Protein: ARC1B
Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)

Gene: ARC1B, ARPC1B
Organism: Homo sapiens
Interactions: 189
UniProt ID: O15143

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005885 - Arp2/3 protein complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

179177

ARP2
Actin-related protein 2

12

15

Small-scale

0.980

High

179094

ARPC5
Actin-related protein 2/3 complex subunit 5

9

5

Small-scale

0.974

High

179176

ARP3
Actin-related protein 3

10

16

Small-scale

0.974

High

179174

ARPC4
Actin-related protein 2/3 complex subunit 4

8

5

Small-scale

0.970

High

179258

ARP3B
Actin-related protein 3B

7

16

High-throughput

0.962

High

179242

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

6

5

Small-scale

0.947

High

179253

ASH1L
Histone-lysine N-methyltransferase ASH1L

2

11

High-throughput

0.776

High

179092

ARPC2
Actin-related protein 2/3 complex subunit 2

15

4

Small-scale

0.763

High

179251

ANLN
Anillin

2

5

High-throughput

0.754

High

179093

ARPC3
Actin-related protein 2/3 complex subunit 3

8

5

Small-scale

0.751

High

179141

RASA1
Ras GTPase-activating protein 1

2

4

High-throughput

0.737

High

179268

COR2B
Coronin-2B

2

19

Small-scale

0.737

High

179175

ACTB
Actin, cytoplasmic 1

1

11

High-throughput

0.691

High

179188

ACTG
Actin, cytoplasmic 2

1

11

High-throughput

0.691

High

179259

POGK
Pogo transposable element with KRAB domain

3

2

High-throughput

0.667

High

179091

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

17

High-throughput

0.665

High

179132

CFTR
Cystic fibrosis transmembrane conductance regulator

3

5

High-throughput

0.650

High

179230

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

3

0

High-throughput

0.638

High

156701

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

179123

RS17
Small ribosomal subunit protein eS17

1

4

Small-scale

0.618

High

179170

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

12

High-throughput

0.618

High

179178

RL27
Large ribosomal subunit protein eL27

1

1

Small-scale

0.618

High

179186

RL30
Large ribosomal subunit protein eL30

1

3

Small-scale

0.618

High

179211

EZH2
Histone-lysine N-methyltransferase EZH2

1

16

High-throughput

0.618

High

179223

H2AV
Histone H2A.V

1

9

Small-scale

0.618

High

179236

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

18

High-throughput

0.618

High

179238

FBXW7
F-box/WD repeat-containing protein 7

1

18

Small-scale

0.618

High

179245

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.618

High

179250

MYO10
Unconventional myosin-X

1

6

Small-scale

0.618

High

179266

COR1C
Coronin-1C

1

19

Small-scale

0.618

High

133605

WASL
Actin nucleation-promoting factor WASL

2

12

Small-scale

0.611

High

179096

ACTN4
Alpha-actinin-4

2

3

Small-scale

0.611

High

179142

FLNA
Filamin-A

2

15

Small-scale

0.611

High

179213

DREB
Drebrin

2

6

Small-scale

0.611

High

179158

WASP
Actin nucleation-promoting factor WAS

2

10

Small-scale

0.595

High

179110

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

179156

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

2

3

Small-scale

0.584

High

169820

AURKA
Aurora kinase A

1

7

Small-scale

0.578

High

179219

PKHA7
Pleckstrin homology domain-containing family A member 7

1

18

High-throughput

0.575

High

179100

SH3L1
Adapter SH3BGRL

2

1

High-throughput

0.571

High

179135

H12
Histone H1.2

2

8

Small-scale

0.571

High

179217

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

Small-scale

0.571

High

179226

ARHGP
Rho guanine nucleotide exchange factor 25

2

5

High-throughput

0.571

High

179198

PAK1
Serine/threonine-protein kinase PAK 1

1

7

Small-scale

0.561

High

179222

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

179190

SRPK2
SRSF protein kinase 2

1

17

High-throughput

0.550

High

123509

MYO1C
Unconventional myosin-Ic

1

10

High-throughput

0.536

High

179111

RASK
GTPase KRas

1

8

High-throughput

0.536

High

179112

ESR1
Estrogen receptor

1

20

High-throughput

0.536

High

179144

CDK2
Cyclin-dependent kinase 2

1

6

High-throughput

0.536

High

179153

MYH9
Myosin-9

1

3

High-throughput

0.536

High

179159

CRK
Adapter molecule crk

1

5

High-throughput

0.536

High

179162

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

179163

CAPZB
F-actin-capping protein subunit beta

1

7

High-throughput

0.536

High

179169

DAPK1
Death-associated protein kinase 1

1

4

High-throughput

0.536

High

179172

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

9

High-throughput

0.536

High

179192

CALD1
Caldesmon

1

20

High-throughput

0.536

High

179197

TWF1
Twinfilin-1

1

3

High-throughput

0.536

High

179205

SRC8
Src substrate cortactin

1

10

High-throughput

0.536

High

