Protein: ARC1A
Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)

Gene: ARC1A, ARPC1A
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q92747

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005885 - Arp2/3 protein complex
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

958322

ARP2
Actin-related protein 2

9

15

Small-scale

0.975

High

958167

ARP3
Actin-related protein 3

8

16

Small-scale

0.969

High

192737

ARPC5
Actin-related protein 2/3 complex subunit 5

6

5

Small-scale

0.950

High

1367888

ARP3B
Actin-related protein 3B

6

16

High-throughput

0.943

High

1367875

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

4

5

Small-scale

0.903

High

948457

ARPC4
Actin-related protein 2/3 complex subunit 4

4

5

Small-scale

0.900

High

179386

ARPC2
Actin-related protein 2/3 complex subunit 2

11

4

Small-scale

0.758

High

179548

ARPC3
Actin-related protein 2/3 complex subunit 3

7

5

Small-scale

0.749

High

783165

ARL3
ADP-ribosylation factor-like protein 3

1

11

High-throughput

0.691

High

953001

ACTB
Actin, cytoplasmic 1

1

11

High-throughput

0.691

High

1367871

ARL8A
ADP-ribosylation factor-like protein 8A

1

6

High-throughput

0.691

High

1367884

ARL8B
ADP-ribosylation factor-like protein 8B

1

8

High-throughput

0.691

High

1367894

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

9

High-throughput

0.691

High

1136045

CND2
Condensin complex subunit 2

3

1

High-throughput

0.667

High

1367893

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.656

High

1042901

ERCC6
DNA excision repair protein ERCC-6

1

13

High-throughput

0.647

High

1137250

CND1
Condensin complex subunit 1

3

0

High-throughput

0.638

High

1367874

CND3
Condensin complex subunit 3

3

0

High-throughput

0.638

High

179236

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

18

High-throughput

0.618

High

930003

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

12

High-throughput

0.618

High

1155611

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.618

High

1367877

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.618

High

1367882

ANLN
Anillin

1

5

High-throughput

0.618

High

942791

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

7

High-throughput

0.611

High

867317

CAPZB
F-actin-capping protein subunit beta

2

7

High-throughput

0.601

High

1160711

DREB
Drebrin

2

6

High-throughput

0.601

High

1367892

DBNL
Drebrin-like protein

2

10

High-throughput

0.601

High

1107984

SQSTM
Sequestosome-1

2

1

High-throughput

0.584

High

1234888

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.575

High

1367883

DDX28
Probable ATP-dependent RNA helicase DDX28

1

12

High-throughput

0.575

High

1367895

COR2B
Coronin-2B

1

19

High-throughput

0.575

High

277943

SH3L1
Adapter SH3BGRL

2

1

High-throughput

0.571

High

1367876

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

1254893

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

564151

CFTR
Cystic fibrosis transmembrane conductance regulator

2

5

High-throughput

0.552

High

224769

ACTN4
Alpha-actinin-4

1

3

High-throughput

0.536

High

347850

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.536

High

375798

RASK
GTPase KRas

1

8

High-throughput

0.536

High

730117

1433B
14-3-3 protein beta/alpha

1

11

High-throughput

0.536

High

920487

DAPK1
Death-associated protein kinase 1

1

4

High-throughput

0.536

High

1052074

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1100935

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.536

High

1124679

SRC8
Src substrate cortactin

1

10

High-throughput

0.536

High

1367889

STK26
Serine/threonine-protein kinase 26

1

9

High-throughput

0.536

High

482162

RET1
Retinol-binding protein 1

1

0

High-throughput

0.513

High

1331333

AL14E
ARL14 effector protein

1

0

High-throughput

0.513

High

1367879

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.513

High

1106634

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.506

High

297239

PRAF3
PRA1 family protein 3

1

2

High-throughput

0.489

High

1329695

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

1

High-throughput

0.489

High

136117

PLK4
Serine/threonine-protein kinase PLK4

1

7

Small-scale

0.479

High

143150

NFIB
Nuclear factor 1 B-type

1

16

High-throughput

0.479

High

173161

XPO1
Exportin-1

1

13

High-throughput

0.479

High

242470

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

248021

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

260241

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

352506

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.479

High

372731

MYC
Myc proto-oncogene protein

1

17

High-throughput

0.479

High

474164

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

515722

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.479

High

520242

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

578523

BRAF
Serine/threonine-protein kinase B-raf

1

6

High-throughput

0.479

High

589308

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

696100

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

768795

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

831161

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

872593

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

1107072

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1135020

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1290917

TAXB1
Tax1-binding protein 1

1

12

High-throughput

0.479

High

1360788

ASB11
Ankyrin repeat and SOCS box protein 11

1

9

High-throughput

0.479

High

1366931

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1367878

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

1367881

SIK2
Serine/threonine-protein kinase SIK2

1

3

Small-scale

0.479

High

1367885

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

High-throughput

0.479

High

1367891

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

646905

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

255147

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

515648

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.445

High

516361

CALM1
Calmodulin-1

1

2

High-throughput

0.445

High

516564

CALM3
Calmodulin-3

1

2

High-throughput

0.445

High

530158

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.445

High

934941

TERA
Transitional endoplasmic reticulum ATPase

1

10

High-throughput

0.445

High

955888

GMFB
Glia maturation factor beta

1

4

High-throughput

0.445

High

987813

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.445

High

1015650

RHOG
Rho-related GTP-binding protein RhoG

1

3

Small-scale

0.445

High

1103298

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.445

High

1178286

CL16A
Protein CLEC16A

1

1

High-throughput

0.445

High

1209465

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

1361628

SSH1
Protein phosphatase Slingshot homolog 1

1

1

High-throughput

0.445

High

1367872

PRPK
EKC/KEOPS complex subunit TP53RK

1

3

High-throughput

0.445

High

1367873

PKP2
Plakophilin-2

1

11

High-throughput

0.445

High

1367880

TOLIP
Toll-interacting protein

1

1

High-throughput

0.445

High

1367890

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

12

High-throughput

0.445

High

106382

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

418323

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

1356688

CHUR
Protein Churchill

1

1

High-throughput

0.437

High

1360907

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

1367887

HACD3
Very-long-chain

1

2

High-throughput

0.437

High

369194

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

1367886

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.426

High

261237

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

330257

VENTX
Homeobox protein VENTX

1

10

High-throughput

0.407

High

1214164

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

1367870

RN166
E3 ubiquitin-protein ligase RNF166

1

4

High-throughput

0.407

High


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Last updated: 11Aug2025