hs
		1078919 ITSN2_HUMAN (53-1101): 1.05e-43: 176: 11.66		ITSN1_HUMAN (199-366): 7.13e-10: 62.7: 13.30
+	Xl
		60960 GRB2A_XENLA (820-1019): 2.46e-19: 90.2: 18.45		A5LHG3_XENLA (43-368): 7.69e-38: 146: 13.70
+	Hs
		536574 GRB2_HUMAN (820-1019): 2.27e-19: 90.2: 18.50		HCLS1_HUMAN (9-364): 8.18e-36: 138: 14.18
+	Mm
		1141132 GRB2_MOUSE (820-1019): 1.37e-19: 90.6: 18.50		PLCG1_MOUSE (43-362): 3.34e-33: 133: 13.06
+	Rn
		499159 GRB2_RAT (820-1019): 2.27e-19: 90.2: 18.50		PLCG1_RAT (43-362): 2.31e-33: 133: 12.76
+	Hs
		580972 GRB2_HUMAN (820-1019): 2.27e-19: 90.2: 18.50		PLCG1_HUMAN (43-362): 1.14e-32: 131: 12.76
+	Hs
		562638 GRB2_HUMAN (820-1019): 2.27e-19: 90.2: 18.50		PLCG2_HUMAN (43-363): 2.94e-32: 130: 13.07
+	Hs
		208967 NCK2_HUMAN (921-1133): 5.55e-28: 119: 19.56		SRBS2_HUMAN (311-364): 1.6e-10: 64.8: 41.07