179225

PIM3
Serine/threonine-protein kinase pim-3

1

6

High-throughput

0.536

High

179227

SYNPO
Synaptopodin

1

12

High-throughput

0.536

High

179241

MYO19
Unconventional myosin-XIX

1

5

High-throughput

0.536

High

179252

MYO5C
Unconventional myosin-Vc

1

4

High-throughput

0.536

High

179260

STK26
Serine/threonine-protein kinase 26

1

9

High-throughput

0.536

High

179263

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.536

High

179095

ADCY6
Adenylate cyclase type 6

1

0

Small-scale

0.517

High

179204

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

179114

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

179164

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.493

High

179101

PRAF3
PRA1 family protein 3

1

2

High-throughput

0.489

High

179228

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

1

High-throughput

0.489

High

179234

MY18A
Unconventional myosin-XVIIIa

1

5

High-throughput

0.489

High

134969

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

12

High-throughput

0.479

High

136026

PLK4
Serine/threonine-protein kinase PLK4

1

8

Small-scale

0.479

High

172264

XPO1
Exportin-1

1

14

High-throughput

0.479

High

178099

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

179097

SPOP
Speckle-type POZ protein

1

4

High-throughput

0.479

High

179098

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.479

High

179099

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

179102

SRBS2
Sorbin and SH3 domain-containing protein 2

1

11

Small-scale

0.479

High

179103

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

High-throughput

0.479

High

179104

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

Small-scale

0.479

High

179105

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

10

High-throughput

0.479

High

179107

LDHA
L-lactate dehydrogenase A chain

1

1

Small-scale

0.479

High

179108

A1AT
Alpha-1-antitrypsin

1

6

Small-scale

0.479

High

179109

AACT
Alpha-1-antichymotrypsin

1

5

Small-scale

0.479

High

179115

ADT2
ADP/ATP translocase 2

1

4

Small-scale

0.479

High

179116

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

5

Small-scale

0.479

High

179117

RLA2
Large ribosomal subunit protein P2

1

4

Small-scale

0.479

High

179118

TETN
Tetranectin

1

2

Small-scale

0.479

High

179119

K1C18
Keratin, type I cytoskeletal 18

1

6

Small-scale

0.479

High

179120

K2C8
Keratin, type II cytoskeletal 8

1

4

Small-scale

0.479

High

179122

TPM2
Tropomyosin beta chain

1

1

Small-scale

0.479

High

179124

ANXA5
Annexin A5

1

1

Small-scale

0.479

High

179125

LEG1
Galectin-1

1

4

Small-scale

0.479

High

179126

PARP1
Poly [ADP-ribose] polymerase 1

1

7

Small-scale

0.479

High

179129

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.479

High

179130

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

Small-scale

0.479

High

179131

KCRB
Creatine kinase B-type

1

1

Small-scale

0.479

High

179133

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

179134

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.479

High

179136

YBOX3
Y-box-binding protein 3

1

3

Small-scale

0.479

High

179137

NUCL
Nucleolin

1

5

Small-scale

0.479

High

179139

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

179140

PSB1
Proteasome subunit beta type-1

1

1

Small-scale

0.479

High

179143

TBG1
Tubulin gamma-1 chain

1

20

Small-scale

0.479

High

179145

U2AF2
Splicing factor U2AF 65 kDa subunit

1

12

High-throughput

0.479

High

179146

RL13
Large ribosomal subunit protein eL13

1

2

Small-scale

0.479

High

179147

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

179148

MAP4
Microtubule-associated protein 4

1

17

Small-scale

0.479

High

179149

TEAD1
Transcriptional enhancer factor TEF-1

1

1

Small-scale

0.479

High

179150

RL12
Large ribosomal subunit protein uL11

1

3

Small-scale

0.479

High

179154

MYH10
Myosin-10

1

3

Small-scale

0.479

High

179155

SOX3
Transcription factor SOX-3

1

20

Small-scale

0.479

High

179157

RL35
Large ribosomal subunit protein uL29

1

1

Small-scale

0.479

High

179160

RL21
Large ribosomal subunit protein eL21

1

1

Small-scale

0.479

High

179161

RL28
Large ribosomal subunit protein eL28

1

1

Small-scale

0.479

High

179167

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

18

Small-scale

0.479

High

179168

HMGA2
High mobility group protein HMGI-C

1

1

Small-scale

0.479

High

179173

RAB25
Ras-related protein Rab-25

1

5

High-throughput

0.479

High

179179

RS7
Small ribosomal subunit protein eS7

1

4

Small-scale

0.479

High

179180

RS8
Small ribosomal subunit protein eS8

1

5

Small-scale

0.479

High

179181

RS23
Small ribosomal subunit protein uS12

1

2

Small-scale

0.479

High

179182

RS29
