HitPredict

Interactor 1: RING1 (O35730)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)
Gene: RING1

Interactor 2: CBX2 (P30658)
Chromobox protein homolog 2 (M33) (Modifier 3 protein)
Gene: CBX2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	9312051, 10369680
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0003682 - chromatin binding GO:0006325 - chromatin organization GO:0016607 - nuclear speck GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 519
+	Hs
		987972 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX2_HUMAN (1-519): 2.3e-135: 404: 82.40
+	Mm
		675501 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX2_MOUSE (1-519): 1.66e-149: 439: 100.00
+	Hs
		123243 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX4_HUMAN (3-509): 2.99e-100: 314: 22.20
+	Mm
		223231 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX4_MOUSE (3-509): 1.29e-102: 320: 21.45
+	Hs
		123308 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX4_HUMAN (3-509): 2.99e-100: 314: 22.20
+	Mm
		193417 RING1_MOUSE (1-406): 8.02e-116: 345: 100.00		CBX8_MOUSE (3-321): 2.1e-56: 194: 25.00
+	Hs
		988024 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX8_HUMAN (3-321): 7.26e-49: 174: 22.84
+	Mm
		1321744 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX8_MOUSE (3-321): 2.1e-56: 194: 25.00
+	Hs
		327842 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX7_HUMAN (3-245): 6.88e-41: 149: 28.80
+	Hs
		949760 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX1_HUMAN (18-168): 2.21e-40: 145: 22.52
+	Hs
		987963 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX3_HUMAN (10-168): 5.64e-39: 142: 20.76
+	Mm
		1164651 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		Q6TKP2_MOUSE (3-427): 4.32e-46: 172: 20.41
+	Hs
		316019 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX6_HUMAN (3-357): 2.49e-34: 135: 24.05
+	Mm
		193412 RING1_MOUSE (1-406): 8.02e-116: 345: 100.00		CBX7_MOUSE (3-98): 1.49e-28: 112: 49.49
+	Mm
		1321737 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX6_MOUSE (3-359): 4.84e-40: 151: 24.12
+	Hs
		327858 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX7_HUMAN (3-245): 6.88e-41: 149: 28.80
+	Mm
		1321739 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		Q9DCC5_MOUSE (10-168): 5.64e-39: 142: 20.76
+	Mm
		613033 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX3_MOUSE (10-168): 7.68e-39: 141: 20.13
+	Hs
		316133 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX6_HUMAN (3-357): 2.49e-34: 135: 24.05
+	Mm
		1257537 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX7_MOUSE (3-98): 1.49e-28: 112: 49.49