Protein: ARP5L
Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)

Gene: ARP5L, ARPC5L
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q9BPX5

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005885 - Arp2/3 protein complex
GO:0005925 - focal adhesion
GO:0016477 - cell migration
GO:0030833 - regulation of actin filament polymerization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

948463

ARPC4
Actin-related protein 2/3 complex subunit 4

18

5

Small-scale

0.986

High

179242

ARC1B
Actin-related protein 2/3 complex subunit 1B

6

5

Small-scale

0.947

High

958338

ARP2
Actin-related protein 2

6

8

Small-scale

0.944

High

958181

ARP3
Actin-related protein 3

5

9

Small-scale

0.924

High

1367875

ARC1A
Actin-related protein 2/3 complex subunit 1A

4

5

Small-scale

0.903

High

1409696

ARP3B
Actin-related protein 3B

4

9

High-throughput

0.900

High

179558

ARPC3
Actin-related protein 2/3 complex subunit 3

6

3

Small-scale

0.735

High

953059

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.691

High

993312

ACTG
Actin, cytoplasmic 2

1

3

High-throughput

0.691

High

179390

ARPC2
Actin-related protein 2/3 complex subunit 2

3

3

Small-scale

0.660

High

564285

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.650

High

332179

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

3

0

High-throughput

0.626

High

866802

CAZA2
F-actin-capping protein subunit alpha-2

2

2

High-throughput

0.601

High

867381

CAPZB
F-actin-capping protein subunit beta

2

3

High-throughput

0.601

High

1160737

DREB
Drebrin

2

3

High-throughput

0.601

High

1409690

ANLN
Anillin

3

1

High-throughput

0.599

High

1409702

COR2B
Coronin-2B

1

1

High-throughput

0.575

High

277949

SH3L1
Adapter SH3BGRL

2

1

High-throughput

0.571

High

396809

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

1096488

PAK1
Serine/threonine-protein kinase PAK 1

2

2

High-throughput

0.571

High

224785

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.536

High

637702

FLNA
Filamin-A

1

2

High-throughput

0.536

High

732686

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

772983

MYH9
Myosin-9

1

2

High-throughput

0.536

High

776852

MYH11
Myosin-11

1

2

High-throughput

0.536

High

862961

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.536

High

920497

DAPK1
Death-associated protein kinase 1

1

1

High-throughput

0.536

High

1124699

SRC8
Src substrate cortactin

1

3

High-throughput

0.536

High

1325444

SYNPO
Synaptopodin

1

1

High-throughput

0.536

High

1365582

MY18A
Unconventional myosin-XVIIIa

1

3

High-throughput

0.536

High

1392659

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.536

High

1409691

MYO5C
Unconventional myosin-Vc

1

2

High-throughput

0.536

High

1409697

STK26
Serine/threonine-protein kinase 26

1

2

High-throughput

0.536

High

1409700

DBNL
Drebrin-like protein

1

5

High-throughput

0.536

High

1409701

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

High-throughput

0.536

High

668010

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.513

High

902291

RB27A
Ras-related protein Rab-27A

1

0

High-throughput

0.513

High

1409692

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

1409693

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.513

High

1409699

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.513

High

1409686

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.494

High

1250908

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

1

0

High-throughput

0.493

High

1052093

CALD1
Caldesmon

1

8

High-throughput

0.489

High

248065

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

607051

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

872677

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

1115958

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

1409688

SIK2
Serine/threonine-protein kinase SIK2

1

1

Small-scale

0.479

High

1409698

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

173276

XPO1
Exportin-1

1

0

High-throughput

0.458

High

178373

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

192742

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.458

High

294239

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

535459

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

630016

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

646925

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

1140754

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1409689

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

255188

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

516578

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

530290

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

942842

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

1103345

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

372972

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

897954

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.437

High

1356690

CHUR
Protein Churchill

1

1

High-throughput

0.437

High

1360810

ASB11
Ankyrin repeat and SOCS box protein 11

1

2

High-throughput

0.437

High

1367118

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

1409685

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

1409694

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

1409695

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.426

High

1401798

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.279

Low

1155704

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1409687

RNF38
E3 ubiquitin-protein ligase RNF38

1

0

Small-scale

0.249

Low

261261

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

765833

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.232

Low

955895

GMFB
Glia maturation factor beta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025