Small ribosomal subunit protein uS14

1

1

Small-scale

0.479

High

179183

RS11
Small ribosomal subunit protein uS17

1

4

Small-scale

0.479

High

179184

RL23A
Large ribosomal subunit protein uL23

1

4

Small-scale

0.479

High

179185

RS15
Small ribosomal subunit protein uS19

1

3

Small-scale

0.479

High

179187

RL31
Large ribosomal subunit protein eL31

1

2

Small-scale

0.479

High

179189

YBOX1
Y-box-binding protein 1

1

3

Small-scale

0.479

High

179191

RL24
Large ribosomal subunit protein eL24

1

2

Small-scale

0.479

High

179193

RL18
Large ribosomal subunit protein eL18

1

3

Small-scale

0.479

High

179194

ZO1
Tight junction protein 1

1

4

Small-scale

0.479

High

179195

SRSF1
Serine/arginine-rich splicing factor 1

1

11

Small-scale

0.479

High

179199

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.479

High

179200

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

179202

SMAD4
Mothers against decapentaplegic homolog 4

1

5

High-throughput

0.479

High

179203

PKP1
Plakophilin-1

1

9

Small-scale

0.479

High

179206

NC2A
Dr1-associated corepressor

1

2

Small-scale

0.479

High

179207

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

17

High-throughput

0.479

High

179208

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

179209

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

179210

ELAV1
ELAV-like protein 1

1

3

Small-scale

0.479

High

179214

IF16
Gamma-interferon-inducible protein 16

1

2

Small-scale

0.479

High

179215

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

12

High-throughput

0.479

High

179224

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

179229

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.479

High

179232

ASB11
Ankyrin repeat and SOCS box protein 11

1

9

High-throughput

0.479

High

179233

H1X
Histone H1.10

1

2

Small-scale

0.479

High

179235

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

179237

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

179244

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.479

High

179246

SIK2
Serine/threonine-protein kinase SIK2

1

4

Small-scale

0.479

High

179249

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

179254

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.479

High

179255

NDE1
Nuclear distribution protein nudE homolog 1

1

12

Small-scale

0.479

High

179261

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.479

High

179262

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

179264

TBK1
Serine/threonine-protein kinase TBK1

1

5

High-throughput

0.479

High

179265

PKHG1
Pleckstrin homology domain-containing family G member 1

1

4

High-throughput

0.479

High

179267

MAFF
Transcription factor MafF

1

2

Small-scale

0.479

High

179121

PROF1
Profilin-1

1

0

Small-scale

0.458

High

179128

PPGB
Lysosomal protective protein

1

0

Small-scale

0.458

High

179212

ECM1
Extracellular matrix protein 1

1

0

Small-scale

0.458

High

179247

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

179257

IL36G
Interleukin-36 gamma

1

0

Small-scale

0.458

High

179106

PAK4
Serine/threonine-protein kinase PAK 4

1

6

High-throughput

0.445

High

179127

H14
Histone H1.4

1

8

High-throughput

0.445

High

179151

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.445

High

179171

TERA
Transitional endoplasmic reticulum ATPase

1

10

High-throughput

0.445

High

179201

CTBP1
C-terminal-binding protein 1

1

7

High-throughput

0.445

High

179216

Q5JYA6
PLEKHG1

1

4

High-throughput

0.445

High

179113

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

179138

PO3F2
POU domain, class 3, transcription factor 2

1

5

Small-scale

0.437

High

179152

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

179165

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

11

High-throughput

0.437

High

179196

CGNL1
Cingulin-like protein 1

1

3

Small-scale

0.437

High

179231

CHUR
Protein Churchill

1

1

High-throughput

0.437

High

179239

EFHD2
EF-hand domain-containing protein D2

1

4

Small-scale

0.437

High

179269

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

8

Small-scale

0.437

High

179166

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.408

High

179218

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

179220

CLC4G
C-type lectin domain family 4 member G

1

2

Small-scale

0.407

High

104277

F227A
Protein FAM227A

2

0

High-throughput

0.313

High

179240

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

179243

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

179248

UBTD1
Ubiquitin domain-containing protein 1

1

0

High-throughput

0.269

Low

179221

CA122
Uncharacterized protein C1orf122

1

0

Small-scale

0.249

Low

179256

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025