HitPredict

Interactor 1: RPB4 (O15514)
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)
Gene: POLR2D

Interactor 2: RPB2 (P30876)
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)
Gene: POLR2B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.934

Property	Details
Experiments	28514442, 24981860, 33961781, 35271311, 10567706
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RNA_pol_Rpb2_3~RNA_pol_Rpb4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005665 - RNA polymerase II, core complex GO:0006366 - transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 142 Hs			1 1174
+	Sc
		470456 RPB4_YEAST (42-140): 3.41e-27: 102: 35.58		RPB2_YEAST (4-1173): 0: 1472: 58.05
+	Hs
		192869 RPB4_HUMAN (1-142): 4.02e-59: 181: 100.00		RPC2_HUMAN (18-1172): 0: 1360: 37.14
+	Hs
		192858 RPB4_HUMAN (1-142): 4.02e-59: 181: 100.00		RPA2_HUMAN (36-1174): 0: 1199: 28.34