Protein: ARPC5
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)

Gene: ARPC5
Organism: Homo sapiens
Interactions: 98
UniProt ID: O15511

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

192701

ARPC4
Actin-related protein 2/3 complex subunit 4

15

5

Small-scale

0.981

High

179094

ARC1B
Actin-related protein 2/3 complex subunit 1B

9

5

Small-scale

0.974

High

192704

ARP2
Actin-related protein 2

9

8

Small-scale

0.971

High

192737

ARC1A
Actin-related protein 2/3 complex subunit 1A

6

5

Small-scale

0.950

High

192703

ARP3
Actin-related protein 3

6

9

Small-scale

0.947

High

192753

ARP3B
Actin-related protein 3B

5

9

High-throughput

0.932

High

179423

ARPC3
Actin-related protein 2/3 complex subunit 3

7

3

Small-scale

0.750

High

179271

ARPC2
Actin-related protein 2/3 complex subunit 2

5

3

Small-scale

0.714

High

192707

ACTG
Actin, cytoplasmic 2

1

3

High-throughput

0.691

High

192702

CDC42
Cell division control protein 42 homolog

2

1

High-throughput

0.628

High

192728

VP13C
Intermembrane lipid transfer protein VPS13C

2

1

High-throughput

0.628

High

192740

VP13A
Intermembrane lipid transfer protein VPS13A

2

1

High-throughput

0.628

High

192708

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.618

High

192725

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.618

High

192748

ANLN
Anillin

2

1

High-throughput

0.611

High

192670

RAD21
Double-strand-break repair protein rad21 homolog

2

0

High-throughput

0.602

High

192674

HUS1
Checkpoint protein HUS1

2

0

High-throughput

0.602

High

192683

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

0

High-throughput

0.602

High

192713

TROP
Trophinin

2

0

High-throughput

0.602

High

192716

DPOA2
DNA polymerase alpha subunit B

2

0

High-throughput

0.602

High

192721

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

2

0

High-throughput

0.602

High

192744

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

0

High-throughput

0.602

High

192745

KPCD2
Serine/threonine-protein kinase D2

2

0

High-throughput

0.602

High

192752

MKS1
Tectonic-like complex member MKS1

2

0

High-throughput

0.602

High

192675

SH3L1
Adapter SH3BGRL

2

1

High-throughput

0.571

High

192680

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

192689

RASA1
Ras GTPase-activating protein 1

2

2

High-throughput

0.571

High

192668

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

0

High-throughput

0.547

High

192678

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.541

High

192669

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.536

High

192691

MYH11
Myosin-11

1

2

High-throughput

0.536

High

192693

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

192694

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

192697

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

192698

DAPK1
Death-associated protein kinase 1

1

1

High-throughput

0.536

High

192712

CALD1
Caldesmon

1

8

High-throughput

0.536

High

192717

SRC8
Src substrate cortactin

1

3

High-throughput

0.536

High

192720

DREB
Drebrin

1

3

High-throughput

0.536

High

192731

SYNPO
Synaptopodin

1

1

High-throughput

0.536

High

192749

MYO5C
Unconventional myosin-Vc

1

2

High-throughput

0.536

High

192754

STK26
Serine/threonine-protein kinase 26

1

2

High-throughput

0.536

High

192758

DBNL
Drebrin-like protein

1

5

High-throughput

0.536

High

192759

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

High-throughput

0.536

High

192696

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.513

High

187827

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

0

High-throughput

0.513

High

192676

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

192709

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

192710

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.513

High

192719

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

192730

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

0

High-throughput

0.513

High

192743

GGACT
Gamma-glutamylaminecyclotransferase

1

0

High-throughput

0.513

High

192681

GCR
Glucocorticoid receptor

1

4

Small-scale

0.481

High

192671

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

192672

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

192677

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

192679

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

192686

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.479

High

192688

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

192692

PPARG
Peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.479

High

192695

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

192700

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

192722

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

Small-scale

0.479

High

192729

TAXB1
Tax1-binding protein 1

1

5

High-throughput

0.479

High

192732

BICD2
Protein bicaudal D homolog 2

1

5

High-throughput

0.479

High

192736

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

192747

SIK2
Serine/threonine-protein kinase SIK2

1

1

Small-scale

0.479

High

192755

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

136028

PLK4
Serine/threonine-protein kinase PLK4

1

0

Small-scale

0.458

High

156710

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

192682

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

192687

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

192690

IF4B
Eukaryotic translation initiation factor 4B

1

0

Small-scale

0.458

High

192705

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

192718

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.458

High

192724

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

192727

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

192733

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

192735

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

192738

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

192742

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

0

High-throughput

0.458

High

192756

SAE2
SUMO-activating enzyme subunit 2

1

0

High-throughput

0.458

High

192757

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

192684

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

192685

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

192711

RHOG
Rho-related GTP-binding protein RhoG

1

1

Small-scale

0.445

High

192714

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

192734

CHUR
Protein Churchill

1

1

High-throughput

0.437

High

192699

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

192706

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

192715

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

192726

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

192741

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

0

High-throughput

0.426

High

192673

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

192723

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.279

Low

192739

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

192750

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

192751

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.279

Low

192746

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025